Clioquinol has been implicated as a causative agent for subacute myelo-optico-neuropathy (SMON) in humans, although the mechanism remains to be elucidated. In this study, we utilized astrocyte-derived cell line, KT-5 cells to explore its potential...
Biochemical and biophysical research communications 536 73-79 2021年1月
Cerebrospinal fluid (CSF) contains glycosphingolipids, including lactosylceramide (LacCer, Galβ(1,4)Glcβ-ceramide). LacCer and its structural isomer, galabiosylceramide (Gb2, Galα(1,4)Galβ-ceramide), are classified as ceramide dihexosides (CDH). G...
Journal of Parkinson's disease 11(1) 221-232 2021年
BACKGROUND: As mutations in glucocerebrosidase 1 (GBA1) are a major risk factor for Parkinson's disease (PD), decreased GBA1 activity might play an important role in the pathogenesis of the disease. However, there are currently no reports on gluco...
Brain : a journal of neurology 143(4) 1190-1205 2020年4月
Recently, the genetic variability in lysosomal storage disorders has been implicated in the pathogenesis of Parkinson's disease. Here, we found that variants in prosaposin (PSAP), a rare causative gene of various types of lysosomal storage disorde...
Niimi Y   Ito S   Mizutani Y   Murate K   Shima S   Ueda A   Satake W   Hattori N   Toda T   Mutoh T   
Parkinsonism & related disorders 61 132-137 2019年4月 [査読有り]