Case 141. Herpes simplex virus infection of vulva (28 y-o F)

       
 
Touch smear from painful vulvar ulceration
 
       

 

  Haloed intranuclear inclusion of Cowdry's type A is infrequently encountered. Immunostaining using anti-HSV antiserum demonstrates positive signals in both the nuclei and cytoplasm (left: Papanicolaou, right: immunostaining by re-staining method).