研究者氏名	竹中政史

URL
所属	藤田医科大学
部署	医学部医学科腎泌尿器外科学
職名	助教
学位	博士(医学）
J-Global ID	201501004387732430

MISC

12 >

Anti-major histocompatibility complex-induced obliterative airway disease: Selective role for CD4 and CD8 T cells in inducing immune responses to self-antigens

Venkataswarup Tiriveedhi Masashi Takenaka Nayan J. Sarma Andrew G. Gelman Thalachallour Mohanakumar

JOURNAL OF HEART AND LUNG TRANSPLANTATION 32(7) 714-722 2013年7月

BACKGROUND: The goal of this study was to define the role of T-cell sub-sets in the pathogenesis of autoimmunity-induced obliterative airway disease by passive transfer of CD8+ or CD4+ T cells.
METHODS: Antibodies to major histocompatibility compl...

Critical Role for IL-17A/F in the Immunopathogenesis of Obliterative Airway Disease Induced by Anti-MHC I Antibodies

Haseeb Ilias Basha Sabarinathan Ramachandran Venkataswarup Tiriveedhi Masashi Takenaka Vijay Subramanian Dilip S. Nath Nicholas Benshoff G. Alec Patterson Thalachallour Mohanakumar

TRANSPLANTATION 95(2) 293-300 2013年1月

Background. The IL-17 axis is implicated in pathogenesis of chronic rejection after human lung transplantation. Using a murine model of obliterative airway disease (OAD), we recently demonstrated that Abs to MHC class I antigens can induce immune ...

Complement activation is not required for obliterative airway disease induced by antibodies to major histocompatibitity complex class I: Implications for chronic Lung rejection

Masashi Takenaka Vijay Subramanian Venkataswarup Tiriveedhi Donna Phelan Ramsey Hachem Elbert Trulock Andrew E. Gelman G. Alexander Patterson Kiyotaka Hoshinaga Thalachallour Mohanakumar

JOURNAL OF HEART AND LUNG TRANSPLANTATION 31(11) 1214-1222 2012年11月

BACKGROUND: The role of non-complement activating antibodies (ncAbs) to mismatched donor human leukocyte antigen (HLA) in the pathogenesis of chronic lung rejection is not known. We used a murine model of obliterative airway disease (OAD) induced ...

T Regulatory Cells Play a Significant Role in Modulating MHC Class I Antibody-Induced Obliterative Airway Disease

V. Tiriveedhi M. Takenaka S. Ramachandran A. E. Gelman V. Subramanian G. A. Patterson T. Mohanakumar

AMERICAN JOURNAL OF TRANSPLANTATION 12(10) 2663-2674 2012年10月

The molecular mechanisms leading to the development of chronic lung allograft dysfunction following de novo development of antibodies to mismatched donor MHC remain undefined. We demonstrated that intrabronchial administration of antibodies to MHC...

Antibodies to MHC Class II Molecules Induce Autoimmunity: Critical Role for Macrophages in the Immunopathogenesis of Obliterative Airway Disease

Masashi Takenaka Venkataswarup Tiriveedhi Vijay Subramanian Kiyotaka Hoshinaga Alexander G. Patterson Thalachallour Mohanakumar

PLOS ONE 7(8) e42370-e42370 2012年8月

Previous studies have shown that intrabronchial administration of antibodies (Abs) to MHC class I resulted in development of obliterative airway disease (OAD), a correlate of chronic human lung allograft rejection. Since development of Abs specifi...