US/JAPAN Neurosteroid Symposium
2008
MONDAY: September 8, 2008
6:00 – 7:00 PM Plenary
Lecture: Nagaragawa Convention Center
(L1) Arthur Arnold (UCLA): Sex Chromosomes and Brain Gender
7:00 – 9:00 Evening
Reception: Nagaragawa Convention Center
TUESDAY: September 9, 2008
8:00 – 8:10 AM Welcome Address
Nobuhiro Harada (Fujita Health Univ.)
SESSION 1: Classical Mechanisms of Sex Steroid Hormone Action in the Brain: Transcriptional Regulation and Cellular Functions Session Chair: Mitsuhiro Kawata (Kyoto Pref. Univ. Med.) 8:10 - 8:40 AM: (S1) Shinji Hayashi (Tokyo Metroplitan Inst. Neurosci.): Short history of US-Japan seminar since 1972
8:40 - 9:10:
(S2) Marc Tetel (Wellsley College):
Nuclear receptor coactivators: New players in steroid hormone action in brain
and behavior
9:10 - 9:40: (S3) Melinda
Wilson
(Univ. Kentucky): Regulation of estrogen receptor gene expression: New insights
and novel mechanisms
9:40 - 10:10: (S4) Shaila Mani (Baylor Univ.): Steroid
hormone action in the brain: A tale of multiple signaling pathways
10:10 - 10:30: Break
SESSION 2: Alternative
Mechanisms of Steroid Hormone Action in the Brain: Rapid Membrane Responses
Session Chair: Kazuyoshi Tsutsui
(Waseda Univ.)
10:30 - 11:00 AM: (S5) Paul
Micevych
(UCLA): Physiology of membrane estrogen receptor signaling
11:00 - 11:30: (S6) Paul
Mermelstein (Univ. Minnesota): Rapid membrane effects of estrogen via activation of
metabotropic glutamate receptors
11:30 - 12:00: (S7) Shogo Haraguchi (Waseda
Univ.): Rapid
stimulation of locomotor activity by 7a-hydroxypregnenolone
identified as a novel neuronal activator
12:00 - 12:30: (S8) Martin
Kelly (Oregon
Health Sciences Univ.): Rapid estrogen signaling in the hypothalamus: Effects on
neuronal excitability and gene transcription
12:30
- 1:45: Lunch – Large Conference Room
SESSION 3: Novel
Neuropeptides and their Receptors in the Control of Reproduction
Session
Chair: Ei Terasawa (Univ.
Wisconsin)
1:45 - 2:15 PM: (S9) Kazuyoshi
Tsutsui (Waseda Univ.): A new key neurohormone controlling reproduction,
gonadotropin-inhibitory hormone (GnIH) in birds: discovery, progress and
prospect
2:15 - 2:45: (S10) George
Bentley
(UC-Berkeley): Modes of action of gonadotropin inhibitory hormone
2:45 - 3:15: (S11) Donald
Skinner
(Univ. Wyoming): GnRH receptors outside the hypothalamo-pituitary-reproductive
axis
3:15 - 3:45: Break
3:45 - 4:15: (S12) Yoshihisa
Uenoyama (Nagoya Univ.): Kisspeptin/metastin: A key molecule
controlling two modes of GnRH/LH release in female rats
4:15 - 4:45: (S13) T. John Wu (Uniformed Services
Univ.): A biological role for the metabolite of luteinizing
hormone-releasing hormone (LHRH), LHRH-(1-5)
5:30 – 8:00 PM: Reception and Poster Session:
Nagaragawa Convention
Center – Large Conference Room
WEDNESDAY September 10, 2008
SESSION 4: Regulation of GnRH neurons and Central Control of Steroid Hormone Secretion
Session Chair: Joan King 8:30 - 9:00 AM: (S14) Masakatsu Kato (Nippon Med. School): Calcium channels and potassium channels in rat GnRH neurons
9:00 - 9:30: (S15) Ei
Terasawa (Univ.
Wisconsin): The role of G-protein coupled
receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons
9:30 - 10:00: (S16) Hiroyuki
Minakata
(SUNBOR): GnRH and steroids in the cephalopod
reproductive system
10:00 - 10:30: (S17) Suzanne
Moentor
(Univ. Virginia): Neurobiological mechanisms underlying estradiol negative and
positive feedback regulation of GnRH neurons
10:30 - 10:50: Break
10:50 - 11:20: (S18) Yoshitaka
Oka (Univ. Tokyo): Three types of GnRH neurons and steroid-sensitive sexually
dimorphic kisspeptin neurons in teleosts
11:20 – 11:50: (S19) Patrick Chappell (Univ. Oregon):
Modulation
of GnRH secretion
by an endogenous circadian clock
11:50 - 12:20: (S20) Yuji Mori (Univ. Tokyo): Modulation of GnRH pulse generator activity by the pheromone in small ruminants
12:20 - 1:45: Lunch – Large Conference Room
SESSION
5: Steroid Hormone Metabolism and
Novel Mechanisms of Steroid Hormone Action.
Session Chair: Shinji Hayashi (Tokyo Metroplitan Inst.
Neurosci.)
1:45 - 2:15 PM: (S21) Robert
Handa (Univ. Arizona): A role for the androgen metabolite,
3-beta diol, in modulating estrogen receptor beta mediated brain functions
2:15 - 2:45: (S22) Koh
Shinoda
(Yamaguchi Univ.): Histochemical correlation between brain aromatase and
nuclear/membrane sex-steroid receptors in expression and regulation
2:45 - 3:15: (S23) Charles Roselli (Oregon Health and
Sciences Univ.): Prenatal programming of sexual partner preference: The ram
model
3:15 -3:45: Break
3:45 - 4:15: (S24) Suguru
Kawato
(Univ. Tokyo): Rapid modulation of synaptic plasticity by hippocampus-derived
estrogens: Synaptocrinology
4:15 - 4 :45: (S25)
Nobuhiro Harada (Fujita Health Univ.): Functional analysis of neurosteroidal estrogen
by gene-disrupted and transgenic mice
4:45 - 5:15: (S26) Shinji Tsukahara (Nat. Inst.
Environmental Studies): Sex difference in apoptosis and role of estrogen in the
sexually dimorphic nucleus of the preoptic area (SDN-POA) in postnatal rats
(Poster unmount)
6:30 - 9:30 PM: Reception
and Banquet: Gifu Miyako Hotel main banquet Room 【 Ball Room
C 】
Plenary
Lecture:
(L2) Allan Herbison (Univ. Otago, New Zealand):
Estrogen regulation of the GnRH neuron
THURSDAY September 11, 2008
SESSION 6: Developmental Effects of Steroid Hormones: Sexual Differentiation of the Brain
Session Chair: Geert DeVries (U. Mass Amherst)
8:10 - 8:40 AM: (S27) Masugi Nishihara (Univ. Tokyo): Involvement of progranulin in sexual differentiation and neurogenesis in the brain
8:40 - 9:10: (S28) Stuart Tobet (Colorado State Univ.): Brain sex differences and hormone influences: A moving experience?
9:10 - 9:40: (S29) Kataaki Okubo (Uviv. Tokyo): Female-predominant expression of cyp19a2 in the brain of a teleost, medaka
9:40 - 10:10: (S30)
Nancy Forger (U Mass., Amherst): Control of cell number
in the sexually dimorphic brain
10:10 - 10:30: Break
10:30 - 11:00: (S31) Dai Mitsushima (Yokohama
City Univ.): Gonadal
steroids maintain 24-h acetylcholine release in the dorsal hippocampus:
organizational and activational effects in behaving rats
11:00 -
11:30: (S32) Kim Wallen (Emory
Univ.): Sexual differentiation of behavior in monkeys: Role of prenatal
hormones
11:30- 12:00: (S33) Ken-ichi Matsuda (Kyoto Pref. Univ. Med.): Sexual differentiation of preoptic area and hypothalamic nuclei in rat
12:00 - 12:30: (S34)
Yasuo Sakuma (Nippon Med. Sch.): Gonadal steroids and brain sex
differentiation
12:30 - 1:45: Lunch - Large Conference Room
SESSION 7: Steroid Hormones and Sex Differences in
Brain and Behavior
Session Chair: Robert Handa (Univ. Arizona)
1:45 - 2:15 PM: (S35)
Sonoko Ogawa (Univ. Tsukuba): Role of two types of estrogen receptors in the
regulation of mouse behavior
2:15 - 2:45: (S36)
Tracy Bale (Univ. Penn): Examining the intersection of sex and stress in
modeling affective disorders
2:45 - 3:15: (S37) Yasuhiko Kondo (Nippon Med. Sch.): Male rat sexual preference can be revered by estrogen action in adults
3:15 - 3:45: Break
3:45 - 4:15: (S38) Anthony Auger (Univ.
Wisconsin): Brain sex differences and the organization of juvenile social play
behavior
4:15 - 4:45: (S39)
Takefumi Kikusui (Azabu University): Behavioral and neurochemical sex differences
in response to early weaning
4:45 - 5:15: (S40) Hirotaka Sakamoto (Kyoto Pref.
Univ.): Gastrin-releasing peptide
system in the spinal cord controls the male sexual behavior
5:15 - 5:45 PM: Closing Remarks
(S41)
Mitsuhiro Kawata (Kyoto Pref. Univ.):
FRIDAY September 12, 2008
Tours of research facilities in the
Nagoya area
Poster Presentations
TUESDAY: September 9, 2008
5:30 – 8:00 PM: Nagaragawa Convention Center – Large
Conference Room
Poster No.(P#) Presenter/Title
(P1)Bhuvana Balasubramanian (Baylor Univ.): Role of
second messenger kinases in the regulation by progesterone in the hypothalamus
of female rats in the facilitation of reproductive behavior
(P2)Troy
Roepke (Oregon
Health and Sciences Univ.): STX, a Selective Membrane Estrogen Receptor
Agonist, Regulates Gene Expression in the Arcuate Nucleus of the Guinea Pig
(P3)Shunji Yamada (Waseda Univ.): Effect
of lateral septum lesions on expression of estrogen receptor α in the rat brain
(P4)Vishwajit Chowdhury (Waseda Univ.): Stimulatory Role of Melatonin in the Release of
Gonadotropin-Inhibitory Hormone (GnIH)
(P5)Allison Roland (Univ. Virginia): Interaction between
androgens and glucose in the regulation of gonadotropin-releasing hormone
(GnRH) neuron activity
(P6)Justyna Pielecka-Fortuna (Univ. Virginia): Kisspeptin increases GABA and
glutamate transmission to gonadotropin-releasing hormone (GnRH) neurons in an
estradiol-dependent manner
(P7)Jenny Clarkson (Univ. Otago, New
Zealand): Induction of kisspeptin-10 expression in the RP3V during development
by estrogen.
(P8)Sasha Kauffman (Univ. Washington): Sex differences in Kiss1 gene expression in the hypothalamus of juvenile mice: implications for the control of puberty onset
(P9)Victor Navarro (Univ. Washington): Dynorphin as a cotransmitter with kisspeptin in the arcuate
nucleus: a critical element in the feedback regulation of GnRH/LH
(P10)Dai Chida
(Int. Med. Center Japan):
Melanocortin receptor 2 is required for adrenal gland development, steroidogenesis and
neonatal gluconeogenesis
(P11)Yasushi Hojo (Univ. Tokyo):
Neurosteroid synthesis and synaptocrinology in the hippocampal synapses
(P12)Michael Weiser (Univ. Arizona):
Enantiomer-specific effects of estrogen receptor beta (ERb) agonist diarylpriopionitrile (DPN) on receptor binding,
transcriptional activation, anxiety-type behaviors, and learned helplessness
(P13)Eiji
Munetsuna
(Hiroshima Univ.): Stimulation effect of retinoic acid on rat hippocampal
estradiol synthesis
(P14)Minoru Hattori (Hiroshima Univ.):
Expression profiles for neurosteroidogenic enzymes in socially isolated rat
hippocampus
(P15)Sunil Dhungel (Nippon Med. Sch.): Conspecific olfactory preferences of male rats
carrying lesions of the medial amygdala or the preoptic area
(P16)Shin-ichiro Honda (Fujita Health Univ.): Functional analyses of the transcription factors for the
regulation of the brain-specific aromatase gene expression
(P17)Kristy McClellan (Colorado State Univ.):
Relationship among GABA, brain derived neurotrophic factor, and nitric oxide:
Potential effector molecules for the development of the paraventricular nucleus
(P18)Takefumi
Kikusui (Azabu Univ.): Sex difference in response to early
weaning is reversed by prenatal androgen treatment
(P19)Mumeko Tsuda (Univ. Tsukuba): Peri-pubertal expression
of aggression in maternally separated estrogen receptor b knockout male mice
(P20)Kazuhiro Sano (Univ. Tsukuba):
Estrogenic regulation of home-cage running wheel activity in male mice
(P21)Kazuyo Nagata (Univ. Tsukuba): Effects
of selective deletion of the estrogen receptor a expressed in neurons on
socio-sexual behavior in male mice
(P22)Damian Zuloaga (Michigan State
University): The role of the androgen receptor in anxiety-related behaviors and
the hypothalamic pituitary adrenal axis: studies in rodents with the testicular
feminization mutation
(P23)Hiroko Mori (Kyoto Pref. Univ.): Sexual difference and hormonal responsiveness
of the newly identified nucleus in rat hypothalamus
(P24)Keiko Takanami (Kyoto Pref. Univ.): Expression of the G protein-coupled receptor 30, a G protein-coupled membrane estrogen receptor, in rat dorsal root ganglion