kidney Placenta Data

Research TitleMicroarray Analysis of Differentially Expressed Genes in Placental Tissue of Severe Preeclampsia.
InvestigatorHaruki Nishizawa (Fujita Health University, Department of Gynecology)
SummaryPreeclampsia is a multisystemic pregnancy-associated disease affecting about 3-7% of pregnancies worldwide and is still a principal cause of fetal and maternal morbidity and mortality. To identify potential markers, we have compared gene expression profiles from normal and preeclamptic placental tissues taken at various age-matched gestational stages using complementary DNA microarray analysis. Placental biopsies were obtained during Caesarean section from both normotensive patients (n = 4) and from those with pre-eclampsia (n = 10) (early onset type; earlier than 31 weeks gestation, n = 5 and late onset type; 31 weeks gestation or later, n = 5). Pre-eclampsia was defined as a blood pressure of higher than 160/110 mmHg, with proteinuria of more than 2g in a 24 hour collection. The expression profiles of approximately 47,669 genes were analyzed using a Whole Human Genome Oligo Microarray Kit (Agilent Technologies).
OrganismHomo sapiens
Data Description

Data (Downloadable) Help nl-1
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Experimental Design
GEO Series Accession No.GSE4707



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