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TOP  > 教員情報  > 医療科学部  > 臨床検査学科  > 若松 一雅

若松 一雅

職名特任教授
専攻・専門分野化学
主な担当科目化学、基礎科学(化学)実験、自然科学情報論
所属学会日本色素細胞学会、日本癌学会
日本皮膚悪性腫瘍学会


メッセージ

誰でも人は、マイナスなこともプラスなことも吐く。だから、吐くという字は、口と+と-で出来ている。マイナスなことを言わなくなると-が消えて叶という字になる。人生、ポジティブ思考で行きましょう。

略歴

1977年名古屋大学理学部 卒業
1979年名古屋大学大学院理学研究科前期課程 修了
1979年愛知医科大学化学教室 助手
1981年名古屋大学大学院理学研究科大学院 研究生
1986年理学博士(名古屋大学)
1987年藤田学園保健衛生大学衛生学部 助手
1988年藤田学園保健衛生大学衛生学部 講師
1995年博士(医学)(藤田保健衛生大学)
1995年英国ニューキャッスルアポンタイン大学医学部皮膚科 留学
1996年藤田保健衛生大学衛生学部 助教授
2001年スウェーデン国リンショーピン大学臨床化学Visiting Professor
2001年藤田保健衛生大学大学院保健学研究科臨床分析化学分野(修士課程)専任助教授
2003年藤田保健衛生大学衛生学部微量成分分析学 教授
藤田保健衛生大学大学院保健学研究科臨床分析化学分野(修士課程)専任教授
2008年藤田保健衛生大学医療科学部化学 教授

研究・業績

研究テーマ

当研究室では、メラニン色素の微量分析法を開発し、その方法を用いて生体のメラニン色素の化学的・生化学的役割を研究しています。メラニン色素を分析できる技術を持った施設は、国内外でもほとんどないため、国内・海外からメラニンの分析依頼検体がたくさん送られてきます。 

論文

  1. Wakamatsu, K., Ito, S., and Rees, J. L. Usefulness of 4-amino-3-hydroxyphenylalanine as a specific marker of pheomelanin. Pigment Cell Res., 15, 225-232, 2002.
  2. D’Orazio, J. A., Nobuhisa, T., Cui, R., Arya, M., Spry, M., Wakamatsu, K., Igras, V., Kunisada, T., Granter, S. R., Nishimura, E. K., Ito, S., Fisher, D. E. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature, 443, 340-344, 2006.
  3. Wakamatsu, K., Ohtara, K., Ito, S. Chemical analysis of late stages of pheomelanogenesis: conversion of dihydrobenzothiazine to a benzothiazole structure. Pigment Cell & Melanoma Res., 22, 474-486, 2009.
  4. Ito, S., Nakanishi, Y., Valenzuela, R.K., Brilliant, M.H., Kolbe, L., Wakamatsu, K. Usefulness of alkaline hydrogen peroxide oxidation to analyze eumelanin and pheomelanin in various tissue samples: application to chemical analysis of human hair melanins. Pigment Cell Melanoma Res.24, 605-613, 2011.
  5. Ito, S., Wakamatsu, K., M. d’Ischia, A. Napolitano, A. Pezzella. Structure of Melanins: Melanins and Melanosomes. J. Borovansk?, P. A. Riley (eds), Wiley-Blackwell, 167-185, 2011.
  6. Ito, S., Wakamatsu, K. Diversity of human hair pigmentation as studied by chemical analysis of eumelanin and pheomelanin. J. Eur. Acad. Dermatol. Venereol., 25, 1369-1380, 2011.
  7. Wakamatsu, K., Nakanishi, Y., Miyazaki, N., Kolbe, L., Ito, S. UVA-induced oxidation degradation of melanins: Fission of indole moiety in eumelanin and conversion to benzothiazole moiety in pheomelanin. Pigment Cell Melanoma Res., 25, 434-445, 2012.
  8. Glass, K., Ito, S., Wilby, P.R., Sota, T., Nakamura, A., Bowers, C.R., Vinther, J., Dutta, S., Summons, R., Briggs, D.E., Wakamatsu, K., Simon, J.D. Direct chemical evidence for eumelanin pigment from the Jurassic period. Proc. Natl. Acad. Sci. USA, 109, 10218-10223, 2012.
  9. Wakamatsu, K., Murase, T., Zucca, F.A., Zecca, L., Ito, S. Biosynthetic pathway to neuromelanin and its aging process. Pigment Cell Melanoma Res., 25, 792-803, 2012.
  10. Ito, S., Wakamatsu, K., Glass, K., Simon, J. D. HPLC estimation of cross-linking of dihydroxyindole moiety in eumelanin. Anal. Biochem. 434, 221-225, 2013.
  11. Engelen, M., Vanna, R., Bellei, C., Zucca, F. A., Wakamatsu, K., Monzani, E., Ito. S., Casella, L., Zecca, L. Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure. PLoS One, 7(11); e48490. Doi:10.1371/journal.pone.0048490.
  12. Ito, S., Pilat, A., Gerwat W., Skumatz, C.M.B., Ito, M., Kiyono,A., Zadlo, A., Nakanishi, Y., Kolbe, L., Burke, J.M., Sarna, T.,Wakamatsu, K. Photoaging of human retinal pigment epithelium is accompanied by oxidative modification of its eumelanin. Pigment Cell Melanoma Res., 26, 357-366, 2013.
  13. Jimbow, K., Ishii-Osai, Y., Ito, S., Tamura, Y., Ito, A., Yoneta, A., Kamiya, T., Yamashita, T., Honda, H., Wakamatsu, K., Murase, K., Nohara, S., Nakayama, E., Hasegawa, T., Yamamoto, I., Kobayashi, T. Melanoma-targeted chemothermotherapy and in situ peptide immunotherapy through HSP production by using melanogenesis substrate, NPrCAP, and magnetite nanoparticles. J. Skin Cancer, doi: 10.1155/2013/742925.
  14. Nicola, S., Romano, M., Rubolini, D., Ambrosini, R., Caprioli, M., Milzani, A., Costanzo, A., Canova, L., Wakamatsu, K. Viabilitu is associated with melanin-based colouration in the barn swallow (Hirundo rustica). Plos One. 8, e58024, 2013.
  15. Galván, I., Jorge, A., Solano, F., Wakamatsu, K. Vibrational characterization of pheomelanin and trichochrome F by Raman spectroscopy. Spectrochimica Acta Part A Molecular and Biomolecular Spctroscopy, 110, 55-59, 2013.
  16. Hirobe, T., Ito, S., Wakamatsu, K. The mouse ruby-eye 2d (ru2d/Hps5ru2-d) allele inhibits eumelanin but not pheomelanin synthesis. Pigment Cell Melanoma Res., 26, 723-726, 2013.
  17. d’Ischia, M., Wakamatsu, K., Napolitano, A., Briganti, S., Garcia-Borron, J-C., Kovacs, D., Meredith, P., Pezzella, A., Picardo, M., Sarna, T., Simon, J.D., Ito, S. Melanins and melanogenesis: methods, standards, protocols. Pigment Cell Melanoma Res., 26, 616-633, 2013.
  18. Roulin, A., Mangels, J., Wakamatsu, K., Bachmann, T. Sexually dimorphic melanin-based colour polymorphism, feather melanin content, and wing feather in the barn owl ‘Tyto alba’. Biol. J. the Linnean Soc., 109, 562-573, 2013.
  19. Singaravelan, N., Ratz, S., Tzur, S., Belifante, S., Pavlicek, T., Beiles, A., Ito, S., Wakamatsu, K., Nevo, E. Adaptation of pelage color and pigment variations in Israel subterranean blind mole rats, Splax ehrenbergi. Plos One. 8, e69346, 2013. doi:10.1371/journal.pone.0069346.
  20. Galván, I., Jorge, A., Ito, K., Tabuchi, K., Solano, F., Wakamatsu, K. Raman Spectroscopy as a non-invasive technique for the quantification of melanins in feathers and hairs. Pigment Cell melanoma Res., 26, 917-923, 2013.
  21. Ito, S., Suzuki, N., Takebayashi, S., Commo, S., Wakamatsu, K. Neutral pH and copper ions promote eumelanogenesis after the dopachrome stage. Pigment Cell Melanoma Res. 26, 817-825, 2013.
  22. Roulin, A., Mafli, A., Wakamatsu, K. Reptiles produce pheomelanin: Evidence in the Eastern Hermann’s Tortoise (Eurotestudo boettgeri). J. Herpetol. 47, 258-261, 2013.
  23. Cransberg R., Wakamatsu K., Munyard K. Melanin characterization suggests that the ‘brown’ phenotype in alpaca (Vicugna pacos) is predominantly pheomelanic. Small Ruminant Res. 114, 240-246, 2013.
  24. Glass, K., Ito, S., Wilby, P. R., Sota, T., Nakamura, A., Bowers, C. R., Miller, K. E., Dutta, S., Summons, R. E., Briggs, D. E.G., Wakamatsu, K., Simon, J. D. Impact of diagenesis and mutation on the survival of eumelanin in the fossil record. Organic Geochem., 64, 29-37, 2013.
  25. Mizote, Y., Wakamatsu, K., Ito, S., Uenaka, A., Ohue, Y., Kurose, K., Isobe, M., Ito, A., Tamura, Y., Honda, H., Yamashita, T., Nohara, S., Oka, M., Jimbow, K., Nakayama, E. TLR4 and NLRP3 inflammasome activation in monocytes by N-propionyl cysteaminylphenol-maleimide-dextran (NPCMD). J. Dermatol. Sci., 73, 209-215, 2014.
  26. Fargallo, J.A., Velando, A., L., Lopez-Rull, I., Ganan, N., Lifshiz, N., Wakamatsu, K., Torres, R. Sex-specific phenotype integration: endocrine profiles, coloration and behavior in fledgling boobies. Behavioral Ecology, 25, 76-87, 2014.
  27. Calhim, S., Adamík, P., Järvistö, P., Leskinen, P., Török, J., Wakamatsu, K., Laaksonen, T. Heterospecific female mimicry in ficedula flycatchers. J. Evol. Biol., 27, 660-666, 2014.
  28. Hirobe, T., Ito, S., Wakamatsu, K., Kawa, Y., Abe, H. The mouse brown (b/Tyrp1b) allele does not affect pheomelanin synthesis in mice. Zool. Sci., 31, 53-63, 2014.
  29. Yoshizawa, J., Abe, Y., Oiso, N., Fukai, K., Hozomi, Y., Nakamura, T., Narita, T., Motokawa, T., Wakamatsu, K., Ito, S., Kawada, A., Tamiya, G., Suzuki, T. Variants in melanogenesis-related genes associated with cancer risk among Japanese populations. J. Dermatol., 41, 296-302, 2014.
  30. Galván, I., Bonisoli-Alquati, A., Jenkinson, S., Ghanem, G., Wakamatsu, K., Mousseau, T.A., Møller, A.P. Chronic exposure to low-dose radiation at Chernobyl favors adaptation to oxidative stress in birds. Functional Ecology, DOI: 10.1111/1365-2435.12283.
  31. Galván, I., Wakamatsu, K., Alonso-Alvarez, C., Solano, F. Buthionine sulfoximine diverts the melanogenesis pathway toward the production of more soluble and degradable pigments. Bioorg. Med. Chem. Lett. 24, 2150-2154, 2014.
  32. Okuda, H., Yoshino, K., Wakamatsu, K., Ito, S., Sota, T. Degree of polymerization of 5,6-dihydroxyindole-derived eumelanin from chemical degradation study. Pigment Cell Melanoma Res., 27. 664-667, 2014.
  33. Ito, S., Ojika, M., Yamashita, T., Wakamatsu, K. Tyrosinase-catalyzed oxidation of Rhododendrol produces 2-methylchromane-6,7-dione, the putative ultimate toxic metabolite: implication for melanocyte toxicity. Pigment Cell Melanoma Res. DOI: 10.1111/pcmr.12275.
  34. Wakamatsu, K., Tanaka, H., Tabuchi, K., Ojika, M.,Zucca, F.A., Zecca, L., Ito, S. Reduction of the nitro group to amine by hydroidoic acid to synthesize o-aminophenol derivatives as putativedegradative markers of neuromelanin. Molecules, 19(6), 8039-8050, 2014, doi:10.3390/molecules19068039.

その他

  • 日本色素細胞学会事務局長
  • 日本色素細胞学会理事