CANCER CHEMOTHERAPY AND PHARMACOLOGY 73(4) 673-683 2014年4月
Purpose A phase 1 study of pazopanib alone or in combination with lapatinib was conducted to assess the safety, tolerability, and pharmacokinetics of these oral tyrosine kinase inhibitors in Japanese patients with solid tumors.
Methods In part A (...
NAGOYA JOURNAL OF MEDICAL SCIENCE 76(1-2) 173-180 2014年2月
We report a case of primary small cell carcinoma (SCC) of the breast in a 59-year-old female. To the best of our knowledge, there are only 44 cases of this disease reported in the English literature. The patient also had regional nodal metastases,...
Background: Corrected QT (QTc) interval prolongation can induce fatal arrhythmias such as torsade de pointes.
Patients and methods: To assess the characteristics of QTc intervals and arrhythmias in women with early breast cancer who received FEC10...
Objective: This pharmacokinetic study of S-1 was conducted in patients in whom glomerular filtration rate (GFR) was directly measured to explore the possibility of adjusting the S-1 dose on the basis of GFR in patients with normal or nearly normal...