研究者データベース
名前：	伊藤　 祥輔(Shosuke Ito)
研究分野のKeyword：	メラニン　ニューロメラニン　メラノーマ　　高速液体クロマトグラフィー
専門：	化学 有機化学
電子メールアドレス：	sito@fujita-hu.ac.jp

研究分野情報 (#1)
研究分野-1：	分析化学
研究課題-1：	メラニンの化学的分析
研究分野情報 (#2)
研究分野-2：	皮膚科学
研究課題-2：	紫外線とメラニン メラニン形成の生化学 メラノーマの生化学的マーカー メラノーマの化学療法
研究分野情報 (#3)
研究分野-3：	神経科学
研究課題-3：	ニューロメラニンの生化学

所属機関/組織 (#1)
所属機関名-1：	藤田保健衛生大学
所属部署名(1) 1：	衛生学部　衛生技術学科
役職・職名-1：	教授
郵便番号-1：	470-1192
住所-1：	愛知県豊明市沓掛町田楽ヶ窪1-98
電話番号-1：	0562-93-2595
FAX番号-1：	0562-93-4595

所属学会／研究会 (#1)
所属学会名-1：	日本化学会
所属学会／研究会 (#2)
所属学会名-2：	日本がん学会
所属学会／研究会 (#3)
所属学会名-3：	日本色素細胞学会
所属学会役員・委員会等-3：	理事
所属学会／研究会 (#4)
所属学会名-4：	ヨーロッパ色素細胞学会
所属学会役員・委員会等-4：	名誉会員
所属学会／研究会 (#5)
所属学会名-5：	パンアメリカン色素細胞学会
所属学会／研究会 (#6)
所属学会名-6：	国際研究皮膚科学会

研究歴／実績 [2004年] (#11)
論文-11：	Naysmith L, Waterston K, Ha T, Flanagan N, Bisset Y, Ray A., Wakamatsu K, Ito S, Rees JL. Quantitative measures of the effect of the melanocortin 1 receptor (MC1R) on human pigmentary status. J Invest Dermatol 122: 423-428, 2004. Yukitake J, Otake H, Inoue S, Wakamatsu K, Ito S. Comparison of in vivo anti-melanoma effect of enantiometic alpha-methyl- and alpha-ethyl-4-S-cysteiaminylphenol. Melanoma Res 14: 115-120, 2004. McGraw KJ, Ito S, Wakamatsu K, Nolan PM, Jouventin P, Dobson FS, Austic RE, Safran RJ, Stiefferman LM, Hill GE, Parker RS. "You cannot always judge a plumage pigment by its color": carotenoid and melanin content of yellow- and brown-colored feathers in swallows, bluebirds, penguins, and domestic chicks. The Condor 106: 390-395, 2004. Liu Y, Hong L, Kemp VR, Wakamatsu K, Ito S, Simon JD. Ion-exchange and adsorption of Fe(III) by sepia melanin. Pigment Cell Res 17: 262-269, 2004. Hayashi H, Sone M, Ito S, Wakamatsu K, Kato M, Nakashima I, Nakashima T. A novel RFP-RET transgenic model with abundant eumelanin in the cochlea. Hearing Res 195: 35-40, 2004. Rad HH, Yamashita T, Jin HY, Hirosaki K, Wakamatsu K, Ito S, Jimbow K. Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells. Exp Cell Res 298: 317-328, 2004. Hirobe T, Takeuchi S, Hotta E, Wakamatsu K, Ito S. Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis. Pigment Cell Res 17: 506-514, 2004. Nakatsura T, Kageshita T, Ito S, Wakamatsu K, Monji M, Ikuta Y, Senju S, Ono T, Nishimura Y. Identification of glypican-3 as a novel tumor marker for melanoma. Clin Cancer Res 10: 6612-6621, 2004. Takeuchi S, Zhang W, Wakamatsu K, Ito S, Hearing VJ, Kraemer KH, Brash DE. Melanin acts as a potent UVB photosensitizer to cause a novel mode of cell death in murine skin. Proc Natl Acad Sci USA 101: 15076-15081, 2004. Zucca FA, Giaveri G, Gallorini M, Alberini A, Toscani M, Locius R, Wilms H, Sulzer D, Ito S, Wakamatsu K, Zecca L. The neuromelanin of human substantia nigra: physiological and pathogenic aspects. Pigment Cell Res 17: 610-617, 2004. Simon JD, Ito S. The chemical structure of melanin. Reply. Pigment Cell Res 17: 423-424, 2004.
Papers-11：	Naysmith L, Waterston K, Ha T, Flanagan N, Bisset Y, Ray A., Wakamatsu K, Ito S, Rees JL. Quantitative measures of the effect of the melanocortin 1 receptor (MC1R) on human pigmentary status. J Invest Dermatol 122: 423-428, 2004. Yukitake J, Otake H, Inoue S, Wakamatsu K, Ito S. Comparison of in vivo anti-melanoma effect of enantiometic alpha-methyl- and alpha-ethyl-4-S-cysteiaminylphenol. Melanoma Res 14: 115-120, 2004. McGraw KJ, Ito S, Wakamatsu K, Nolan PM, Jouventin P, Dobson FS, Austic RE, Safran RJ, Stiefferman LM, Hill GE, Parker RS. "You cannot always judge a plumage pigment by its color": carotenoid and melanin content of yellow- and brown-colored feathers in swallows, bluebirds, penguins, and domestic chicks. The Condor 106: 390-395, 2004. Liu Y, Hong L, Kemp VR, Wakamatsu K, Ito S, Simon JD. Ion-exchange and adsorption of Fe(III) by sepia melanin. Pigment Cell Res 17: 262-269, 2004. Hayashi H, Sone M, Ito S, Wakamatsu K, Kato M, Nakashima I, Nakashima T. A novel RFP-RET transgenic model with abundant eumelanin in the cochlea. Hearing Res 195: 35-40, 2004. Rad HH, Yamashita T, Jin HY, Hirosaki K, Wakamatsu K, Ito S, Jimbow K. Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells. Exp Cell Res 298: 317-328, 2004. Hirobe T, Takeuchi S, Hotta E, Wakamatsu K, Ito S. Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis. Pigment Cell Res 17: 506-514, 2004. Nakatsura T, Kageshita T, Ito S, Wakamatsu K, Monji M, Ikuta Y, Senju S, Ono T, Nishimura Y. Identification of glypican-3 as a novel tumor marker for melanoma. Clin Cancer Res 10: 6612-6621, 2004. Takeuchi S, Zhang W, Wakamatsu K, Ito S, Hearing VJ, Kraemer KH, Brash DE. Melanin acts as a potent UVB photosensitizer to cause a novel mode of cell death in murine skin. Proc Natl Acad Sci USA 101: 15076-15081, 2004. Zucca FA, Giaveri G, Gallorini M, Alberini A, Toscani M, Locius R, Wilms H, Sulzer D, Ito S, Wakamatsu K, Zecca L. The neuromelanin of human substantia nigra: physiological and pathogenic aspects. Pigment Cell Res 17: 610-617, 2004. Simon JD, Ito S. The chemical structure of melanin. Reply. Pigment Cell Res 17: 423-424, 2004.
研究歴／実績 [2005年] (#12)
論文-12：	Liu Y, Hong L, Wakamatsu K, Ito S, Adhyaru B, Bowers CR, Simon JD. Comparison of structural and chemical properties of black and red human hair melanosomes. Photochem Photobiol 81: 135-144, 2005. Machida Y, Chiba T, Takayanagi A, Tanaka Y, Chiba T, Asanuma M, Ogawa N, Koyama A, Iwatsubo T, Ito S, Jansen PH, Shimizu N, Takana K, Mizuno Y, Hattori N. Common anti-apoptotic roles of parkin and alpha-synclein in human dopaminergic cells. Biochem Biophys Res Commun 332: 233-240, 2005. Adachi K, Wakamatsu K, Ito S, Miyamoto N, Nishioka T, Hirata T. An oxygen transporter hemocyanin acts on the late pathway of melanin synthesis. Pigment Cell Res 18: 214-219, 2005. Hennessy A, Oh C, Diffey B, Wakamatsu K, Ito S, Rees J. Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation. Pigment Cell Res 18: 220-223, 2005. Liu Y, Hong L, Wakamatsu K, Ito S, Adhyaru BB, Bowers CR, Simon JD. Comparisons of the structural and chemical properties of melanosomes isolated from RPE, iris and choroids of newborn and mature bovine eyes. Photochem Photobiol 81: 510-516, 2005. Chintala S, Li W, Lamoreux ML, Ito S, Wakamatsu K, Sviderskoya EV, Bennett DC, Park Y-M, Gahl WA, Huizing M, Spritz RA, Ben S, Novak EK, Tan J, Swank RT. Slc7a11 controls the production of pheomelanin pigment and the proliferation of cultured cells. Proc Natl Acad Sci USA 102: 10964-10969, 2005. Costin G-E, Valencia JC, Wakamatsu K, Ito S, Solano F, Milac AL, Viera WD, Yamaguchi Y, Rouzaud F, Petrescu AJ, Lamoreux ML, Hearing VJ. Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis but do not affect intracellular trafficking of the mutant protein. Biochem J 391: 249-259, 2005. Yang Y, Gehrke S., Haque ME, Imai Y, Kosek J, Yang L, Beal MF, Nishimura I, Wakamatsu K, Ito S, Takahashi R, Lu B. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and P13K/Akt signaling. Proc Natl Acad Sci USA 102: 13670-13675, 2005. Adachi K, K. Kato, Wakamatsu K, Ito S, Ishimura K, Hirata T, Murata O, Kumai H. The colorimetric evaluation, histological analysis and chemical quantification of melanin content in "suntanned" fish. Pigment Cell Res 18: 465-468, 2005 Ikuta Y, Nakatsura T, Kageshita T, Fukushima S, Ito S, Wakamatsu K, Baba H, Nishimura Y. Highly sensitive diagnosis of melanoma at an early stage by detecting the serum SPARC and glypican-3 levels. Clin Cancer Res 11: 8079-8088, 2005.
Papers-12：	Liu Y, Hong L, Wakamatsu K, Ito S, Adhyaru B, Bowers CR, Simon JD. Comparison of structural and chemical properties of black and red human hair melanosomes. Photochem Photobiol 81: 135-144, 2005. Machida Y, Chiba T, Takayanagi A, Tanaka Y, Chiba T, Asanuma M, Ogawa N, Koyama A, Iwatsubo T, Ito S, Jansen PH, Shimizu N, Takana K, Mizuno Y, Hattori N. Common anti-apoptotic roles of parkin and alpha-synclein in human dopaminergic cells. Biochem Biophys Res Commun 332: 233-240, 2005. Adachi K, Wakamatsu K, Ito S, Miyamoto N, Nishioka T, Hirata T. An oxygen transporter hemocyanin acts on the late pathway of melanin synthesis. Pigment Cell Res 18: 214-219, 2005. Hennessy A, Oh C, Diffey B, Wakamatsu K, Ito S, Rees J. Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation. Pigment Cell Res 18: 220-223, 2005. Liu Y, Hong L, Wakamatsu K, Ito S, Adhyaru BB, Bowers CR, Simon JD. Comparisons of the structural and chemical properties of melanosomes isolated from RPE, iris and choroids of newborn and mature bovine eyes. Photochem Photobiol 81: 510-516, 2005. Chintala S, Li W, Lamoreux ML, Ito S, Wakamatsu K, Sviderskoya EV, Bennett DC, Park Y-M, Gahl WA, Huizing M, Spritz RA, Ben S, Novak EK, Tan J, Swank RT. Slc7a11 controls the production of pheomelanin pigment and the proliferation of cultured cells. Proc Natl Acad Sci USA 102: 10964-10969, 2005. Costin G-E, Valencia JC, Wakamatsu K, Ito S, Solano F, Milac AL, Viera WD, Yamaguchi Y, Rouzaud F, Petrescu AJ, Lamoreux ML, Hearing VJ. Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis but do not affect intracellular trafficking of the mutant protein. Biochem J 391: 249-259, 2005. Yang Y, Gehrke S., Haque ME, Imai Y, Kosek J, Yang L, Beal MF, Nishimura I, Wakamatsu K, Ito S, Takahashi R, Lu B. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and P13K/Akt signaling. Proc Natl Acad Sci USA 102: 13670-13675, 2005. Adachi K, K. Kato, Wakamatsu K, Ito S, Ishimura K, Hirata T, Murata O, Kumai H. The colorimetric evaluation, histological analysis and chemical quantification of melanin content in "suntanned" fish. Pigment Cell Res 18: 465-468, 2005 Ikuta Y, Nakatsura T, Kageshita T, Fukushima S, Ito S, Wakamatsu K, Baba H, Nishimura Y. Highly sensitive diagnosis of melanoma at an early stage by detecting the serum SPARC and glypican-3 levels. Clin Cancer Res 11: 8079-8088, 2005.
受賞歴-12：	レーパーメダル（国際色素細胞学会学術賞）
Award-12：	The Henry Stanley Raper Medal (International Federation of Pigment Cell Societies Scientific Award)
研究歴／実績 [2006年] (#13)
論文-13：	Beppu H, Shimpo K, Chihara T, Tamai I, Nomoto-Yamaji S, Ozaki S, Ito S, Kuzuya H. Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets. Phytomedicine 13:49-60 2006. Wakamatsu K, Kavanagh R, kadekaro AL, Terzieva S, Sturm R, Leachman S, Abdel-Malek A, Ito S. Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin. Pigment Cell Res 19: 154-162, 2006. Wakamatsu K, Takasaki A, KagedalB, Kageshita T, Ito S. Determination of eumelanin in human urine. Pigment Cell Res 19: 163-169, 2006. Hirobe T, Wakamatsu K, Ito S, Kawa Y, Soma Y, Mizoguchi M. The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes. Europ J Cell Biol 85: 537-549, 2006. Hauser J, Kadekaro AN, Kavanagh RJ, Wakamatsu K, Terzieva S, Schwemberger S, Babcock G, Ito S, Abdel-Malek AZ. Melanin content and the MC1R genotype independently affect UVR-induced DNA damage in cultured human melanocytes. Pigment Cell Res 19: 303-314, 2006. Gautam R, Novak EK, Tan J, Wakamatsu K, Ito S, Swank RT. Interaction of Hermansky-Pudlak syndrome genes in the regulation of lysosome-related organelles. Traffic 7: 779-792, 2006. D!#%ap!#%Orazio JA, Nobuhisa T, Cui R, Arya M, Nishimura E, Spry M, Wakamatsu K, Granter S, Ito S, Fisher DE. Critical role for MC1R in UV tanning: molecular mimicking and skin protection. Nature, 443: 340-344, 2006. Wakamatsu K, Ito S. Evaluation of melanin-related metabolites as markers of solar ultraviolet radiation. Pigment Cell Res 19: 460-464, 2006. Kadekaro AL, Wakamatsu K, Ito S, Abdel-Malek ZA. Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair. Frontiers in Bioscience 11: 2157-2173. 2006. Ito S. Encapsulation of a reactive core in neuromelanin. Proc Natl Acad Sci (USA) 103: 14647-14648, 2006.
Papers-13：	Beppu H, Shimpo K, Chihara T, Tamai I, Nomoto-Yamaji S, Ozaki S, Ito S, Kuzuya H. Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets. Phytomedicine 13:49-60 2006. Wakamatsu K, Kavanagh R, kadekaro AL, Terzieva S, Sturm R, Leachman S, Abdel-Malek A, Ito S. Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin. Pigment Cell Res 19: 154-162, 2006. Wakamatsu K, Takasaki A, KagedalB, Kageshita T, Ito S. Determination of eumelanin in human urine. Pigment Cell Res 19: 163-169, 2006. Hirobe T, Wakamatsu K, Ito S, Kawa Y, Soma Y, Mizoguchi M. The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes. Europ J Cell Biol 85: 537-549, 2006. Hauser J, Kadekaro AN, Kavanagh RJ, Wakamatsu K, Terzieva S, Schwemberger S, Babcock G, Ito S, Abdel-Malek AZ. Melanin content and the MC1R genotype independently affect UVR-induced DNA damage in cultured human melanocytes. Pigment Cell Res 19: 303-314, 2006. Gautam R, Novak EK, Tan J, Wakamatsu K, Ito S, Swank RT. Interaction of Hermansky-Pudlak syndrome genes in the regulation of lysosome-related organelles. Traffic 7: 779-792, 2006. D!#%ap!#%Orazio JA, Nobuhisa T, Cui R, Arya M, Nishimura E, Spry M, Wakamatsu K, Granter S, Ito S, Fisher DE. Critical role for MC1R in UV tanning: molecular mimicking and skin protection. Nature, 443: 340-344, 2006. Wakamatsu K, Ito S. Evaluation of melanin-related metabolites as markers of solar ultraviolet radiation. Pigment Cell Res 19: 460-464, 2006. Kadekaro AL, Wakamatsu K, Ito S, Abdel-Malek ZA. Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair. Frontiers in Bioscience 11: 2157-2173. 2006. Ito S. Encapsulation of a reactive core in neuromelanin. Proc Natl Acad Sci (USA) 103: 14647-14648, 2006.
書籍-13：	Ito S and Wakamatsu K. Chemistry of Melanins. In: Nordlund JJ, Boissy RE, Hearing VJ, King RA, Oetting WS, Ortonne JP. The Pigmentary System. Sec Ed. Blackwell Publishing, pp. 282-310, 2006.
Books-13：	Ito S and Wakamatsu K. Chemistry of Melanins. In: Nordlund JJ, Boissy RE, Hearing VJ, King RA, Oetting WS, Ortonne JP. The Pigmentary System. Sec Ed. Blackwell Publishing, pp. 282-310, 2006.

Fri Jan 19 23:35:10 JST 2007

Login page
All Page