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Home >  診療グループ紹介 >  感染・血液・腫瘍・神経

感染・血液・腫瘍・神経


感染症分野では主に、HHV-6、ロタウイルス、水痘ワクチンについての臨床ウイルス学的研究を行っています。またHHV-6、ロタウイルスに関しては、各種検査も受け付けています。検査依頼のページをご覧ください。
HHV-6やヘルペスウイルス全般、およびロタウイルスの臨床、研究にご興味のある方の国内留学や共同研究についても積極的に取り組んでゆきたいと考えています。御相談下さい。

血液分野は、名古屋大学小児科に事務局のある小児再生不良貧血治療研究会のメンバーとして、臍帯血移植や2回目移植を担当して解析を進め、小児再生不良性貧血の臨床研究について取り組んでおります。また、日本小児がん研究グループ(JCCG)のHLH/LCH委員会委員として、血球貪食性リンパ組織球症(HLH)及びランゲルハンス細胞組織球症(LCH)といった希少疾患の病態解明や治療についての相談を受けております。

小児神経分野では患者さんの診療を軸とした臨床研究を行っています。扱う疾患は幅広く、てんかん、急性脳症、脳性麻痺、先天性脳奇形、新生児脳障害などの小児中枢神経疾患や、Guillain-Barre症候群、重症筋無力症、筋ジストロフィー、神経変性疾患、神経皮膚症候群など、多岐に渡ります。感染症分野や血液・腫瘍分野と共同して、下記の研究に取り組んでいます。

スタッフ

  • 吉川哲史(教授)
  • 工藤寿子(教授)
  • 石原尚子(准教授)
  • 田中真己人(講師)
  • 河村吉紀(講師)
  • 三浦浩樹(助教)
  • 三宅未紗(第2教育病院 助教)
  • 小澤慶(助教)
  • 古川源(助教)

業績(過去3年間 英文)

Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis. Miura H, Kawamura Y, Hattori F, Tanaka M, Kudo K, Ihira M, Yatsuya H, Takahashi Y, Kojima S, Sakaguchi H, Yoshida N, Hama A, Yoshikawa T. Transpl Infect Dis. 2020 Feb;22(1):e13203.

Nationwide retrospective review of hematopoietic stem cell transplantation in children with refractory Langerhans cell histiocytosis. Kudo K, Maeda M, Suzuki N, Kanegae H, Ohga S, Ishii E, Shioda Y, Imamura T, Imashuku S, Tsunematsu Y, Endo M, Shimada A, Koga Y, Hashii Y, Noguchi M, Unoue M, Tabuchi K, Morimoto A, on behalf of The Histiocytosis study group of the Japanese Society of Pediatric Hematology/Oncology. International Journal of Hematology (2020) 111:137–148.

Three Cases of Hemiconvulsion-Hemiplegia-Epilepsy Syndrome With Focal Cortical Dysplasia Type IIId. Itamura S, Okanishi T, Arai Y, Nishimura M, Baba S, Ichikawa N, Hirayama Y, Ishihara N, Hiraide T, Ishigaki H, Fukuda T, Otsuki Y, Enoki H,Fujimoto A. Front Neurol. 2019 Nov 20;10:1233.

Human herpesvirus-6B infection in pediatric hematopoietic stem cell transplant recipients: Risk factors and encephalitis. Miura H, Kawamura Y, Hattori F, Tanaka M, Kudo K, Ihira M, Yatsuya H, Takahashi Y, Kojima S, Sakaguchi H, Yoshida N, Hama A, Yoshikawa T Transpl Infect Dis. 2019 Oct 25. doi: 10.1111/tid.

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms or non-drug-related erythroderma with a persistent human herpesvirus 6 infection. Mitsui Y, Ogawa K, Miyagawa F, Azukizawa H, Yoshikawa T, Asada H. J Dermatol. 2019 Nov 6. doi: 10.1111/1346-8138

High prevalence of equine-like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand. Tacharoenmuang R, Komoto S, Guntapong R, Upachai S, Singchai P, Ide T, Fukuda S, Ruchusatsawast K, Sriwantana B, Tatsumi M, Motomura K, Takeda N, Murata T, Sangkitporn S, Taniguchi K, Yoshikawa T. J Med Virol. 2019 Sep 9.

Reliability of direct varicella zoster virus loop-mediated isothermal amplification method for rapid diagnosis of breakthrough varicella. Higashimoto Y, Kawamura Y, Kuboshiki A, Hattori F, Miura H, Nishimura N, Ozaki T, Ihira M, Yoshikawa T, and Nagoya VZV study group. J Clin Virol. 2019 Oct;119:53-58.

Persistent systemic rotavirus vaccine infection in a child with X-linked severe combined immunodeficiency. Yoshikawa T, Ihira M, Hattori F, Miura H, Sugata K, Komoto S, Taniguchi K, Iguchi A, Yamada M, Ariga T. J Med Virol. 2019 ;91(6):1008-1013.

Clinical characteristics of primary HHV-6B infection in children visiting the emergency room. Hattori F, Miura H, Kawamura Y, Miyake M, Kudo K, Kato Y, Yoshikawa A, Ihira M, Yoshikawa T. Pediatr Infect Dis J. 2019 Jun 20. doi: 10.

Hematopoietic stem cell transplantation for pediatric acute myeloid leukemia patients with KMT2A rearrangement; A nationwide retrospective analysis in Japan. Miyamura T, Kudo K, Tabuchi K, Ishida H, Tomizawa D, Adachi S, Goto H, Yoshida N, Inoue M, Koh K, Sasahara Y, Fujita N, Kakuda H, Noguchi M, Hiwatari M, Hashii Y, Kato K, Atsuta Y, Okamoto Y. Leuk Res. 2019 Dec;87:106263.

Clinical effects of recombinant thrombomodulin and defibrotide on sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation. Yakushijin K, Ikezoe T, Ohwada C, Kudo K, Okamura H, Goto H, Yabe H, Yasumoto A, Kuwabara H, Fujii S, Kagawa K, Ogata M, Onishi Y, Kohno A, Watamoto K, Uoshima N, Nakamura D, Ota S, Ueda Y, Oyake T, Koike K, Mizuno I, Iida H, Katayama Y, Ago H, Kato K, Okamura A, Kikuta A, Fukuda T. Bone Marrow Transplant. 2019 May;54(5):674-680.

PRRT2 mutations in Japanese patients with benign infantile epilepsy and paroxysmal kinesigenic dyskinesia. Okumura A, Shimojima K, Kurahashi H, Numoto S, Shimada S, Ishii A, Ohmori I, Takahashi S, Awaya T, Kubota T, Sakakibara T, Ishihara N, Hattori A, Torisu H, Tohyama J, Inoue T, Haibara A, Nishida T, Yuhara Y, Miya K, Tanaka R, Hirose S, Yamamoto T. Seizure. 2019 May 20;71:1-5.

Comparison of conditioning regimens for autologous stem cell transplantation in children with acute myeloid leukemia: A nationwide retrospective study in Japan. Sakaguchi H, Muramatsu H, Hasegawa D, Kudo K, Ishida H, Yoshida N, Koh K, Noguchi M, Shiba N, Tokimasa S, Fukuda T, Goto H, Miyamura T, Nakazawa Y, Hashii Y, Inoue M, Atsuta Y; Pediatric AML Working Group of the Japan Society for Hematopoietic Cell Transplantation. Pediatr Blood Cancer. 2019 Jan;66(1): e27459.

Impact of graft-versus-host disease on relapse and survival after allogeneic stem cell transplantation for pediatric leukemia.Bone Marrow Transplant. Kato M, Kurata M, Kanda J, Kato K, Tomizawa D, Kudo K, Yoshida N, Watanabe K, Shimada H, Inagaki J, Koh K, Goto H, Kato K, Cho Y, Yuza Y, Ogawa A, Okada K, Inoue M, Hashii Y, Teshima T, Murata M, Atsuta Y. Bone Marrow Transplant. 2019 Jan;54(1):68-75.

Secondary cancer after a childhood cancer diagnosis: viewpoints considering primary cancer. Ishida Y, Maeda M, Adachi S, Inada H, Kawaguchi H, Hori H, Ogawa A, Kudo K, Kiyotani C, Shichino H, Rikiishi T, Kobayashi R, Sato M, Okamura J, Goto H, Manabe A, Yoshinaga S, Qiu D, Fujimoto J, Kuroda T. Int J Clin Oncol. 2018 Dec;23(6):1178-1188.

Characterization of a G10P[14] rotavirus strain from a diarrheic child in Thailand: Evidence for bovine-to-human zoonotic transmission. Tacharoenmuang R, Komoto S, Guntapong R, Ide T, Singchai P, Upachai S, Fukuda S, Yoshida Y, Murata T, Yoshikawa T, Ruchusatsawat K, Motomura K, Takeda N, Sangkitporn S, Taniguchi K. Infect Genet Evol. 2018 Sep;63:43-57.

Intensification of induction therapy and prolongation of maintenance therapy did not improve the outcome of pediatric Langerhans cell histiocytosis with single-system multifocal bone lesions: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study. Morimoto A, Shioda Y, Imamura T, Kudo K, Kitoh T, Kawaguchi H, Goto H, Kosaka Y, Tsunematsu Y, Imashuku S; Japan LCH Study Group. Int J Hematol. 2018 Aug;108(2):192-198.

Severe neurocognitive and growth disorders due to variation in THOC2, an essential component of nuclear mRNA export machinery. Kumar R, Gardner A, Homan CC, Douglas E, Mefford H, Wieczorek D, Lüdecke HJ, Stark Z, Sadedin S; Broad CMG, Nowak CB, Douglas J, Parsons G, Mark P, Loidi L, Herman GE, Mihalic Mosher T, Gillespie MK, Brady L, Tarnopolsky M, Madrigal I, Eiris J, Domènech Salgado L, Rabionet R, Strom TM, Ishihara N, Inagaki H, Kurahashi H, Dudding-Byth T, Palmer EE, Field M, Gecz J. Hum Mutat. 2018 Aug;39(8):1126-1138.

Betaherpesvirus Complications and Management During Hematopoietic Stem Cell Transplantation. Yoshikawa T. Adv Exp Med Biol. 2018;1045:251-270.

Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation. Yasui T, Suzuki T, Yoshikawa T, Yatsuya H, Kawamura Y, Miura H, Hara F, Watanabe S, Uga N, Naoe A. Pediatr Transplant. 2018 Jun 3:e13239.

Chromosomally integrated HHV-6 in Japanese population. Miura H, Hattori F, Kawamura Y, Yoshikawa A, Sugata K, Ihira M, Ohye T, Kurahashi H, Yoshikawa T. J Med Virol. 2018 Jun 15.

Generation of recombinant rotaviruses expressing fluorescent proteins using an optimized reverse genetics system. Komoto S, Fukuda S, Ide T, Ito N, Sugiyama M, Yoshikawa T, Murata T, Taniguchi K. J Virol. 2018 Apr 18. pii: JVI.00588-18.

Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6. Greninger AL, Knudsen GM, Roychoudhury P, Hanson DJ, Sedlak RH, Xie H, Guan J, Nguyen T, Peddu V, Boeckh M, Huang ML, Cook L, Depledge DP, Zerr DM, Koelle DM, Gantt S, Yoshikawa T, Caserta M, Hill JA, Jerome KR. BMC Genomics. 2018 Mar 20;19(1):204.

Monitoring shedding of five genotypes of RotaTeq vaccine viruses by genotype-specific real-time RT-PCR assays. Higashimoto Y, Ihira M, Miyazaki Y, Kuboshiki A, Yoshinaga S, Hiramatsu H, Suzuki R, Miyata M, Miura H, Komoto S, Yukitake J, Taniguchi K, Kawamura Y, Yoshikawa T. J Clin Microbiol. 2018 Mar 21. pii: JCM.00035-18.

Late onset human herpesvirus 6B infection in hematopoietic stem cell transplant recipients. Miura H, Kawamura Y, Hattori F, Sugata K, Kudo K, Yatsuya H, Ihira M, Kojima S, Takahashi Y, Yoshikawa T. Transplant Infect Dis 2018 May 24:e12916.

Survey of rotavirus-associated severe complications in Aichi prefecture before and after introduction of rotavirus vaccine. Hattori F, Kawamura Y, Miura H, Sugata K, Yoshikawa T; Aichi Pediatric Clinical Study Group.. Pediatr Int. Pediatr Int. 2018 Mar;60(3):259-263.

Severe myocarditis in an immunocompromised child with respiratory syncytial virus infection. Miura H, Hattori F, Uchida H, Hata T, Kudo K, Sato M, Yoshikawa T. BMC Pediatrics 2018 18(1):51.

Impact of rotavirus vaccination on the burden of acute gastroenteritis in Nagoya city, Japan. Yoshikawa T, Matsuki T, Sato K, Mizuno M, Shibata M, Hasegawa S, Morita M, Iwasa M, Gopala K, Holl K. Vaccine. 2018 ;36(4):527-534.

Cytotoxic edema at onset in West syndrome of unknown etiology: A longitudinal diffusion tensor imaging study. Ogawa , Kidokoro H, Fukasawa T, Yamamoto H, Ishihara N, Ito Y, Sakaguchi Y, Okai Y, Ohno A, Nakata T, Azuma Y, Hattori A, Kubota T,Tsuji T, Hirakawa A, Kawai H, Natsume J. Epilepsia. 2018 Feb;59(2):440-448.

Cytotoxic edema at onset in West syndrome of unknown etiology: A longitudinal diffusion tensor imaging study. Ogawa C, Kidokoro H, Fukasawa T, Yamamoto H, Ishihara N, Ito Y, Sakaguchi Y, Okai Y, Ohno A, Nakata T, Azuma Y, Hattori A, Kubota T, Tsuji T, Hirakawa A, Kawai H, Natsume J. Epilepsia. 2018 Feb;59(2):440-448.

Rotavirus vaccination can be performed without viral dissemination in the Neonatal Intensive Care Unit. Hiramatsu H, Suzuki R, Nagatani A, Boda H, Miyata M, Hattori F, Miura H, Sugata K, Yamada S, Komoto S, Taniguchi K, Ihira M, Nishimura N, Ozaki T, Yoshikawa T. J Infect Dis, J Infect Dis. 2018 Jan 30;217(4):589-596.

Unrelated cord blood transplantation in aplastic anemia: is anti-thymocyte globulin indispensable for conditioning? Kudo K, Muramatsu H, Narita A, Yoshida N, Kobayashi R, Yabe H, Endo M, Inoue M, Hara J, Kounami S, Inagaki J, Hashii Y, Kato K, Tabuchi K, Kojima S. Bone Marrow Transplant. 2017 Dec;52(12):1659-1661.

Allogeneic Hematopoietic Stem Cell Transplantation for Adolescents and Young Adults with Acute Myeloid Leukemia. Tomizawa D, Tanaka S, Kondo T, Hashii Y, Arai Y, Kudo K, Taga T, Fukuda T, Goto H, Inagaki J, Koh K, Ohashi K, Ozawa Y, Inoue M, Kato K, Tanaka J, Atsuta Y, Adachi S, Ishida H. Biol Blood Marrow Transplant. 2017 Sep;23(9):1515-1522.

Inflammatory serum cytokines and chemokines increase associated with the disease extent in pediatric Langerhans cell histiocytosis. Morimoto A, Oh Y, Nakamura S, Shioda Y, Hayase T, Imamura T, Kudo K, Imashuku S; Japan Langerhans cell histiocytosis Study Group. Cytokine. 2017 Sep;97:73-79.

Analysis of the origin of inherited chromosomally integrated human herpesvirus 6 in the Japanese population. Kawamura Y, Ohye T, Miura H, Ihira M, Kurahashi H, Yoshikawa T. J Gen Virol 2017 Jul;98(7):1823-1830.

Evaluating the effectiveness of the universal immunization program agaisnt varicella in Japense children. Hattori F, Miura H, Sugata K, Yoshikawa A, Ihira M, Kamiya H, Taya K, Yoshikawa T, Nagoya VZV study group. Vaccine 2017 Sep 5;35(37):4936-4941.

Development of real-time RT-PCR assays for detection of three classes of HHV-6A gene transcripts. Ihira M, Urashima A, Hirano K, Miura H, Hattori F, Kawamura Y, Sugata K, Yoshikawa T. J Med Virol 2017 Oct;89(10):1830-1836.

Long-term outcomes of 95 children with moderate aplastic anemia treated with horse antithymocyte globulin and cyclosporine. Nishikawa E, Yagasaki H, Hama A, Yabe H, Ohara A, Kosaka Y, Kudo K, Kobayashi R, Ohga S, Morimoto A, Watanabe KI, Yoshida N, Muramatsu H, Takahashi Y, Kojima S. Pediatr Blood Cancer. 2017 May;64(5).

Transmission of chromosomally integrated human herpesvirus 6 via cord blood transplantation. Yamada Y, Osumi T, Imadome KI, Takahashi E, Ohye T, Yoshikawa T, Tomizawa D, Kato M, Matsumoto K. Transpl Infect Dis. 2017 Feb;19(1).

Identification and characterization of a human G9P[23] rotavirus strain from a child with diarrhoea in Thailand: evidence for porcine-to-human interspecies transmission. Komoto S, Tacharoenmuang R, Guntapong R, Ide T, Sinchai P, Upachai S, Fukuda S, Yoshikawa T, Tharmaphornpilas P, Sangkitporn S, Taniguchi K. J Gen Virol. 2017 Apr;98(4):532-538.

Predominant prevalence of human rotaviruses with the G1P[8] and G8P[8] genotypes with a short RNA profile in 2013 and 2014 in Sukhothai and Phetchaboon provinces, Thailand. Guntapong R, Tacharoenmuang R, Singchai P, Upachai S, Sutthiwarakom K, Komoto S, Tsuji T, Tharmaphornpilas P, Yoshikawa T, Sangkitporn S, Taniguchi K. J Med Virol. 2017 Apr;89(4):615-620.