過去20年間の研究業績-1/3(1983-2003年)


原著論文
. Phenobabital and 3-methylcholanthrene-induced syntheses of two different molecular species of microsomal cytochrome P-450 in rat liver. (Harada, N. & Omura, T.)J. Biochem.; 93, 1361-1373, 1983

. Purification and characterization of four forms of cytochrome P-450 from liver microsomes of phenobarbital-treated and 3-methylcholanthrene-treated rats. (Kuwahara, S., Harada, N., Yoshioka, H., Miyata, T., & Omura, T.) J. Biochem.; 95, 703-714, 1984

. Rate-limiting steps in cytochrome P-450-catalyzed reactions. Studies on isotope effects in the 0-deethylation of 7-ethoxycoumarin. (Lu, A.Y.H., Harada, N., & Miwa, G.T.) Xenobiotica; 14, 19-26, 1984

. Kinetic isotope effexcts in cytochrome P-450-catalyzed oxidation reactions. Evidence for the irreversib le formation of an activated oxygen intermediate of cytochrome P-448. (Harada, N., Miwa, G.T., Walsh, J.S., & Lu, A.Y.H.) J. Biol. Chem.; 259(5), 3005-3010, 1984

5. Mouse liver testosterone 15a-hydroxylase (cytochrome P-450 15a). Purification, regioselectivity, stereospecificity, and sex-dependent expression. (Harada, N. & Negishi, M.) J. Biol. Chem.; 259(2), 1265-1271, 1984

6. Mouse liver testosterone 16a-hydroxylase (cytochrome P-450 16a). Purification, regioselectivity, stereospecificity, and immunochemical characterization. (Harada, N. & Negishi, M.) J. Biol. Chem.; 259 (19), 12285-12290, 1984

7. Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. Full expression of the intrinsic isotope effect during the 0-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene induced hamsters. (Miwa, G.T., Harada, N., & Lu, A.Y.H.) Arch. Biochem. Biophys.; 239 (1), 155-162, 1985

8. Sex-dependent expression of mouse testosterone 16a-hydroxylase (P-450 16a): cDNA cloning and pretranslational regulationl. (Harada, N. & Negishi, M.) Proc. Natl. Acad. Sci. U.S.A.; 82(4), 2024-2028, 1985

9. Characterization of testosterone 16a-hydroxylase (1-P-450 16a) induced by phenobarbital in mice. (Devore, K., Harada, N., & Negishi, M.) Biochemistry 24(20), 5632-5637, 1985

10. Sexual dimorphism of testosterone 15a-hydroxylase mRNA levels in mouse liver. c-DNA cloning and regulation. (Burkhart, B.A., Harada, N., & Negishi, M.) J. Biol. Chem.; 260(28), 15357-15361, 1985

11. Identification of a polymyxin produced by a synbiotic microorganism isolated from the brown planthopper, Nilaparavata lugens. (Jigami, Y., Harada, N., Umemura, H., Tanaka, H., Ishikawa, K., Nakasato, S., Kita, H., & Sugiura, M.) Agr. Biol. Chem.; 50, 1637-1639, 1986

12. Expression of synthetic human lyxozyme gene in Escherichia coli. (Muraki, M., Jigami, Y., Tanaka, H., Harada, N., Kishimoto, F., Agui, H., Ogino, S., & Nakasato, S.) Agr. Biol. Chem.; 50, 713-723, 1986

13. Expression of synthetic human-lysozyme gene in Saccharomyces cereviciae : Use of a synthetic chicken-lysoztyme signal sequence for secretion and processing. (Jigami, Y., Muraki, M., Harada, N., & Tanaka, H.) Gene ; 43, 273-279, 1986

14. Depression in gene expression for poly-ADP-ribose) synthetase during the interferon-g-induced acticvation process of murine macrophage tumer cells(Taniguchi, T., Yamauchi, K., Yamamoto, Y., Toyoshima, K., Harada, N., Tanaka, H., Takahashi, H., Yamamoto, H., & Fujimoto, S.) Eur. J. Biochem.; 171, 571-575, 1986

15. Substrate specificities of cytochrome P-450, C-P-450 16a and P-450 15a, and contribution to steroid hydroxylase activites in mouse liver microsomes. (Harada, N. & Negishi, M.)Biochem. Pharmacol.; 37, 4778-4780, 1988

16. Novel properties of human placental aromatase as cytochrome P-450: Purification and characterization of a unique from of aromatase. (Harada, N.) J. Biochem.; 103, 106-113, 1988

17. Cloning of a complete cDNA encoding human aromatase: Immunochemical identification and sequence analysis. (Harada, N.)Biochem. Biophys. Res. Commun.; 156, 725-732, 1988

18. Distribution of aromatase in the brain of the Japanese quail, ring dove and zebra finch: and immunocytochemical study. (Balthazart, J., Foidart, A., Surlemont, C., Vockel, A., & Harada, N.) J. Comp. Neuol.; 301, 276-288, 1990

19. Expression of estrogen synthetase (P-450 aromatase) during adipose differentiation of 3T3-L1 cells. (Yamada, K. & Harada, N.) Biochem. Biophys. Res. Commun. 169(2), 531-536, 1990

20. Immunocytochemical localization of aromatase in the brain. (Balthazart, J., Foidart, A., & Harada, N.) Brain Res.; 514, 327-333, 1990

21. Structural characterization of the human estrogen synthetase (aromatase) gene. (Harada, N., Yamada, K., Saito, K., Kibe, N., Dohmae, S., & Takagi, Y.) Biochem. Biophys. Res. Commun.; 166(1), 365-372, 1990

22. Immunoelectron microscopic localization of aromatase in human placenta and ovary using microwave fixation. (Naganuma, M., Ohtasni, H., Harada, N., & Nagura, H.) J. Histochem. Cytochem.; 38(10), 1427-1432, 1990

23. Distribution of aromatase-immunoreactive cells in the mouse forebrain(Balthazart, J., Foidart, A., Surlemont, C., & Harada, N.) Cell Tissue Res.; 263, 71-79, 1991

24. Neuroanatomical specificity in the co- localization of aromatase and estrogen receptors. (Balthazart, J., Foidart, A., Surlemont, C., & Harada, N.) J. Neurobiol.; 22(2), 143-157, 1991

25. Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency. (Harada, N., Ogawa, H., Shozu, M., Yamada, K., Suhara, K., Nishida, E., & Takagi, Y.) J. Biol. Chem.; 267(7), 4781-4785, 1992

26. Aromatase as a cellular marker of testosterone action in the preoptic area. (Balthazart, J., Surlemont, C., & Harada, N.) Physiol. Behav.; 51, 395-409, 1992

27. Expression and transport into mitochondoria of bovine cytochrome P-450(SCC) in insect cells using the baculovirus expression system. (Takagi, Y., Ogawa, H., Harada, N., Shimada, H., Ishimura, Y., & Takagi, Y.) Biochem. Biophys. Res. Commun.; 184(1), 471-477, 1992

28. Neuroanatomical specificity in the autoregulation of aromatase- immunoreactive neurons by androgens and estrogens: an immunocytochemical study. (Balthazart, J., Foidart, A., Surlemont, C., Harada, N., & Naftolin, F.) Brain Res.; 574, 280-290, 1992

29. Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone. (Harada, N., Yamada, K., Foidart, A., & Balthazart, J.) Mol. Brain Res.; 15, 19-26, 1992

30. Genetic studies to characterize the origin of the mutation in placental aromatase deficiency. (Harada, N., Ogawa, H., Shozu, M., & Yamada, K.) Am. J. Hum. Genet.; 51, 666-672, 1992

31. Ontogeny of aromatase messenger ribonucleic acid in mouse brain: fluorometrical quantitation by polymerase chain reaction. (Harada, N. & Yamada, K.) Endocrinology; 131(5), 2306-2312, 1992

32. A unique aromatase (P-450AROM) mRNA formed by alternative use of tissue-specific exons 1 in human skin fibroblasts. (Harada, N.) Biochem. Biophys. Res. Commun.; 189(2), 1001-1007, 1992

33. bcl-2 gene is highly expressed during neurogenesis in the central nervous system. (Abe-Dohmae, S., Harada, N., Yamada, K., & Tanaka, R.) Biochem. Biophys. Res. Commun.; 191(3), 915-921, 1993

34. Genetic analysis of human placental aromatase deficiency. (Harada, N.) J. Steroid Biochem. Molec. Biol.; 44 (4-6), 331-340, 1993

35. Aromatase immunoreactivity in the rat brain: gonadectomy-sensitive hypothalamic neurons and an unresponsive "limbic ring" of the lateral septum-bed nucleus-amygdala complex. (Jakab, R.L., Horvath, T.L., Leranth, C., Harada, N., & Naftolin, F.) J. Steroid Biochem. Molec. Biol.; 44 (4-6), 481-498, 1993

36. Core-glycosylation of cytochrome P-450(arom); evidence for localization of N-terminus of microsomal cytochrome P-450 in the lumen. (Shimozawa, O., Sakaguchi, M., Ogawa, H., Harada, N., Mihara, K., & Omura, T.) J. Biol. Chem.; 268 (28), 21399-21402, 1993

37. Synergism between androgen and estrogens in the induction of aromatase and its messenger RNA in the brain. (Harada, N., Dohmae, S., Loeffen, R., Foidart, A., & Balthazart, J.) Brain Res.; 622, 243-256, 1993

38. Molecular cloning of a cDNA encoding human histidase. (Suchi, M., Harada, N., Wada, Y., & Takagi, Y.) Biochim. Biophys. Acta ; 1216, 293-295, 1993

39. Effects of changes in gonadal hormones on the amounts of aromatase messenger RNA in mouse brain diencephalon. (Yamada, K., Harada, N., Tamaru, M., & Takagi, Y.) Biochem. Biophys. Res. Commun.; 195 (1), 462-468, 1993

40. Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. (Harada, N., Utsumi, T., & Takagi, Y.) Proc. Natl. Acad. Sci. USA.; 90 (23), 11312-11316, 1993

41. Aromatase-immunoreactive cells in the quail brain: Effects of testosterone
and sex dimorphism. (Foidart, A., Clerk A.D., Harada, N., & Balthazarty, J.) Physiol. Behav.; 55 (3), 453-464, 1994

42. Distribution and steroid dependence of aromatase enzyme immunoreactivity in limbic nuclei of the female musk shrew brain. (Dellovade, T.L., Harada, N., & Rissman, E.F.) Brain Res.; 634, 141-149, 1994

43. Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain. (Honda, S., Harada, N., & Takagi, Y.) Biochem. Biophys. Res. Commun.; 198 (3), 1153-1160, 1994

44. Cell type- and region-specific expression of aromatase mRNA in cultured brain cells. (Abe-Dohmae, S., Tanaka, R., & Harada, N.) Mol. Brain Res.; 24,153-158, 1994

45. Immunolocalization of aromatase and other steroidgenic enzymes in human breast disorders. (Sasano, H., Nagura, H., Harada, N., Goukon Y., & Kimura, M.) Human Pathol.; 25, 530-535, 1994

46. Stromal spindle cells contain aromatase in human breast tumors. (Santen, R.J., Martel, J., Hoagland, M., Naftolin, F., Roa, L., Harada, N., Hafer, L., Zaino, R., & Santner, S.J.) J. Clin. Endocrinol. Metab.; 79, 627-632, 1994

47. Synergistic control by androgens and estrogens of aromatase in the quail brain. (Balthazart, J., Stoop, R., Foidart, A., & Harada, N.) NeuroReport; 5, 1729-1732, 1994

48. Baculovirus mediated high level expression of human placental aromatase.(CYP19A1). (Sigle, R.O., Titus, M.A., Harada, N., & Nelson, S.D.) Biochem. Biophys. Res. Commun.; 201, 694-700, 1994

49. Effects of steroidal and non steroidal aromatase inhibitors on sexual behavior and aromatase-immunoreactive cells and fibers in the quail brain. (Foidart, A., Harada, N., & Balthazart, J.) Brain Res.; 657, 105-123, 1994

50. Morphometric studies demonstrate that aromatase-immunoreactive cells are the main target of androgens and estrogens in the quail medial preoptic nucleus. (Aste, N., Panzica, G.C., Aimar, P., Viglietti-Panzica, C., Harada, N., Foidart, A., & Balthazart, J.) Exp. Brain Res.; 101, 241-252, 1994

51. Aromatase- (estrogen synthetase) immunoreactive neurons in the rat septal area. A light and electron microscopic study. (Jakab, R.L., Harada, N., & Naftolin, F.) Brain Res.; 664, 85-93, 1994

52. Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies. (Watanabe, K., Sasano, H., Harada, N., Ozaki, M., Niikura, H., Sato, S., & Yajima, A.) Am. J. Pathol.; 146, 491-500, 1995

53. Purification and characterization of a new isoform of cytochrome P-450 responsible for 3-hydroxylation of 2, 5, 2', 5'-tetrachlorobiphenyl in hamster liver. (Koga, N., Nishimura-Kikuchi, N., Hara, T., Harada, N., Ishii, Y., Yamada, H., Oguri, K, & Yoshimura, H.) Arch. Biochem. Biophys.; 317, 464-470, 1995

54. Co-localization of aromatase enzyme and estrogen receptor immunoreactivity in the preoptic area during reproductive aging. (Dellovade, T.L., Rissman,E.F., Thompson, N., Harada, N., & Ottinger, M.A.) Brain Res.; 674, 181-187,1995

55. Molecular and epidemiological analyses of abnormal expression of aromatase in breast cancer. (Harada, N., Utsumi, T., & Takagi, Y.) Pharmacogenetics; 5, 59-64, 1995

56. Regulation of placenta-specific expresssion of the aromatase cytochrome P-450 gene; Involvement of the trophoblast specific element binding protein. (Yamada, K., Harada, N., Honda, S., & Takagi, Y.) J. Biol. Chem.; 270, 25064-25069, 1995

57. Aromatase-immunoreactive cells are present in mouse brain areas that are known to express high levels of aromatase activity. (Foidart, A., Harada, N., &Balthazart, J.) Cell Tissue Res.; 280, 561-574, 1995

58.  Critical re-examination of the distribution of aromatase-immunoreactive cells
in the quail forebrain using antibodies raised against human placental aromatase and against the recombinant quail, mouse, and human enzyme. (Foidart, A., Reid, J., Absil, P., Yoshimura, N., Harada, N., & Balthazart, J.) J. Chemical Neuroanatomy; 8, 267-282, 1995

59. Pre- and post-translational regulation of aromatase by steroidal and non- steroidal aromatase inhibitors. (Foidart, A., Telmcani, O., Harada, N., Abe- Dohmae, S., & Balthazart, J.) Brain Res.; 701, 267-278, 1995

60. Functional aromatase expression in porcine adrenal gland and testis. (Conley, A.J., Corbin, C.J., Hinshelwood, M.M., Liu, Z., Simpson, E.R., Ford, J.J., & Harada, N.) Biol. Reprod.; 54, 497-505, 1996

61.  In vitro increase of aromatase mRNA in diencephalic neurons. (Abe-Dohmae, Tanaka, R., Takagi, Y., & Harada, N.) Neuroendocrinology; 63, 46-52, 1996

62. The alternative exons 1 of the mouse aromatase cytochrome P-450 gene.(Honda, S., Harada, N., & Takagi, Y.) Biochim. Biophys. Acta ; 1305, 145-150, 1996

63. Effects of testosterone and its metabolites on aromatase-immunoreactive cells in the quail brain: Relationship with the activation of male reproductive behavior. (Balthazart, J., Foidart, A., Absil, P., & Harada, N.) J. Steroid Biochem. Molec. Biol.; 56, 185-200, 1996

64. Aromatase immunoreactivity in axon terminals of the vertebrate brain: An electron microscopic immunocytochemical study on quail, rat, monkey, and human tissues. (Naftolin, F., Horvath, T.L., Jakab, R.L., Leranth, C., Harada, N., & Balthazart, J.) Neuroendocrinology; 63, 149-155, 1996

65. Presence of alternatively spliced transcripts of aromatase gene in human breast cancer. (Utsumi, T., Harada, N., Maruta, M., & Takagi, Y.) J. Clin. Endocrinol. Metab; 81, 2344-2349, 1996

66. Aromatase cytochrome P450 gene expression in endometrial carcinoma: An anlysis of alternative splicing of exons 1 in seven cases. (Sasano, H., Kaga, K., Sato, S., Yajima, A., Nagura, H., & Harada, N.) Br. J. Cancer ; 74, 1541-1544, 1996

67. Effect of vorozole, an aromatase enzyme inhibitor, on sexual behavior, aromatase activity and neural immunoreactivity. (Rissman, E.F., Harada, N., & Roselli, C.E.) J. Neuroendocrinol. ; 8, 199-210, 1996

68. Intraovarian immunolocalization of steroidgenic enzymes in a Hokkaido brown bear, Ursus arctos yesoensis during the mating season. (Araki, H., Tsubota, T., Maeda, N., Harada, N., Kominami, S., Mason, J.I., and Kita, I.) J. Vet. Med. Sci.; 58 (8), 787-790, 1996

69. Aromatase in human common epithelial ovarian neoplasms. (Kaga, K., Sasano, H., Harada, N., Ozaki, M., Sato, S., & Yajima, A.) Am. J. Pathol.; 149, 45-51,1996

70. Incomplete testicular feminization syndrome: studies on androgen receptor (AR) function, AR geneanalysis, and aromatase activities at puberty and long-term observations of clinical and hormonal features from infancy to puberty (Isurugi, K., Hasegawa, F., Shibahara, N., Mori, H., Shima, H., Harada, N., Hasegawa, T., Honma, S., Imasaki, K., & Nawata, H.) Endocrine J.; 43, 557-564, 1996

71. Neurotransmitter-mediated regulation of brain aromatase: protein kinase C- and G-dependent induction. (Abe-Dohmae, S., Takagi, Y., & Harada, N.) J. Neurochem.; 67, 2087-2095, 1996

72. Distribution of Aromatase-immunoreactive cells in the forebrain of zebra finches (Taeniopygia guttata): Implication for the neural action of steroids and nuclear definition in the avian hypothalamus. (Balthazart, J., Absil, P., Houbart, M., Harada, N., Ball, G.F.) J. Neurobiol.; 31, 129-148, 1996

73. Localization of testosterone-sensitive and sexually dimorphic aromatase-immunoreactive cells in the quail preoptic area. (Balthazart, J., Tlemcani, O., & Harada, N.) J. Chem. Neuroanatomy; 11, 147-171, 1996

74. Aromatase and 17beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma. (Sasano, H., Frost, A.R., Saito R., Harada, N. , Poutanen, M., Vihko, R., Bulun, S.E., Silverberg, S.G., Nagura, H.) J. Clin. Endocrinol. Metab.; 81, 4042-4046, 1996

75. Aromatase mRNA levels in benign prostatic hyperplasia and prostate cancer. (Tsugaya, M., Harada, N., Tozawa, K., Yamada, Y., Hayashi, Y., Tanaka, S., Maruyama, K., & Kohri, K.) Int. J. Urol.; 3, 292-296, 1996

76. Aromatase deficiency in a girl compound heterozygote for two new point mutations in the P450arom gene: impact of estroges on hypergonadotropic hypogonadism, multicystic ovaries, body composition and bone densitometry in childhood. (Mullis, P.E., Yoshimura, N., Kuhlmann, B., Lippuner, K., Jaeger, P., & Harada, N.) J. Clin. Endocrinol. Metab.; 82, 1739-1745, 1997

77.  Autonomous expression of aromatase during development of mouse brain is modulated by neurotransmitters. (Abe-Dohmae, S., Harada, N., & Takagi, Y.) J. Steroid Biochem. Mol. Biol.; 61, 299-306, 1997

78. Aberrant expression of aromatase in breast cancer tissues. (Harada, N.) J. Steroid Biochem. Mol. Biol.; 61, 175-184, 1997

79. Aromatase in hyperplasia and carcinoma of the human prostate. (Hiramatsu, M., Maehara, I., Ozaki, M., Harada, N., Orikasa, S., & Sasano, H.) The Prostate; 31, 118-124, 1997

80. Aromatase in human bone tissue. (Sasano, H., Uzuki, M., Sawai, T., Nagura, H., Matsunaga, G., Kashimoto, O., & Harada, N. ) J. Bone Miner. Res.; 12, 1416-1423, 1997

81. Arginine-cysteine polymorphism at codon 264 of the human CYP19 gene does not affect aromatase activity. (Watanabe, J., Harada, N., Suemasu, K., Higashi, Y., Gotoh, O., & Kawajiri, K.) Pharmacogenetics; 7, 419-424, 1997

82.  Inhibitors of aromatase prevent degaradation of the enzyme in cultured human tumour cells. (Harada, N. & Hatano, O.) Br. J. Cancer; 77, 567-572, 1998

83. Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver. (Harada, N., Ota, H., Yoshimura, N., Katsuyama, T., & Takagi, Y.) J. Clin. Endocrinol. Metab.; 83, 697-702, 1998

84. Aromatase in human central nervous system. (Sasano, H., Takahashi, K., Sato, F., Nagura, H., & Harada, N.) Clin. Endocrinol.; 48, 325-329, 1998

85. Anatomical relationships between aromatase and tyrosine hydroxylase in the quail brain: Double-label immunocytochemical studies. ( Balthazart, J., Foidart, A., Baillien, M., Harada, N., & Ball, G.F.) J. Comp. Neurol.; 391, 214-226, 1998

86. Distribution and effects of testosterone on aromatase mRNA in the quail forebrain: a non-radioactive in situ hybridization study. (Aste, N., Panzica, G.C., Viglietti-Panzica, C., Harada, N., & Balthazart, J.) J. Chem. Neuroanat.; 14, 103-115, 1998

87. From endocrinology to incrinology. (Sasano, H. Suzuki, T., & Harada N. ) Endocrine Pathology ; 9, 9-20, 1998

88. Intratumoral aromatase in human breast, endometrial and ovarian malignancies. (Sasano, H & Harada, N.) Endocrine Reviews; 19, 593-607, 1998

89. Neuroanatomical distribution and variations across the reproductive cycle of aromatase activity and aromatase-immunoreactive cells in the pied flycatcher (Ficedula hypoleuca). (Foidart, A., Silverin, B., Baillien, M., Harada, N., & Balthazart, J.) Horm. Behav.; 33, 180-196, 1998

90. Adrenocortical and gonadal expression of the mammalian Fts-F1 gene encoding Ad4BP/SF-1 is independent of pituitary control. (Nomura, M., Kawabe, K., Matsushita, S., Oka, S., Hatano, O., Harada, N., Nawata, H., & Morohashi, K.) J. Biochem.; 124, 217-224, 1998

91. Molecular analysis of aberrant expression of aromatase in breast cancer tissue. (Harada, N., & Honda, S.) Breast Cancer Res. Treat.; 49, 15-21, 1998

92. Demonstration of aromatase activity and its regulation in breast tumor and benign breast fibroblasts. (Santen, R.J., Martel, J., Hoagland, M., Naftolin, F., Roa, L., Harada, N., Hafer, L., Zaino, R., Pauley, R., & Santner, S.) Breast Cancer Res. Treat.; 49, 93-99, 1998

93. Macrophages, estrogen and the microemvironment of breast cancer. (Mor, G., Yue, W., Santen, R.J., Gutierrez, L., Eliza, M., Berstein, L.M., Harada, N., Wang, J., Lysiak, J., Diano, S., & Naftolin, F.) J. Steroid Biochem. Mol. Biol.; 67, 403-411, 1998

94. Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. (Honda, S., Harada, N., Ito, S., Takagi, Y., & Maeda, S.) Biochem. Biophys. Res. Commun.; 252, 445-449, 1998

95. Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. (Diano, S., Horvath, T.L., Register, T., Adams, M., Harada, N., & Naftolin, F.) Menopause; 6, 21-28, 1999

96. Steroid sulfatase expression is an independent predictor of reccurrence in human breast cancer. (Utsumi, T., Yoshimura, N., Takeuchi, S., Ando, J., Maruta, M., Maeda, K., & Harada, N.) Cancer Res.; 59, 377-381, 1999

97. Aromatase inhibitors and enzyme stability. (Harada, N., Honda, S., & Hatano, O.) Endocrine-Related Cancer; 6, 211-218, 1999

98. Identification of cis-acting elements in the proximal promoter region for the brain specific exon 1 of the mouse aromatase gene. (Honda, S., Harada, N., Abe-Dohmae, S., & Takagi, Y.) Mol. Brain Res.; 66, 122-132, 1999

99.  Aromatase and sex steroid receptors in human vena cava. (Sasano, H., Murakami, H., Shizawa, S., Satomi, S., Nagura, H., & Harada, N.) Endocr. J.; 46, 233-242, 1999

100. Localized expression of aromatase in human vascular tissues. (Harada, N., Sasano, H., Murakami, H., Ohkuma, T., Nagura, H., & Takagi, Y.) Circ. Res.; 84, 1285-1291, 1999

101. An association between lipid peroxidation and a-naphthylisothiocyanate-induced liver injury in rats. (Kongo, M., Ohta, Y., Nishida, K., Harada, N., Ishiguro, I.) Toxicology Lett., 105, 103-110, 1999

102. Significance of steroid sulfatase expression in human breast cancer. (Utsumi, T., Toshimura, N., Maruta, M., Takeuchi, S., Ando, J., Maeda, K., & Harada, N.) Breast Cancer; 6, 298-300, 1999

103. Aromatase and intracrinology of estrogen in hormone-dependent tumors. (Harada, N.) Oncology; 57, 7-15, 1999

104. A GCM motif protein is involved in placenta-specific expression of human aromatase gene. (Yamada, K., Ogawa, H., Honda, S., Harada, N., & Okazaki, T.) J. Biol. Chem.; 274, 32279-32286, 1999

105. Change in hepatic antioxidant defense system with liver injury development in rats with a single naphthylisothiocyanate intoxication. (Ohta, Y., Kongo, M., Sasaki, E., & Harada, N.) Toxicology; 139, 265-275, 1999

106
. Aromatase deficiency caused by a novel P450arom gene mutation: Impact of absent estrogen production on serum gonadotropin concentration in a boy. (Delado惣, J., Fl歡k, C., Bex, M., Yoshimura, N., Harada, N., & Mullis, P.E.) J. Clin. Endocrinol. Metab. ;84, 4050-4054, 1999

107. Accelerated conversion of dehydroepiandrosterone sulfate to estrogen in a patient with Crow-Fukase syndrome and diabetes mellitus. (Mano, T., Mori, K., Sawai, Y., Oda, N., Tugawa, T., Nakano, I., Watanabe, F., Hamada, M., Nakai, A., Yamamoto, H., Harada, N., Nagasaka, A., & Itoh, M. ) Endocr. Res.; 25, 371-380, 1999

108
. 17b-Hydroxysteroid dehydrogenase type 1 and 2 expression in the human fetus. (Takeyama, J., Suzuki, T., Hirasawa, G., Muramatsu, Y., Nagura, H., Iimura, K., Nakamura, J., Kimura, K., Yoshihama, M., Harada, N., Andersson, S., & Sasano, H.) J. Clin. Endocrinol. Metab.; 85, 410-416, 2000

109. Correlation of cyclin D1 mRNA levels with clinicopathological parameters and clinical outcome in human breast carcinoma. (Utsumi, T., Yoshimura, N., Maruta, M., Mizoguchi, Y., & Harada, N.) Int. J. Cancer; 89, 39-43, 2000

110. Genetic variations of Cyp19 (aromatase) and breast cancer risk. (Kristensen, V.N., Harada, N., Yoshimura, N., Haraldsen, E., Lonning, P.E., Erikstein, B., Karesen, R., M., Kristensen, T., & Borresen-Dale, A-L.) Oncogene; 19,1329-1333, 2000

111. Elevated steroid sulfatase expression in breast cancers. (Utsumi, T., Yoshimura, N., Takeuchi, S., Maruta, M., Maeda, K., & Harada, N.) J. Steroid Biochem. Mol. Biol.; 73, 141-145, 2000

112. Protective effect of melatonin against a-naphthylisothiocyanate-induced liver injury in rats. (Ohta, Y., Kongo, M., Sasaki, E., Ishiguro, I., & Harada, N.) J. Pineal Res.; 29, 15-23, 2000

113. Localization and controls of aromatase in the quail spinal cord. (Evrard, H., Baillien, M., Foidart, A., Absil, P., Harada, N., & Balthazart, J.) J. Comp. Neurol.; 423, 552-564, 2000

114. Ontogeny of aromatase and tyrosine hydroxylase activity and of aromatase-immunoreactive cells in the preoptic area of male and female japanese quail. (Balthazart, J., Tlemcani, O., Harada, N., & Baillien, M.) J. Neuroendocrinol.; 12, 853-866, 2000

115. Estrogen secreting adrenal adenocarcinoma in an 18-month-old boy: Aromatase activity, protein expression , mRNA and utilization of gonadal type promoter. (Watanabe, T., Yasuda, T., Noda, H., Wada, K., Kazukawa, I., Someya, T., Minamitani, K., Minagawa, M., Wataki, K., Matsunaga, T., Ohnuma, N., Kohno, Y., & Harada, N.) Endocrine J.; 47, 723-730, 2000

116. Analysis of estrogen receptor a and b in endometrial carcinomas: Crrelation with ERb and clinicopathologic findings in 45 cases. (Utsunomiya, H., Suzuki, T., Harada, N., Ito, K., Matsuzaki, S., Konno, R., Sato, S., Yajima, A., & Sasano, H.) Int. J. Gynecol. Pathol.; 19, 335-341, 2000.

117. Expression and cellular localization of estrogen receptors a and b in the human fetus. (Takeyama, J., Suzuki, T., Inoue, S., Kaneko, C., Nagura, H., Harada, N., & Sasano, H.) J. Clin. Endocrinol. Metab.; 86, 2258-2262, 2001

118. Immunolocalization of steroidogenic enzymes in the corpus luteum and placenta of the Japanese black bear, Ursus thibetanus japonicus, during pregnancy. (Tsubota, T., Taki, S., Nakayama, K., Mason, J. I., Kominami, S., Harada, N., & Kita, I.) Reproduction; 121, 587-594, 2001

119. Brain aromatase is neuroprotective. (Azcoitia, I., Sierra, A., Veiga, S., Honda, S., Harada, N., & Garcia-Segura, L. M.) J. Neurobiol.; 47, 318-29, 2001

120. The analysis of 17b-hydroxysteroid dehydrogenase isozymes in human endometrial hyperplasia and carcinoma. (Utsunomiya, H., Suzuki, T., Kaneko, C., Takeyama, J., Nakamura, J., Kimura, K., Yoshimura, M., Harada, N., Ito, K., Konno, R., Sato, S., Okamura, K., & Sasano, H.) J. Clin. Endocrinol. Metab.; 86, 3436-3443, 2001

121. Inhibitory action of Oren-gedoku-to extract on enzymatic lipid peroxidation in rat liver microsomes. (Hayashi, T., Ohta, Y., Inagaki, S., & Harada, N.) Biol. Pharm. Bull.; 24, 1165-1170, 2001

122. Genetic polymorphism and variability of steroid hormone metabolism: connection with risk of developing breast neoplasms. (Kristensen, VN., Harada, N., Kristensen, T., & Borresen-Dale, AL.) Voprosy Onkologii: 47, 156-159, 2001

123. Immunohistochemical localization of steroidogenic enzymes in the corpus luteum and the placenta of the ribbon seal (Phoca fasciata) and steller sea lion (Eumetopias jubatus). (Ishinazaka, T., Suzuki, M., Yamamoto, Y., Isono, T., Harada, N., Mason, J.I., Watabe, M., Tsunokawa, M., & Ohtaishi, N.) J. Vet. Med. Sci.; 63, 955-959, 2001

124. 17b-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract. (Sano, T., Hirasawa, G., Takeyama, J., Darnel, A.D., Suzuki, T., Moriya, T., Kato, K., Sekine, H., Ohara, S., Shimosegawa, T., Nakamura, J., Yoshihama, M., Harada, N., & Sasano, H.) Clin. Sci.; 101, 485-491, 2001

125. Aromatase in atherosclerotic lesions of human aorta. (Murakami, H., Harada, N., & Sasano, H.) J. Steroid Biochem. Mol. Biol.; 79, 67-74, 2001

126. Analysis of transcriptional regulation of human breast aromatase by in vitro and in vivo studies. (Harada, N., Matsumoto, T., Yoshimura, N., Sakamoto, H., & Honda, S.) J. Steroid Biochem. Mol. Biol.; 79, 151-156, 2001

127. Characterization and purification of a protein binding to the cis-acting element for brain-specific exon 1 of the mouse aromatase gene. (Honda, S., Matsumoto, T., & Harada, N.) J. Steroid Biochem. Mol. Biol.; 79, 255-260, 2001

128. Genetic susceptibility and environmental estrogen-like compounds. (Kristensen, V. N., Kure, E. H., Erikstein, B., Harada, N., & Borresen-Dale, A.) Mutation Res.; 482, 77-82, 2001

129. Estrogen-dependent regulation of the expression of hepatic Cyp2b and 3a isoforms: Assessment using aromatas-deficient mice. (Yamada, H., Gohyama, N., Honda, S., Hara, T., Harada, N., & Oguri, K.) Toxicol. Appl. Pharmacol.; 180, 1-10, 2002

130. Changes in the arginine-vasopressin immunoreactive systems in male mice lacking a functional aromatase gene. (Plumari, L., Viglietti-Panzica, C., Allieri, F., Honda, S., Harada, N., Absil, P., Balthazart, J., & Panzica, G. C.) J. Neuroendocrinol.; 14, 1-13, 2002

131. Semi-quantitative immunohistochemical analysis of aromatase expression in ductal carcinoma in situ of the breast. (Zhang, Z., Yamashita, H., Toyama, T., Hara, Y., Omoto, Y., Sugiura, H., Kobayashi, S., Harada, N., & Iwase, H.) Breast Cancer Res. Treat.; 74, 47-53, 2002

132. Sexual partner preference requires a functional aromatase (Cyp19) gene in male mice. (Bakker, J., Honda, S., Harada, N., & Balthazart, J.) Horm. Behav.: 42, 158-171, 2002

133. A calcium-deficient diet caused decreased bone mineral density and secondary elevation of estrogen in aged male rats-effect of menatetrenone and elcatonin. (Kato, S., Mano, T., Kobayashi, T., Yamazaki, N., Himeno, Y., Yamamoto, K., Itoh, M., Harada, N., & Nagasaka, A.) Metabolism:51, 1230-4, 2002

134. The aromatase knock-out mouse provides new evidence that estradiol is required during development in the female for the expression of Sociosexual behaviors in adulthood. (Bakker, J., Honda, S., Harada, N., & Balthazart, J.) J. Neurosci.; 22, 9104-9112, 2002

135. Distribution of aromatase immunoreactivity in the forebrain of the red-sided garter snake. (Krohmer, R. W., Bieganski, G. J., Baleckaitis, D. D., Harada, N., Balthazart, J.) J. Chem. Neuroanat.: 23, 59-71, 2002

136. Breast carcinoma in women over the age of 85: distinct histological pattern and androgen, oestrogen, and progesterone receptor status. (Honma, N., Sakamoto, G., Akiyama, F., Rsaki, Y., Sawabe, M., Arai, T., Hosoi, T., Harada, N., Younes, M., & Takubo, K.) Histology: 42, 120-127, 2003

137. Forebrain fos responses to reproductively related chemosensory cues in aromatase knockout mice. (Aste, N., Honda, S., & Harada, N.) Brain Res. Bull.: 60, 191-200, 2003

138. Specific innervation of aromatase neurons by substance P fibers in the dorsal horn of the spinal cord in quail. (Evrard, H.C., Willems, E., Harada, N., & Balthazart, J.) J. Comp. Neurol.: 465, 309-318, 2003

139. Age-related neurodegenerative changes in the central nervous system of estrogen-deficient follitropin receptor knockout mice. (Danilovich, N., Harada, N., Sairam, M.R., & Maysinger, D.) Exp. Neurol.: 183, 559-572, 2003

140. Unique regulation of expression of human aromatase in the placenta. (Harada, N., Yoshimura, N., & Honda, S.,) J. Steroid Biochem. Mol. Biol.: 86, 327-334, 2003

141. Neurological effects of aromatase deficiency in the human. (Matsumoto, T., Honda, S., & Harada, N.) J. Steroid Biochem. Mol. Biol.: 86, 357-365, 2003

142. Alteration in sex-specific behaviors in male mice lacking the aromatase gene. (Matsumoto, T., Honda, S., & Harada, N.) Neuroendocrinology: 77, 416-424, 2003

過去20年間の研究業績-2/3(1983-2003年)

過去20年間の研究業績-3/3(1983-2003年)

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