The moment of MR1 discovery is described. The MR1 gene is the first and the last reported human MHC-related gene intentionally isolated from the human genome composed of three billion base pairs. Evolutionary considerations formed the basis of its...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 443(2) 422-427 2014年1月 [査読有り]
The major histocompatibility complex (MHC) class I-related molecule, MR1, is highly conserved in mammals and can present bacteria-derived vitamin B metabolites to mucosal-associated invariant T (MAIT) cells, possibly having important defense funct...
Background: Classical major histocompatibility complex (MHC) class II molecules play an essential role in presenting peptide antigens to CD4§ssup§+§esup§ T lymphocytes in the acquired immune system. The non-classical class II DM molecule, HLA-DM i...
Kentaro Tsukamoto Janine E. Deakin Jennifer A. Marshall Graves Keiichiro Hashimoto
Immunogenetics 65(2) 115-124 2013年2月 [査読有り]
The major histocompatibility complex (MHC) class I-related gene, MR1, is a non-classical MHC class IA gene and is encoded outside the MHC region. The MR1 is responsible for activation of mucosal-associated invariant T (MAIT) cells expressing semi-...
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