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TOP  > 教員情報  > 医療科学部  > 臨床検査学科  > 藤垣 英嗣

藤垣 英嗣

職名講師
専攻・専門分野病態生化学
主な担当科目病態生化学、検査機器総論、基礎機器分析実習
所属学会臨床化学会、生化学会、臨床衛生検査技師会


メッセージ

皆さんが充実した大学生活を送れるようサポートしていきたいです。

略歴

1999年岐阜大学医学部附属病院検査部
2006年岐阜大学大学院医学系研究科 博士(医学) 取得
2006年米国国立がん研究所(NCI) Laboratory of Cell Biology
2011年広島国際大学保健医療学部 講師
2017年藤田保健衛生大学医療科学部 講師

研究・業績

研究テーマ


  • トリプトファン代謝酵素の生化学的解析

  • 新規治療薬スクリーニング法の開発

論文


  1. Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K. Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1. Sci Rep. 2016 Jul 20;6:29920.

  2. Fujigaki H, Yamamoto Y, Saito K. L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences. Neuropharmacology. 2017 Jan;112(Pt B):264-274.

  3. Sakai H, Fujigaki H, Mazur SJ, Appella E. Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. Cell Cycle. 2014;13(6):1015-29.

  4. Fujigaki H, Seishima M, Saito K. Posttranslational modification of indoleamine 2,3-dioxygenase. Anal Bioanal Chem. 2012 Jun;403(7):1777-82.

  5. Englund EA, Wang D, Fujigaki H, Sakai H, Micklitsch CM, Ghirlando R, Martin-Manso G, Pendrak ML, Roberts DD, Durell SR, Appella DH. Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds. Nat Commun. 2012 Jan 10;3:614.

  6. Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Banerjee B, Hande MP, Miyamoto T, Miyoshi I, Shirai T, Motoyama N, Delhase M, Appella E, Nakanishi M. Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J. 2010 Oct 20;29(20):3558-70.

  7. Hoshi M, Saito K, Hara A, Taguchi A, Ohtaki H, Tanaka R, Fujigaki H, Osawa Y, Takemura M, Matsunami H, Ito H, Seishima M. The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse. J Immunol. 2010 Sep 15;185(6):3305-12.

  8. Suzuki M, Fujii H, Fujigaki H, Shinoda S, Takahashi K, Saito K, Wada H, Kimoto M, Kondo N, Seishima M. Lipocalin-type prostaglandin D synthase and egg white cystatin react with IgE antibodies from children with egg allergy. Allergol Int. 2010 Jun;59(2):175-83

  9. Hoshi M, Ito H, Fujigaki H, Takemura M, Takahashi T, Tomita E, Ohyama M, Tanaka R, Ohtaki H, Saito K, Seishima M. Changes in serum tryptophan catabolism as an indicator of disease activity in adult T-cell leukemia/lymphoma. Leuk Lymphoma. 2009 Aug;50(8):1372-4.

  10. Hoshi M, Saito K, Murakami Y, Taguchi A, Fujigaki H, Tanaka R, Takemura M, Ito H, Hara A, Seishima M. Marked increases in hippocampal neuron indoleamine 2,3-dioxygenase via IFN-gamma-independent pathway following transient global ischemia in mouse. Neurosci Res. 2009 Mar;63(3):194-8.

  11. Hoshi M, Ito H, Fujigaki H, Takemura M, Takahashi T, Tomita E, Ohyama M, Tanaka R, Saito K, Seishima M. Indoleamine 2,3-dioxygenase is highly expressed in human adult T-cell leukemia/lymphoma and chemotherapy changes tryptophan catabolism in serum and reduced activity. Leuk Res. 2009 Jan;33(1):39-45.

  12. Fujigaki H, Saito K, Fujigaki S, Takemura M, Sudo K, Ishiguro H, Seishima M. The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways, and synergistic effect of several proinflammatory cytokines. J Biochem. 2006 Apr;139(4):655-62.

  13. Fujigaki H, Saito K, Lin F, Fujigaki S, Takahashi K, Martin BM, Chen CY, Masuda J, Kowalak J, Takikawa O, Seishima M, Markey SP. Nitration and inactivation of IDO by peroxynitrite. J Immunol. 2006 Jan 1;176(1):372-9.

  14. Takemura M, Fujigaki H, Takahashi K, Saito K, Fujii H, Wada H, Seishima M. Genotyping and the quantification of hepatitis C virus by the melting curves in light cycler. Rinsho Byori. 2004 Feb;52(2):167-71. Review.

  15. Fujigaki H, Takemura M, Takahashi K, Yamada Y, Fujii H, Wada H, Saito K, Ohnishi H, Seishima M. Genotyping of hepatitis C virus by melting curve analysis with SYBR Green I. Ann Clin Biochem. 2004 Mar;41(Pt 2):130-2.