*Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R, Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang B-K, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto K, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato DX, Inoue YU, Inoue T, Komine Y, Yamamori T, Sakimura K, *Miyakawa T. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLife 2024;12:RP89376. doi: 10.7554/eLife.89376.2. (2024 Mar)

Shiraishi T, Katayama Y, Nishiyama M, Shoji H, Miyakawa T, Mizoo T, Matsumoto A, Hijikata A, Shirai T, Mayanagi K, *Nakayama KI. The complex etiology of autism spectrum disorder due to missense mutations of CHD8. Molecular Psychiatry. Online ahead of print. doi: 10.1038/s41380-024-02491-y. (2024 Mar)

Katano T, Konno K, Takao K, Abe M, Yoshikawa A, Miyakawa T, Sakimura K, Watanabe M, Ito S, Kobayashi T. Brain-enriched guanylate kinase-associated protein, a component of the post-synaptic density protein complexes, contributes to learning and memory. Scientific Reports 13(1):22027. doi: 10.1038/s41598-023-49537-9. (2023 Dec)

Temma Y, Obi-Nagata K, Hoshiba Y, Miyake R, Katayama Y, Hagihara H, Suzuki N, Miyakawa T, Nakayama KI, *Hayashi-Takagi A. Effect of brain acidification on depression-related behaviors in diabetes mellitus. Frontiers in Psychiatry 14:1277097. doi: 10.3389/fpsyt.2023.1277097. (2023 Nov)

Kanatsu-Shinohara M, Shiromoto Y, Ogonuki N, Inoue K, Hattori S, Miura K, Watanabe N, Hasegawa A, Mochida K, Yamamoto T, Miyakawa T, Ogura A, Shinohara T. Intracytoplasmic sperm injection induces transgenerational abnormalities in mice. Journal of Clinical Investigation 133(22):e170140. doi: 10.1172/JCI170140. (2023 Nov)

Takahashi Y, *Fujita H, Seino Y, Hattori S, Hidaka S, Miyakawa T, Suzuki A, Waki H, Yabe D, Seino Y, *Yamada Y. Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia. Journal of Cachexia Sarcopenia and Muscle. Online ahead of print. doi: 10.1002/jcsm.13346. (2023 Oct)

*Suzuki T, Hattori S, Mizukami H, Nakajima R, Hibi Y, Kato S, Matsuzaki M, Ikebe R, Miyakawa T, Yamakawa K. Inversed Effects of Nav1.2 Deficiency at Medial Prefrontal Cortex and Ventral Tegmental Area for Prepulse Inhibition in Acoustic Startle Response. Molecular Neurobiology Online ahead of print. doi: 10.1007/s12035-023-03610-6. (2023 Aug)

*Oishi K, Yajima Y, Yoshida Y, Hagihara H, Miyakawa T, Higo-Yamamoto S, Toyoda A. Metabolic profiles of saliva in mouse models of chronic sleep disorders induced by psychophysiological stress. Scientific Reports 13:11156. doi: 10.1038/s41598-023-38289-1. (2023 Jul)

Ping Y, Ohata K, Kikushima K, Sakamoto T, Islam A, Xu L, Zhang H, Chen B, Yan J, Eto F, Nakane C, Takao K, Miyakawa T, Kabashima K, Watanabe M, Kahyo T, Yao I, Fukuda A, Ikegami K, Konishi Y, *Setou M. Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain. Biomolecules 13(5):784. doi: 10.3390/biom13050784. (2023 May)

Darwish M, Hattori S, Nishizono H, Miyakawa T, Yachie N, *Takao K. Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency. Molecular Brain 16(1):44. doi: 10.1186/s13041-023-01033-x. (2023 May)

*Hagihara H, Murano T, *Miyakawa T. The gene expression patterns as surrogate indices of pH in the brain. Frontiers in Psychiatry 14:1151480. doi: 10.3389/fpsyt.2023.1151480. (2023 May)

Mitsuhashi T, Hattori S, Fujimura K, Shibata S, Miyakawa T, *Takahashi T. In utero exposure to valproic acid throughout pregnancy causes phenotypes of autism in offspring mice. Developmental Neuroscience. Online ahead of print. doi: 10.1159/000530452. (2023 Apr)

Shoji H, Ikeda K, *Miyakawa T. Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice. Molecular Brain 16(1):32. doi: 10.1186/s13041-023-01020-2. (2023 Mar)

Iida S, Shoji H, Kawakita F, Nakanishi T, Matsushima Y, Kondo M, Habe K, Suzuki H, Miyakawa T, *Yamanaka K. Inflammatory Skin Disease Causes Anxiety Symptoms Leading to an Irreversible Course. International Journal of Molecular Sciences 24(6):5942. doi: 10.3390/ijms24065942. (2023 Mar)

Kurihara Y, Mitsunari K, Mukae N, Shoji H, Miyakawa T, *Shirane M. PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain. Molecular Brain 16(1):11. doi: 10.1186/s13041-023-01002-4. (2023 Jan)

Hagihara H, Shoji H, Kuroiwa M, Graef IA, Crabtree GR, Nishi A, *Miyakawa T. Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice. Molecular Brain 15(1):94. doi: 10.1186/s13041-022-00981-0. (2022 Nov)

Nagai M, Iemura K, Kikkawa T, Naher S, Hattori S, Hagihara H, Nagata K, Anzawa H, Kugisaki R, Wanibuchi H, Abe T, Inoue K, Kinoshita K, Miyakawa T, *Osumi N, *Tanaka T. Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioral phenotype. Brain Communications fcac220. doi: 10.1093/braincomms/fcac220. (2022 Aug)

Sato DX, Inoue YU, Kuga N, Hattori S, Nomoto K, Morimoto Y, Sala G, Hagihara H, Kikusui T, Sasaki T, Ikegaya Y, Miyakawa T, Inoue T, *Kawata M. Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety. iScience 25(8)104800. doi: 10.1016/j.isci.2022.104800. (2022 Aug)

Murano T, Nakajima R, Nakao A, Hirata N, Amemori S, Murakami A, Kamitani Y, Yamamoto J, *Miyakawa T. Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons. Proceedings of the National Academy of Sciences of the United States of America 119(32):e2106830119. doi: 10.1073/pnas.2106830119. (2022 Aug)

Oota-Ishigaki A, Takao K, Yamada D, Sekiguchi M, Itoh M, Koshidata Y, Abe M, Natsume R, Kaneko M, Adachi T, Kaizuka T, Suzuki N, Sakimura K, Okuno H, Wada K, Mishina M, Miyakawa T, *Hayashi T. Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice. Neuropsychopharmacology Online ahead of print. doi: 10.1038/s41386-022-01347-9. (2022 May)

*Kawai T, Narita H, Konno K, Akter S, Andriani R.T, Iwasaki H, Nishikawa S, Yokoi N, Fukata Y, Fukata M, Wiriyasermkul P, Kongpracha P, Nagamori S, Takao T, Miyakawa T, Abe M, Sakimura K, Watanabe M, Nakagawa A, Okamura Y. Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum. Biochemical Journal 479(11)1127-1145. doi: 10.1042/BCJ20220033. (2022 Jun)

Miyajima K, Sudo Y, Sanechika S, Hara Y, Horiguchi M, Xu F, Suzuki M, Hara S, Tanda K, Inoue K, Takada M, Yoshioka N, Takebayashi H, Mori-Kojima M, Sugimoto M, Sumi-Ichinose C, Kondo K, Takao K, Miyakawa T, *Ichinose H. Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin. Journal of Neurochemistry 162(2)129-145. doi: 10.1111/jnc.15600. (2022 Mar)

Kotajima-Murakami H, Hagihara H, Sato A, Hagino Y, Tanaka M, Kato Y, Nishito Y, Takamatsu Y, Uchino S, Miyakawa T, *Ikeda K. Exposure of GABAA receptor antagonist picrotoxin in pregnant mice causes autism-like behaviors and aberrant gene expression in offspring. Frontiers in Psychiatry 13:821354. doi: 10.3389/fpsyt.2022.821354. (2022 Feb)

Shoji H, Kunugi H, *Miyakawa T. Acute and chronic effects of oral administration of a medium-chain fatty acid, capric acid, on locomotor activity and anxiety-like and depression-related behaviors in adult male C57BL/6J mice. Neuropsychopharmacology Reports 42(1)59–69. doi: 10.1002/npr2.12226. (2022 Jan)

Hagihara H, Shoji H, Otabi H, Toyoda A, Katoh K, Namihira M, *Miyakawa T. Protein lactylation induced by neural excitation. Cell Reports 37(2)109820. doi: 10.1016/j.celrep.2021.109820. (2021 Oct)

Nakajima R, Hagihara H, *Miyakawa T. Similarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila. Molecular Brain 14(1)1-5. doi: 10.1186/s13041-021-00840-4. (2021 Sep)

Nakajima K, Ishiwata M, Weitemier A.Z, Shoji H, Monai H, Miyamoto H, Yamakawa K, Miyakawa T, McHugh TJ, *Kato T. Brain-specific heterozygous loss-of-function of ATP2A2, endoplasmic reticulum Ca2+ pump responsible for Darier’s disease, causes behavioral abnormalities and a hyper-dopaminergic state. Human Molecular Genetics 30(18)1762–1772. doi: 10.1093/hmg/ddab137. (2021 Jun Epub)

*Nagashima S, Ito N, Kobayashi R, Shiiba I, Shimura H, Fukuda T, Hagihara H, Miyakawa T, Inatome R, *Yanagi S. Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3 leads to immature dentate gyri and hyperactivity in mice. Journal of Biological Chemistry 296:100620. doi: 10.1016/j.jbc.2021.100620. (2021 Mar Epub)

Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, *Ichijo H, *Nishitoh H. ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience 24(7)102758. doi: 10.1016/j.isci.2021.102758 (2021 Jul)

Ito N, Riyadh AR, Ahmad SAI, Hattori S, Kanemura Y, Kiyonari H, Abe T, Furuta Y, Shinmyo Y, Kaneko N, Hirota Y, Lupo G, Hatakeyama J, Abdulhaleem FA, Anam MB, Yamaguchi M, Takeo T, Takebayashi H, Tkebayashi M, Oike Y, Nakagata N, Shimamura K, Holtzman MJ, Takahashi Y, Guillemot F, Miyakawa T, Sawamoto K, *Ohta K. Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. Science Translational Medicine 13(587)eaay7896. doi: 10.1126/scitranslmed.aay7896. (2021 Mar)

Hori T, Ikuta S, Hattori S, Takao K, Miyakawa T, *Koike C. Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior. Molecular Brain 14:61. doi: 10.1186/s13041-021-00749-y. (2021 Mar)

Shoji H, *Miyakawa T. Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test. Molecularl Brain 14:34. doi: 10.1186/s13041-020-00721-2. (2021 Feb)

Asada-Utsugi M, Uemura K, Kubota M, Noda Y, Tashiro Y, Uemura TM, Yamakado H, Urushitani M, Takahashi R, Hattori S, Miyakawa T, Ageta-Ishihara N, Kobayashi K, Kinoshita M, *Kinoshita A. Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks. Molecular Brain 14(1)23. doi: 10.1186/s13041-021-00738-1. (2021 Jan)

Kawai T, Takao K, Akter S, Abe M, Sakimura K, Miyakawa T, Okamura Y. Heterogeneity of microglial proton channel in different brain regions and its relationship with aging. Journal of Neurochemistry 157(3)624-641. doi:10.1111/jnc.15292. (2021 Jan)

Kawakami T, Fujisawa H, Nakayama S, Yoshino Y, Hattori S, Seino Y, Takayanagi T, Miyakawa T, Suzuki A, Sugimura Y. Vasopressin escape and memory impairment in a model of chronic syndrome of inappropriate secretion of antidiuretic hormone in mice. Endocrine Journal 68(1)31-43. doi:10.1507/endocrj.EJ20-0289. (2021)

Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Matsumoto H, Miyakawa T, Nakada K. Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics. Pharmacological Research 163:105246. doi:10.1016/j.phrs.2020.105246. (2021 Jan)

Nakajima R, Hattori S, Funasaka T, Huang FL, *Miyakawa T. Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice. Neuropsychopharmacology Reports 41(1)111-116.doi: 10.1002/npr2.12150. (2020 Dec)

Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, *Noriyuki Sugo. Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons. Journal of Neuroscience 40(47) 9012–9027. doi: 10.1523/JNEUROSCI.0319-20.2020. (2020 Nov)

*Shirane M, Shoji H, Hashimoto Y, Katagiri H, Kobayashi S, Manabe T, Miyakawa T, *Nakayama KI. Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning. Molecular Brain 13:146. doi: 10.1186/s13041-020-00693-3. (2020 Nov)

Arima-Yoshida F, Raveau M, Shimohata A, Amano K, Fukushima A, Watanave M, Kobayashi S, Hattori S, Usui M, Sago H, Mataga N, Miyakawa T, *Yamakawa K, *Manabe T. Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABAB receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice. Scientific Reports 10:14187. doi: 10.1038/s41598-020-71085-9. (2020 Aug)

*Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto M, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, Mimura M, Tanaka KF, Miyakawa T, Iwatsubo T, Hata JI, Niikura T, *Yasui M. Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model. Acta Neuropathologica Communications 8(1)67. doi: 10.1186/s40478-020-00936-3. (2020 May)

Wenderski W, Wang L, Krokhotin A, Walsh JJ, Li H, Shoji H, Ghosh S, George RD, Miller EL, Elias L, Gillespie MA, Son EY, Staahl BT, Baek ST, Stanley V, Moncada C, Shipony Z, Linker SB, Marchetto MCN, Gage FH, Chen D, Sultan T, Zaki MS, Ranish JA, Miyakawa T, Luo L, Malenka RC, *Crabtree GR, *Gleeson JG. Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism. Proceedings of the National Academy of Sciences of the United States of America 117(18)10055-10066. doi: 10.1073/pnas.1908238117. (2020 Apr)

Nakagawa T, Hattori S, Nobuta R, Kimura R, Nakagawa M, Matsumoto M, Nagasawa Y, Funayama R, Miyakawa T, Inada T, Osumi N, Nakayama KI, *Nakayama K. The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression. iScience 23(4)101030. doi: 10.1016/j.isci.2020.101030. (2020 Apr)

Sala G, Chakraborti R, Ota A, *Miyakawa T. Association of BCG vaccination policy with prevalence and mortality of COVID-19. medRxiv Preprint. doi.org/10.1101/2020.03.30.20048165. (2020 Apr)

Takeuchi H, Imamura K, Ji B, Tsukita K, Enami T, Takao K, Miyakawa T, Hasegawa M, Sahara N, Iwata N, Inoue M, Hara H, Tabira T, Ono M, Trojanowski JQ, Lee VM, Takahashi R, Suhara T, Higuchi M, Inoue H. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ Vaccines 5:28. doi: 10.1038/s41541-020-0172-y. (2020 Mar)

Kawamura A, Katayama Y, *Nishiyama M, Shoji H, Tokuoka K, Ueta Y, Miyata M, Isa T, Miyakawa T, Hayashi-Takagi A, Nakayama KI. Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice. Human Molecular Genetics 29(8)1274-1291. doi.org/10.1093/hmg/ddaa036. (2020 Mar)

*Miwa T, Ohta K, Ito N, Hattori S, Miyakawa T, Takeo T, Nakagata N, Song WJ, Minoda R. Tsukushi is essential for the development of the inner ear. Molecular Brain 13(1)29. doi.org/10.1186/s13041-020-00570-z. (2020 Mar)

*Miyakawa T. No raw data, no science: another possible source of the reproducibility crisis. Molecular Brain 13(1)24. doi: 10.1186/s13041-020-0552-2. (2020 Feb)

Isokawa M, *Sassa T, Hattori S, Miyakawa T, Kihara A. Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1. FASEB BioAdvances1(12)747-759. doi.org/10.1096/fba.2019-00067. (2019 Nov)

Shoji H, *Miyakawa T. Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice. Neuropsychopharmacology Reports 40(1)73-84. doi: 10.1002/npr2.12093. (2019 Dec)

Hagihara H, Murano T, Ohira K, Miwa M, Nakamura K, *Miyakawa T. Expression of progenitor cell/immature neuron markers does not present definitive evidence for adult neurogenesis. Molecular Brain 12(1)108. doi: 10.1186/s13041-019-0522-8. (2019 Dec)

Hagihara H, Horikawa T, Irino Y, Nakamura HK, Umemori J, Shoji H, Yoshida M, Kamitani Y, *Miyakawa T. Peripheral blood metabolome predicts mood change-related activity in mouse model of bipolar disorder. Molecular Brain 12(1)107. doi: 10.1186/s13041-019-0527-3. (2019 Dec)

Shoji H, *Miyakawa T. Increased depression-related behavior during the postpartum period in inbred BALB/c and C57BL/6 strains. Molecular Brain 12(1)70. doi: 10.1186/s13041-019-0490-z. (2019 Aug)

Ohira K, Hagihara H, Miwa M, Nakamura K, *Miyakawa T. Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset. Molecular Brain 12(1)69. doi: 10.1186/s13041-019-0489-5. (2019 Aug)

Nakajima R, Takao K, Hattori S, Shoji H, Komiyama NH, Grant SGN, *Miyakawa T. Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice. Neuropsychopharmacology Reports 39(3)223-237. doi: 10.1002/npr2.12073. (2019 July)

Ono CT, Yu Z, Kikuchi Y, Kunii Y, Hino M, Matsumoto J, Nagaoka A, Ito J, Iwasaki Y, Hagihara H, Miyakawa T, Yoshida M, Saito Y, Niwa SI, Yabe H, Kakita A, *Tomita H. A minimal amount of tissue-based pH measurement to improve quality control in neuropsychiatric postmortem brain studies. Psychiatry and Clinical Neurosciences 73(9)566-573. doi: 10.1111/pcn.12863. (2019 May)

Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T, Montal M, *Yamakawa K. Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity. Molecular Autism 10:15. doi: 10.1186/s13229-019-0265-5. (2019 Mar)

Shoji H, *Miyakawa T. Age-related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program. Neuropsychopharmacol Reports 39(2)100-118. doi: 10.1002/npr2.12052. (2019 Feb)

Hagihara H, Ohira K, *Miyakawa T. Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex. Neuropsychopharmacol Reports 39(2)78-89. doi: 10.1002/npr2.12048. (2019 Feb)

Koshimizu H, Nogawa S, Asano S, Ikeda M, Iwata N, Takahashi S, *Saito K, *Miyakawa T. Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population. Translational Psychiatry 9(1)52. doi: 10.1038/s41398-019-0383-z. (2019 Jan)

Murano T, Hagihara H, Tajinda K, Matsumoto M, *Miyakawa T. Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders. Communications Biology 2;32. doi.org/10.1038/s42003-018-0277-2. (2019 Jan)

Hattori S, Okumura Y, Takao K, Yamaguchi Y, *Miyakawa T. Open source code for behavior analysis in rodents.s. Neuropsychopharmacology Reports 39(1)67-69. doi: 10.1002/npr2.12047. (2019 Jan)

*Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Mito T, Matsumoto H, Miyakawa T, Nakada K. Acquired expression of mutant Mitofusin 2 causes progressive neurodegeneration and abnormal behavior. Journal of Neuroscience 39(9)1588-1604. doi: 10.1523/JNEUROSCI.2139-18.2018. (2019 Jan)

Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Oh YS, Jang JH, Shin CH, Ohnishi YN, Hanada Y, Miyakawa T, Kim Y, Greengard P, *Nishi A. Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine. Molecular Psychiatry. 25(6)1229-1244. doi: 10.1038/s41380-018-0316-x. (2018 Dec Epub ahead of print) (2020)

Koshimizu H, Hirata N, Takao K, Toyama K, Ichinose T, Furuya S, *Miyakawa T. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacology Reports39(1)56-60. doi: 10.1002/npr2.12041. (2018 Nov Epub ahead of print) (2019)

*Katano T, Takao K, Abe M, Yamazaki M, Watanabe M, Miyakawa T, Sakimura K, Ito S. Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery. Molecular Brain11(1)63. doi.org/10.1186/s13041-018-0407-2. (2018 Oct)

Global Neuroethics Summit Delegates, Rommelfanger KS, Jeong SJ, Ema A, Fukushi T, Kasai K, Ramos KM, Salles A, Singh I. Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives. Neuron 100(1)19-36. doi: 10.1016/j.neuron.2018.09.021. (2018 Oct)

Kobayashi K, Takagi T, Ishii S, Suzuki H, Miyakawa T. Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia. Molecular Brain 11(1)56. doi: 10.1186/s13041-018-0400-9. (2018 Oct)

Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, *Shirakawa H, Kaneko S. TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Research 1704:68-77. doi: 10.1016/j.brainres.2018.09.031. (Epub ahead 2018 Sep) (2019 Jan)

Hirata N, Hattori S, Shoji H, Funakoshi H, *Miyakawa T. Comprehensive behavioral analysis of indoleamine 2,3-dioxygenase knockout mice. Neuropsychopharmacology Reports 38(3)133-144. doi: 10.1002/npr2.12019. (2018 Sep)

Kanetake T, *Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, *Kihara A. Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide. FASEB JOURNAL 33(1)928-941. doi: 10.1096/fj.201800291R. (2018 Aug Epub ahead) (2019)

Shoji H, *Miyakawa T. Relationships between the acoustic startle response and prepulse inhibition in C57BL/6J mice: a large-scale meta-analytic study. Molecular Brain 11(1)42. doi: 10.1186/s13041-018-0382-7. (2018 Jul)

Hagihara H, Fujita M, Umemori J, Hashimoto M, *Miyakawa T. Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein. Molecular Brain 11(1)38. doi: 10.1186/s13041-018-0378-3 (2018 Jul)

Inoue R, Talukdar G, Takao K, Miyakawa T, *Mori H. Dissociated role of D-serine in extinction during consolidation vs. reconsolidation of context conditioned fear. Frontiers in Molecular Neuroscience 11:161. doi: 10.3389/fnmol.2018.00161 (2018 May)

Maeta K, Hattori S, Ikutomo J, Edamatsu H, Bilasy SE, Miyakawa T, *Kataoka T. Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain. Molecular Brain 11(1)27. doi: 10.1186/s13041-018-0370-y. (2018 May)

Okuda K, Takao K, Watanabe A, Miyakawa T, Mizuguchi M, *Tanaka T. Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. PLoS One. 13(4):e0196587. doi: 10.1371/journal.pone.0196587. (2018 Apr)

Hattori S, Takao K, Funakoshi H, *Miyakawa T. Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2) knockout mice. Neuropsychopharmacology Reports 38(2)52-60. doi: 10.1002/npr2.12006. (2018 Mar)

Hagihara H, Catts VS, Katayama Y, Shoji H, Takagi T, Huang FL, Nakao A, Mori Y, Huang KP, Ishii S, Graef IA, Nakayama KI, Shannon Weickert C, *Miyakawa T. Decreased brain pH as a shared endophenotype of psychiatric disorders. Neuropsychopharmacology 43, 459–468. doi: 10.1038/npp.2017.167. (2018 Feb)

Shoji H, Irino Y, Yoshida M, *Miyakawa T. Behavioral effects of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice. Neuropsychopharmacology Reports 38(1)18-36. doi: 10.1002/npr2.12002. (2018 Jan)

Nakao A, Miyazaki N, Ohira K, Hagihara H, Takagi T, Usuda N, Ishii S, Murata K, *Miyakawa T. Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability. Molecular Brain 10(1)60. doi: 10.1186/s13041-017-0339-2. (2017 Dec)

Yoshioka N, Miyata S, Tamada A, Watanabe Y, Kawasaki A, Kitagawa H, Takao K, Miyakawa T, Takeuchi K, *Igarashi M. Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis. Molecular Brain 10(1)47. doi: 10.1186/s13041-017-0328-5. (2017 Oct)

Shibutani M, Horii T, Shoji H, Morita S, Kimura M, Terawaki N, Miyakawa T, *Hatada I. Arid1b haploinsufficiency causes abnormal brain gene expression and autism-related behaviors in mice. International Journal of Molecular Sciences 18(9)1872. doi:10.3390/ijms18091872. (2017 Aug)

Umeda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, *Tomiyama T. Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice. Acta Neuropathologica Communications 5(1)59. doi: 10.1186/s40478-017-0461-5. (2017 Jul)

*Umemura M, Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y. Comprehensive behavioral analysis of activating transcription factor 5-deficient mice. Frontiers in Behavioral Neuroscience 11:125. doi: 10.3389/fnbeh.2017.00125. (2017 Jul)

*Hayashi S, Inoue Y, Hattori S, Kaneko M, Shioi G, Miyakawa T, *Takeichi M. Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice. Scientific Reports 7(1)5801. doi: 10.1038/s41598-017-06374-x. (2017 Jul)

Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, *Hashimoto H, Shirahige K, *Yamashita T. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. Journal of Experimental Medicine 214(5)1431-1452. doi: 10.1084/jem.20161517. (2017 May)

Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, *Yamakawa K. Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. Experimental Neurology 293:1-12. doi: 10.1016/j.expneurol.2017.03.009. (2017 Jul)

Murano T, Koshimizu H, Hagihara H, *Miyakawa T. Transcriptomic immaturity of the hippocampus and prefrontal cortex in patients with alcoholism. Scientific Reports 7:44531. doi: 10.1038/srep44531. (2017 Mar)

*Ueda H, Sasaki K, Halder SK, Dequchi Y, Takao K, Miyakawa T, Tajima A. Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis. Journal of Neurochemistry 141:124–136. doi: 10.1111/jnc.13963. (2017 Apr)

Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, *Sakurai T. QRFP-Deficient Mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior. PLoS One 11(11)e0164716. doi: 10.1371/journal.pone.0164716.(2016 Nov)

Hagihara H, Shoji H, *Miyakawa T. Immaturity of brain as an endophenotype of neuropsychiatric disorders. Nihon Yakurigaku Zasshi 148(4)168-175, doi: 10.1254/fpj.148.168 (2016 Oct)

Morishita Y, *Yoshioka Y, Takimura Y, Shimizu Y, Namba Y, Nojiri N, Ishizaka T, Takao K, Yamashita F, Takuma K, Ago Y, Nagano K, Mukai Y, Kamada H, Tsunoda S, Saito S, Matsuda T, Hashida M, Miyakawa T, Higashisaka K, *Tsutsumi Y. Distribution of silver nanoparticles to breast milk and their biological effects on breast-fed offspring mice. ACS Nano 10(9)8180-91, doi: 10.1021/acsnano.6b01782. (2016 Aug)

Katayama Y, *Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama K.I. CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Nature 537:675–679, doi:10.1038/nature19357. (2016 Sep)

Sakai K, Shoji H, Kohno T, Miyakawa T, *Hattori M. Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders. Scientific Reports 6:28636, doi:10.1038/srep28636 (2016 Jun)

Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, *Nakagawa S. Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Scientific Reports 6:27204, doi: 10.1038/srep27204 (2016 Jun)

Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, *Kihara A. Disruption of the Sjögren-Larsson syndrome gene Aldh3a2 in mice increases Keratinocyte growth and retards skin barrier recovery. Journal of Biological Chemistry 291(22)1676-88, doi 10.1074/jbc.M116.714030 (2016 May)

Takao K, Shoji H, Hattori S, *Miyakawa T. Cohort removal induces changes in body temperature, pain sensitivity, and anxiety-like behavior. Frontiers in Behavioral Neuroscience 10:99. doi: 10.3389/fnbeh.2016.00099. (2016 Jun)

Hagihara H, Horikawa T, Nakamura HK, Umemori J, Shoji H, Kamitani Y, *Miyakawa T. Circadian gene circuitry predicts hyperactive behavior in a mood disorder mouse model. Cell Reports 14(12) 2784-96. doi: 10.1016/j.celrep.2016.02.067 (2016 Mar)

Ohashi R, Takao K, Miyakawa T, *Shiina N. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Scientific Reports 6, 20775. doi: 10.1038/srep20775 (2016 Feb)

*Matsuda I, Shoji H, Yamasaki N, Miyakawa T, Aiba A. Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse. Molecular Brain 9(1)15, doi: 10.1186/s13041-016-0196-4 (2016 Feb)

Shoji H, Takao K, Hattori S, *Miyakawa T. Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age. Molecular Brain 9(1)11. doi: 10.1186/s13041-016-0191-9 (2016 Jan)

*Imai H, Shoji H, Ogata M, Kagawa Y, Owada Y, Miyakawa T, Sakimura K, Terashima T, Katsuyama Y. Dorsal forebrain-specific deficiency of Reelin-Dab1 signal causes behavioral abnormalities related to psychiatric disorders. Cerebral Cortex 27(7)3485-3501. doi: 10.1093/cercor/bhv334. (2016 Jan)