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研究者データベース
名前: 千田 隆夫(Takao Senda)
研究分野のKeyword: Wntシグナル系 
APC
DLG
専門: 解剖学
細胞生物学
発生生物学
電子メールアドレス: tsenda@fujita-hu.ac.jp

所属機関/組織 (#1)
所属機関名-1: 藤田保健衛生大学
所属部署名(1) 1: 医学部 
所属部署名(2) 1: 解剖学第一講座
役職・職名-1: 教授
郵便番号-1: 470-1192
住所-1: 愛知県豊明市沓掛町田楽ヶ窪1-98
電話番号-1: 0562-93-2443
FAX番号-1: 0562-93-5903

教育情報 (#1)
科目名-1: 解剖学
科目内容-1: 人体肉眼解剖学
神経解剖学
教育方針-1: Minimum requirementをわかりやすく。

所属学会/研究会 (#1)
所属学会名-1: 日本解剖学会
所属学会役員・委員会等-1: 学術評議員
所属学会/研究会 (#2)
所属学会名-2: 日本顕微鏡学会
所属学会役員・委員会等-2: 評議員
所属学会/研究会 (#3)
所属学会名-3: 日本臨床分子形態学会
所属学会役員・委員会等-3: 理事
所属学会/研究会 (#4)
所属学会名-4: 日本癌学会

研究歴/実績 [1995年] (#2)
Papers-2: 1. Senda T, Sugimoto N, Horiguchi Y, Matsuda M (1995) The enterotoxin of Clostridium perfringens type A binds to the presynaptic nerve endings in neuromuscular junctions of mouse phrenic nerve-diaphragm. Toxicon 33 : 499-506.
2. Miyashiro I, Senda T, Matsumine A, Baeg G-H, Kuroda T, Shimano T, Miura S, Noda T, Kobayashi S, Monden M, Toyoshima K, Akiyama T (1995) Subcellular localization of the APC protein : immunoelectron microscopic study of the association of the APC protein with catenin. Oncogene 11:89-96.
3. Yano Y, Sakon M, Kambayashi J, Kawasaki T, Senda T, Tanaka K, Yamada F, Shibata N (1995) Cytoskeletal reorganization of human platelets induced by the protein phosphatase 1/2A inhibitors okadaic acid and calyculin A.
Biochem J 307 : 439-449.
4. Umemoto M, Sakagami M, Fukazawa K, Ashida K, Kubo T, Senda T, Yoneda Y (1995) Hair cell regeneration in the chick inner ear following acoustic trauma: ultrastructural and immunohistochemical studies. Cell Tissue Res 281 : 435-443.
5. Horiguchi Y, Senda T, Sugimoto N, Katahira J, Matsuda M (1995) Bordetella bronchiseptica dermonecrotizing toxin stimulates assembly of actin stress fibers and focal adhesions by modifying the small GTP-binding protein rho.
J Cell Sci 108 : 3243-3251.
研究歴/実績 [1996年] (#3)
Papers-3: 1. Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, Baeg G-H, Kawahara T, Kobayashi S, Okada M, Toyoshima K, Akiyama T (1996) Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 272 : 1020-1023.
2. Katsumi A, Senda T, Yamashita Y, Yamazaki T, Hamaguchi M, Kojima T, Kobayashi S, Saito H (1996) Protein C Nagoya, an elongated mutant of protein C, is retained within the endoplasmic reticulum and is associated with GRP78 and GRP94. Blood 87 : 4164-4175.
3. Senda T, Miyashiro I, Matsumine A, Baeg G-H, Monden T, Kobayashi S, Monden M, Toyoshima K, Akiyama T (1996) The tumor suppressor protein APC colocalizes with β-catenin in the colon epithelial cells. Biochem Biophys Res Commun 223 : 329-334.
4. Matsumine A, Senda T, Baeg G-H, Roy B C, Nakamura Y, Noda M, Toyoshima K, Akiyama T (1996) MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. J Biol Chem 271 : 10341-10346.
研究歴/実績 [1997年] (#4)
Papers-4: 1. Senda T (1997) Intracellular transport and exocytosis of the secretory granules. Acta Anat Nippon 72 : 1-7.
2. Senda T, Horiguchi Y, Umemoto M, Sugimoto N, Matsuda M (1997) Bordetella bronchiseptica dermonecrotizing toxin, which activates a small GTP-binding protein rho, induces membrane organelle proliferation and caveolae formation. Exp Cell Res 230 : 163-168.
3. Senda T, Matsumine A, Akiyama T, Kobayashi S (1997) Association of the MCC gene product with the plasma membrane and membrane organelles. Med Electron Microsc 30 : 1-7.
4. Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, Matsumine A, Kobayashi S, Toyoshima K, Akiyama T (1997) DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. Genes Cells 2 : 415-424.
5. Iida Y, Senda T, Matsukawa Y, Onoda K, Miyazaki J, Sakaguchi H, Nimura Y, Hidaka H, Niki I (1997) Myosin light chain phosphorylation controls insulin secretion at a proximal step in the secretory cascade. Amer J Physiol 273 : E782-E789.
研究歴/実績 [1998年] (#5)
Papers-5: 1. Nakanishi M, Mizuguchi H, Ashihara K, Senda T, Akuta T, Okabe J, Nagoshi E, Masago A, Eguchi A, Suzuki Y, Inokuchi H, Watabe A, Ueda S, Hayakawa T, Mayumi T (1998) Gene transfer vectors based on Sendai virus. J Control Release 54 : 61-68.
2. Senda T, Iino S, Matsushita K, Matsumine A, Kobayashi S, Akiyama T (1998) Localization of the adenomatous polyposis coli tumor suppressor protein in the mouse central nervous system. Neuroscience 83 : 857-866.
3. Yu W, Nakamura A, Nakahari T, Imai Y, Senda T (1998)Classification of the frog lingual gland cells and their exocytotic features. J Electron Microsc 47 : 73-80.
4. Igakura T, Kadomatsu K, Kaname T, Muramatsu H, Fan Q-W, Miyauchi T, Toyama Y, Kuno N, Yuasa S, Takahashi M, Senda T, Taguchi O, Yamamura K, Arimura K, Muramatsu T (1998) A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation
development and spermatogenesis. Dev Biol 194 : 152-165.
5. Kuno N, Kadomatsu K, Fan Q-W, Hagihara M, Senda T, Mizutani S, Muramatsu T (1998) Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily
FEBS Lett 425 : 191-194.
6. Senda T, Umemoto M : Electron microscopic demonstration of chromatin- nuclear matrix association in the nuclei of Triton X-extracted rat anterior pituitary cells. Biomed Res 19 : 83-91.
7. Matsumoto N, Horibe S, Nakamura N, Senda T, Shino K, Ochi T (1998) Effect of the alignment of the transplanted graft extracellular matrix on cellular repopulation and newly synthesized collagen. Arch Orthop Traum Surg 117 : 215-221.
8. Katsumi A, Kojima T, Senda T, Yamazaki T, Tsukamoto H, Sugiura I, Kobayashi S, Miyata T, Umeyama H, Saito H (1998) The carboxyl-terminal region of protein C is essential for its secretion. Blood 91: 3784-3791.
9. Senda T, Yamashita K, Okabe T, Sugimoto N, Matsuda M (1998) Intergranular bridges in the anterior pituitary cell and their possible involvement in Ca2+-induced
granule-granule fusion. Cell Tissue Res 292 : 513-519.
10. Senda T, Yu W, Okabe T, Sugimoto N, Matsuda M (1998) Widespread association of annexin II with intracellular membrane systems and involvement of annexin II in granule-granule fusion in addition to granule-plasma membrane fusion in anterior pituitary cells. Histochem J 30 : 331-338.
11. Fan Q-W, Yuasa S, Kuno N, Senda T, Kobayashi M, Muramatsu T, Kadomatsu K (1998) Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system. Neurosci Res 30 : 53-63.
12. Senda T, Yoshinaga-Hirabayashi T (1998) Intermembrane bridges within membrane organelles revealed by quick- freeze deep-etch electron microscopy. Anat Rec 251 : 339-345.
13. Senda T (1998) Cytoskeletal organization in the neurohypophysial axons of rats. Med Electron Microsc 31 : 94-99.
14. Nahar NS, Torihashi S, Iino S, Senda T, Chowdhury JU, Kobayashi S (1998) Special smooth muscle cells along the submucosal surface of the guinea pig colon with reference to its spontaneous contractions. Cell Tissue Res 293 : 143-154.
15. Niwa T, Matsukawa Y, Senda T, Nimura Y, Hidaka H, Niki I (1998) Acetylcholine activates intracellular movement of insulin granules in pancreatic β-cells via inositol triphosphate-dependent mobilization of intracellular Ca2+
Diabetes 47 : 1699-1706.
研究歴/実績 [1999年] (#6)
Papers-6: 1. Nakanishi M, Mizuguchi H, Ashihara K, Senda T, Eguchi A, Watabe A, Nakanishi T, Kondo M, Nakagawa T, Masago A, Okabe J, Ueda S, Mayumi T, Hayakawa T (1999) Gene delivery systems using the Sendai virus. Mol Memb Biol 16 : 123-127.
2. Senda T, Yu W (1999) Kinesin cross-bridges between neurosecretory granules and microtubules in the mouse neurohypophysis. Neurosci Lett 262 : 69-71.
3. Roy BC, Kuroda T, Mori S, Kohu K, Akiyama T, Senda T (1999) Localization of a novel GAP family protein SPAL in the rat esophagus and heart. Med Electron Microsc 32 : 20-24.
4. Ohta S, Muramatsu H, Senda T, Zou K, Iwata H, Muramatsu T (1999) Midkine is expressed during repair of bone fracture and promotes chondrogenesis. J Bone Miner Res 14 : 1132-1144.
5. Senda T, Matsumine A, Yanai H, Akiyama T : Localization of MCC (mutated in colorectal cancer) in various tissues of mice and its involvement in cell differentiation. J Histochem Cytochem 47 : 1149-1158.
6. Satoh K, Morishita T, Haraguchi K, Kakinuma N, Akiyama T, Senda T (1999) Expression and localization of the LGN protein in the mouse brain with reference to its relationship with Gαi2. Med Electron Microsc 32 : 221-225.
研究歴/実績 [2000年] (#7)
Papers-7: 1. Yu W, Niwa T, Fukasawa T, Hidaka H, Senda T, Sasaki Y, Niki I (2000) Synergism of protein kinase A, protein kinase C, and myosin light-chain kinase in the secretory cascade of the pancreatic β-cell. Diabetes 49 : 945-952.
2. Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O, Akiyama T (2000) Asef, a link between the tumor suppressor APC and G-protein signaling. Science 289 : 1194-1197.
3. Kohu K, Roy BC, Kuroda T, Kakinuma N, Akiyama T, Senda T (2000) Localization of the novel GAP family protein SPAL in epithelial cells. Acta Histochem Cytochem 33 : 451-455.
4. Kakinuma N, Nishimura Y, Akiyama T, Senda T (2000) APC is colocalized with β-catenin and hDLG in the Henle’s loop of the mouse kidney. Acta Histochem Cytochem 33 : 457-463.
研究歴/実績 [2001年] (#8)
Papers-8: 1. Nakanishi M, Akuta T, Nagoshi E, Eguchi A, Mizuguchi H, Senda T (2001) Nuclear targeting of DNA. Eur J Pharmaceutical Sci 13 : 17-24.
2. Fan Q-W, Yu W, Senda T, Yanagisawa K, Michikawa M (2001)
Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. J Neurochem 76 : 391-400.
3. Niwa T, Fukasawa T, Yu W, Nimura Y, Senda T, Ohgawara H, Niki I (2001) Characterization of secretory and morphologic properties of primary cultured endocrine cells from porcine pancreata. Pancreas 22 : 135-140.
4. Eguchi A, Akuta T, Okuyama H, Senda T, Yokoi H, Inokuchi H, Fujita S, Hayakawa T, Takeda K, Hasegawa M, Nakanishi M (2001) Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells. J Biol Chem 276 : 26204-26210.
研究歴/実績 [2002年] (#9)
Papers-9: 1. Niki I, Senda T (2002) Regulation of insulin release at pre-exocytotic stages of the secretory process. Curr Med Chem Imun Endoc & Metab Agents 2 : 219-231.
2. Fan QW, Yu W, Gong J-S, Zou K, Sawamura N, Senda T, Yanagisawa K, Michikawa M (2002) Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons. J Neurochem 80 : 178-190.
3. Tsukamoto Y, Senda T, Nakano T, Nakada C, Hida T, Ishiguro N, Kondo G, Baba T, Sato K, Osaki M, Mori S, Ito H, Moriyama M (2002) Arpp, a new homologue of Carp, is preferentially expressed in type 1 skeletal muscle fibers and is markedly induced by denervation. Lab Invest 82 : 645-655.
4. Yu W, Niwa T, Miura Y, Horio F, Teradaira S, Ribar TJ, Means AR, Hasegawa Y, Senda T, Niki I (2002)
Calmodulin overexpression causes Ca2+-dependent apoptosis of pancreatic cells, which can be prevented by inhibition of nitric oxide synthase. Lab Invest 82 : 1229-1239.
5. Akuta T, Eguchi A, Okuyama H, Senda T, Inokuchi H, Suzuki Y, Nagoshi E, Mizuguchi H, Hayakawa T, Takeda K, Hasegawa M, Nakanishi M (2002) Enhancement of phage-mediated gene transfer by nuclear localization signal.
Biochem Biophys Res Commun 297 : 779-786.
研究歴/実績 [2003年] (#10)
Papers-10: 1. Shimomura A, Nomura R, Senda T (2003) Lithium inhibits apoptosis of mouse neural progenitor cells. Neuroreport 14 : 1779-1782.
2. Niki I, Niwa T, Yu W, Budzko D, Miki T, Senda T (2003)
Ca2+ influx does not trigger glucose-induced traffic of the insulin granules and alteration of their distribution. Exp Biol Med 228: 1218-1226.
3. Senda T, Nomura R (2003) The expression of cytokeratin in hepatic stellate cells of the cod. Arch Histol Cytol 66 : 437-444.
4. Nakanishi M, Eguchi A, Akuta T, Nagoshi E, Fujita S, Okabe J, Senda T, Hasegawa M (2003) Basic peptides as functional components of non-viral gene transfer vehicles.
Current Protein and Peptide Science 4 : 141-150.
研究歴/実績 [2004年] (#11)
Papers-11: 1. Satoh K, Kasai M, Ishidao T, Tago K, Ohwada S, Hasegawa Y, Senda T, Takada S, Nada S, Nakamura T, Akiyama T (2004)
Anteriorization of neural fate by inhibitor of β-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. Proc Natl Acad Sci USA 101 : 8017-8021.
2. Nomura R, Kiyota A, Suzaki E, Kataoka K, Ohe Y, Miyamoto K, Senda T, Fujimoto T (2004) Human coronavirus 229E binds to CD13 in rafts and enters the cell through caveolae. J Virol 78 : 8701-8708.
3. Kakizawa H, Itoh Y, Imamura S, Matsumoto T, Ishiwata Y, Ono Y, Yamamoto K, Kato T, Hayakawa N, Oda N, Goto Y, Nagasaka A, Senda T, Itoh M (2004) Possible role of VEGF in the progression of kidney disease in streptozotocin (STZ)-induced diabetic rats: effects of an ACE inhibitor and an angiotensin II receptor antagonist. Horm Metab Res 36 : 458-464.
研究歴/実績 [2005年] (#12)
Papers-12: 1. Senda T, Iizuka-Kogo A, Shimomura A (2005)Visualization of the nuclear lamina in mouse anterior pituitary cells and immunocytochemical detection of lamin A/C by quick-freeze freeze- substitution electron microscopy.
J Histochem Cytochem 53: 497-507.
2. Nomura R, Aoki T, Hagiwara H, Senda T, Fujimoto T (2005)
Anti-calreticulin antibody binds to a membrane protein in caveolae. Acta Histochem Cytochem 38: 43-52.
3. Tsunekawa S, Miura Y, Yamamoto N, Itoh Y, Ariyoshi Y, Senda T, Oiso Y, Niki I (2005) Systemic administration of pituitary adenylate cyclase-activating polypeptide maintains beta-cell mass and retards onset of hyperglycaemia in beta-cell-specific calmodulin-overexpressing transgenic mice. Eur J Endocrinol 152: 805-811.
4. Sumi-Ichinose C, Urano F, Shimomura A, Sato T, Ikemoto K, Shiraishi H, Senda T, Ichinose H, Nomura T (2005)
Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities. J Neurochem 95 : 703-714.
5. Nakamura K, Senda T, Sato K, Mori S, Moriyama M
Accumulation of BCL10 at the perinuclear region is required for the BCL10-mediated nuclear factor-kappa B activation. Pathobiology 72 : 191-202.
6. Senda T, Shimomura A, Iizuka-Kogo A (2005) Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. Anatomical Science International 80 : 121-131.
7. Shimomura A, Kohu K, Akiyama T, Senda T (2005)Subcellular localization of the tumor suppressor protein APC in developing cultured neurons. Neurosci Lett 375 : 81-86.
8. Iizuka-Kogo A, Shimomura A, Senda T (2005)Colocalization of APC and DLG at the tips of cellular protrusions in cultured epithelial cells and its dependency on cytoskeletons. Histochem Cell Biol 123: 67-73.

研究歴/実績 [2006年] (#13)
Papers-13: 1. Nasu-Nishimura Y, Hayashi T, Ohishi T, Okabe T, Ohwada S, Hasegawa Y, Senda T, Toyoshima C, Nakamura T, Akiyama T (2006) Role of the Rho GTPase-activating protein RICS in neurite outgrowth. Genes Cell 11: 607-614.
2. Takamori N, Shimomura A, Senda T (2006) Microtubule-bundling activity of APC is stimulated by interaction with PSD-95. Neurosci Lett 403: 68-72.
研究歴/実績 [2007年] (#14)
Papers-14: 1. Senda T, Iizuka-Kogo A, Onouchi T, Shimomura A (2007)Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. Medical Molecular Morphology 40 : 68-81.
2. Iizuka-Kogo A, Ishidao T, Akiyama T, Senda T (2007)Abnormal development of urogenital organs in Dlgh1-deficient mice. Development 134 : 1799-1807.
3. Shimomura A, Ohkuma M, Iizuka-Kogo A, Kohu K, Nomura R, Miyachi E, Akiyama T, Senda T (2007) Requirement of the tumour suppressor APC for the clustering of PSD-95 and AMPA receptors in hippocampal neurons. Eur J Neurosci 26 : 903-912.
4. Hasegawa Y, Satoh K, Iizuka-Kogo A, Shimomura A, Nomura R, Akiyama T, Senda T (2007) Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis. Biochem Biophys Res Commun 362 : 988-994.

Tue Sep 18 21:51:11 JST 2007

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