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2019年

Shoji H, *Miyakawa T. Increased depression-related behavior during the postpartum period in inbred BALB/c and C57BL/6 strains. Molecular Brain 12(1):70. doi: 10.1186/s13041-019-0490-z. (2019 Aug)

Ohira K, Hagihara H, Miwa M, Nakamura K, *Miyakawa T. Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset. Molecular Brain 12(1):69. doi: 10.1186/s13041-019-0489-5. (2019 Aug)

Nakajima R, Takao K, Hattori S, Shoji H, Komiyama NH, Grant SGN, *Miyakawa T. Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice. Neuropsychopharmacology Reports. [Epub ahead of print] doi: 10.1002/npr2.12073. (2019 July)

Ono CT, Yu Z, Kikuchi Y, Kunii Y, Hino M, Matsumoto J, Nagaoka A, Ito J, Iwasaki Y, Hagihara H, Miyakawa T, Yoshida M, Saito Y, Niwa SI, Yabe H, Kakita A, *Tomita H. A minimal amount of tissue-based pH measurement to improve quality control in neuropsychiatric postmortem brain studies. Psychiatry and Clinical Neurosciences [Epub ahead of print] doi: 10.1111/pcn.12863. (2019 May)

Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T, Montal M, *Yamakawa K. Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity. Molecular Autism 10:15. doi: 10.1186/s13229-019-0265-5. (2019 Mar)

Shoji H, *Miyakawa T. Age-related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program. Neuropsychopharmacol Reports [Epub ahead of print] doi: 10.1002/npr2.12052. (2019 Feb)

Hagihara H, Ohira K, *Miyakawa T. Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex. Neuropsychopharmacol Reports [Epub ahead of print]. doi: 10.1002/npr2.12048. (2019 Feb)

Koshimizu H, Nogawa S, Asano S, Ikeda M, Iwata N, Takahashi S, *Saito K, *Miyakawa T. Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population. Translational Psychiatry 9(1):52. doi: 10.1038/s41398-019-0383-z. (2019 Jan)

Murano T, Hagihara H, Tajinda K, Matsumoto M, *Miyakawa T. Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders. Communications Biology 2; 32. doi.org/10.1038/s42003-018-0277-2. (2019 Jan)

Hattori S, Okumura Y, Takao K, Yamaguchi Y, *Miyakawa T. Open source code for behavior analysis in rodents.s. Neuropsychopharmacology Reports 39(1) 67-69. [Epub ahead of print] doi: 10.1002/npr2.12047. (2019 Jan)

*Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Mito T, Matsumoto H, Miyakawa T, Nakada K. Acquired expression of mutant Mitofusin 2 causes progressive neurodegeneration and abnormal behavior. Journal of Neuroscience 39 (9) 1588-1604 [Epub ahead of print] doi: 10.1523/JNEUROSCI.2139-18.2018. (2019 Jan)

2018年

Shuto T, Kuroiwa M, Sotogaku N, Kawahara Y, Oh YS, Jang JH, Shin CH, Ohnishi YN, Hanada Y, Miyakawa T, Kim Y, Greengard P, *Nishi A. Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine. Molecular Psychiatry. [Epub ahead of print] doi: 10.1038/s41380-018-0316-x. (2018 Dec)

Koshimizu H, Hirata N, Takao K, Toyama K, Ichinose T, Furuya S, *Miyakawa T. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacology Reports. [Epub ahead of print] doi: 10.1002/npr2.12041. (2018 Nov)

*Katano T, Takao K, Abe M, Yamazaki M, Watanabe M, Miyakawa T, Sakimura K, Ito S. Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery. Molecular Brain.11(1):63. doi.org/10.1186/s13041-018-0407-2. (2018 Oct)

Global Neuroethics Summit Delegates, Rommelfanger KS, Jeong SJ, Ema A, Fukushi T, Kasai K, Ramos KM, Salles A, Singh I. Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives. Neuron. 100(1):19-36. doi: 10.1016/j.neuron.2018.09.021. (2018 Oct)

Kobayashi K, Takagi T, Ishii S, Suzuki H, Miyakawa T. Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia. Molecular Brain. 11(1):56. doi: 10.1186/s13041-018-0400-9. (2018 Oct)

Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, *Shirakawa H, Kaneko S. TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Research. pii: S0006-8993(18)30496-7. 1704:68-77. doi: 10.1016/j.brainres.2018.09.031. (2019 Jan) (Epub ahead 2018 Sep)

Hirata N, Hattori S, Shoji H, Funakoshi H, *Miyakawa T. Comprehensive behavioral analysis of indoleamine 2,3-dioxygenase knockout mice. Neuropsychopharmacology Reports. 38(3):133-144. doi: 10.1002/npr2.12019. (2018 Sep)

Kanetake T, *Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, *Kihara A. Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide. FASEB JOURNAL. 7:fj201800291R. doi: 10.1096/fj.201800291R. (2018 Aug)

Shoji H, *Miyakawa T. Relationships between the acoustic startle response and prepulse inhibition in C57BL/6J mice: a large-scale meta-analytic study. Molecular Brain. 11(1):42. doi: 10.1186/s13041-018-0382-7. (2018 Jul)

Hagihara H, Fujita M, Umemori J, Hashimoto M, *Miyakawa T. Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein. Molecular Brain. 11(1):38. doi: 10.1186/s13041-018-0378-3 (2018 Jul)

Inoue R, Talukdar G, Takao K, Miyakawa T, *Mori H. Dissociated role of D-serine in extinction during consolidation vs. reconsolidation of context conditioned fear. Frontiers in Molecular Neuroscience. 11:161. doi: 10.3389/fnmol.2018.00161 (2018 May)

Maeta K, Hattori S, Ikutomo J, Edamatsu H, Bilasy SE, Miyakawa T, *Kataoka T. Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain. Molecular Brain. 11(1):27. doi: 10.1186/s13041-018-0370-y. (2018 May)

Okuda K, Takao K, Watanabe A, Miyakawa T, Mizuguchi M, *Tanaka T. Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. PLoS One. 13(4):e0196587. doi: 10.1371/journal.pone.0196587. (2018 Apr)

Hattori S, Takao K, Funakoshi H, *Miyakawa T. Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2) knockout mice. Neuropsychopharmacology Reports. doi: 10.1002/npr2.12006. (2018 Mar)

Hagihara H, Catts VS, Katayama Y, Shoji H, Takagi T, Huang FL, Nakao A, Mori Y, Huang KP, Ishii S, Graef IA, Nakayama KI, Shannon Weickert C, *Miyakawa T. Decreased brain pH as a shared endophenotype of psychiatric disorders. Neuropsychopharmacology. 43, 459–468. doi: 10.1038/npp.2017.167. (2018 Feb)

Shoji H, Irino Y, Yoshida M, *Miyakawa T. Behavioral effects of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice. Neuropsychopharmacology Reports. doi: 10.1002/npr2.12002. (2018 Jan)

2017年

Nakao A, Miyazaki N, Ohira K, Hagihara H, Takagi T, Usuda N, Ishii S, Murata K, *Miyakawa T. Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability. Molecular Brain. 10(1):60. doi: 10.1186/s13041-017-0339-2. (2017 Dec)

Yoshioka N, Miyata S, Tamada A, Watanabe Y, Kawasaki A, Kitagawa H, Takao K, Miyakawa T, Takeuchi K, *Igarashi M. Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis. Molecular Brain. 10(1):47. doi: 10.1186/s13041-017-0328-5. (2017 Oct)

Shibutani M, Horii T, Shoji H, Morita S, Kimura M, Terawaki N, Miyakawa T, *Hatada I. Arid1b haploinsufficiency causes abnormal brain gene expression and autism-related behaviors in mice. International Journal of Molecular Sciences. 18(9), 1872. doi:10.3390/ijms18091872. (2017 Aug)

Umeda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, *Tomiyama T. Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice. Acta Neuropathologica Communications. 5(1):59. doi: 10.1186/s40478-017-0461-5. (2017 Jul)

*Umemura M, Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y. Comprehensive behavioral analysis of activating transcription factor 5-deficient mice. Frontiers in Behavioral Neuroscience. 11:125. doi: 10.3389/fnbeh.2017.00125. (2017 Jul)

*Hayashi S, Inoue Y, Hattori S, Kaneko M, Shioi G, Miyakawa T, *Takeichi M. Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice. Scientific Reports. 7(1):5801. doi: 10.1038/s41598-017-06374-x. (2017 Jul)

Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, *Hashimoto H, Shirahige K, *Yamashita T. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. Journal of Experimental Medicine. 214(5):1431-1452. doi: 10.1084/jem.20161517. (2017 May)

Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, *Yamakawa K. Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. Experimental Neurology. 293:1-12. doi: 10.1016/j.expneurol.2017.03.009. (2017 Jul.)

Murano T, Koshimizu H, Hagihara H, *Miyakawa T. Transcriptomic immaturity of the hippocampus and prefrontal cortex in patients with alcoholism. Scientific Reports. 7:44531. doi: 10.1038/srep44531. (2017 Mar.)

*Ueda H, Sasaki K, Halder SK, Dequchi Y, Takao K, Miyakawa T, Tajima A. Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis. Journal of Neurochemistry 141: 124–136. doi: 10.1111/jnc.13963. (2017 Apr.)

2016年

Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, *Sakurai T. QRFP-Deficient Mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior. PLoS One 11(11):e0164716, doi: 10.1371/journal.pone.0164716.(2016 Nov.)

Hagihara H, Shoji H, *Miyakawa T. Immaturity of brain as an endophenotype of neuropsychiatric disorders. Nihon Yakurigaku Zasshi 148(4):168-175, doi: 10.1254/fpj.148.168 (2016 Oct.)

Morishita Y, *Yoshioka Y, Takimura Y, Shimizu Y, Namba Y, Nojiri N, Ishizaka T, Takao K, Yamashita F, Takuma K, Ago Y, Nagano K, Mukai Y, Kamada H, Tsunoda S, Saito S, Matsuda T, Hashida M, Miyakawa T, Higashisaka K, *Tsutsumi Y. Distribution of silver nanoparticles to breast milk and their biological effects on breast-fed offspring mice. ACS Nano 10(9):8180-91, doi: 10.1021/acsnano.6b01782. (2016 Aug.)

Katayama Y, *Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama K.I. CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Nature 537: 675–679, doi:10.1038/nature19357, (2016 Sep.)

Sakai K, Shoji H, Kohno T, Miyakawa T, *Hattori M. Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders. Scientific Reports 6: 28636, doi:10.1038/srep28636 (2016 Jun.)

Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, *Nakagawa S. Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Scientific Reports 6:27204, doi: 10.1038/srep27204 (2016 Jun)

Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, *Kihara A. Disruption of the Sjögren-Larsson syndrome gene Aldh3a2 in mice increases Keratinocyte growth and retards skin barrier recovery. Journal of Biological Chemistry 291(22):1676-88, doi 10.1074/jbc.M116.714030 (2016 May)

Takao K, Shoji H, Hattori S, *Miyakawa T. Cohort removal induces changes in body temperature, pain sensitivity, and anxiety-like behavior. Frontiers in Behavioral Neuroscience, 10:99, doi: 10.3389/fnbeh.2016.00099, (2016 Jun.)

Hagihara H, Horikawa T, Nakamura HK, Umemori J, Shoji H, Kamitani Y, *Miyakawa T. Circadian gene circuitry predicts hyperactive behavior in a mood disorder mouse model. Cell Reports 14(12), 2784-96, doi: 10.1016/j.celrep.2016.02.067 (2016 Mar.)

Ohashi R, Takao K, Miyakawa T, *Shiina N. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Scientific Reports 6, 20775, doi: 10.1038/srep20775 (2016 Feb.)

*Matsuda I, Shoji H, Yamasaki N, Miyakawa T, Aiba A. Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse. Molecular Brain 9(1), 15, doi: 10.1186/s13041-016-0196-4 (2016 Feb.)

Shoji H, Takao K, Hattori S, *Miyakawa T. Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age. Molecular Brain 9(1), 11, doi: 10.1186/s13041-016-0191-9 (2016 Jan.)

*Imai H, Shoji H, Ogata M, Kagawa Y, Owada Y, Miyakawa T, Sakimura K, Terashima T, Katsuyama Y. Dorsal forebrain-specific deficiency of Reelin-Dab1 signal causes behavioral abnormalities related to psychiatric disorders. Cerebral Cortex pii: bhv334, doi: 10.1093/cercor/bhv334. (2016 Jan.)

2015年

Abbas MG, Shoji H, Soya S, Hondo M, Miyakawa T, *Sakurai T. Comprehensive behavioral analysis of male Ox1r (-/-) mice showed implication of Orexin Receptor-1 in mood, anxiety, and social behavior. Frontiers Behavioral Neuroscience 9, 324, doi: 10.3389/fnbeh.2015.00324. (2015 Dec.)

Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, *Kinoshita M. A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Nature Communications 6, 10090, doi:10.1038/ncomms10090. (2015 Dec.)

Choi JK, Zhu A, Jenkins BG, Hattori S, Kil KE, Takagi T, Ishii S, Miyakawa T, *Brownell AL. Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice. Neuroscience Letter 609, 159-164, doi: 10.1016/j.neulet.2015.10.037. (2015 Nov.)

*Shibasaki K, Sugio S, Takao K, Yamanaka A, Miyakawa T, Tominaga M, Ishizaki Y. TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior. Pflugers Archiv 467(12), 2495-2507, doi: 10.1007/s00424-015-1726-0. (2015 Dec.)

Nakao A, Miki T, Shoji H, Nishi M, Takeshita H, *Miyakawa T, *Mori Y. Comprehensive behavioral analysis of voltage-gated calcium channel beta anchoring and -regulatory protein knockout mice. Frontiers Behavioral Neuroscience 9, 141, doi: 10.3389/fnbeh.2015.00141. (2015 Jun.)

Kawaai K, Mizutani A, Shoji H, Ogawa N, Ebisui E, Kuroda Y, Wakana S, Miyakawa T, Hisatsune C, *Mikoshiba K. IRBIT regulates CaMKIIa activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 112(17), 5512-5520, doi: 10.1073/pnas.1503310112. (2015 Apr.)

Takao K, Hagihara H, *Miyakawa T. Reply to Warren et al. and Shay et al.: Commonalities across species do exist and are potentially important. Proceedings of the National Academy of Sciences of the United States of America 112(4), E347-348, doi: 10.1073/pnas.1417369111. (2015 Jan.)

Takao K, *Miyakawa T. Genomic responses in mouse models greatly mimic human inflammatory diseases. Proceedings of the National Academy of Sciences of the United States of America 112(4), 1167-1172, doi: 10.1073/pnas.1401965111. (2015 Jan.)

〜2014年