Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implic...
The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission. Mice genetically deficient in 5-HTT expression have been used to study the physiological functions of 5-HTT in the brain and have been propos...
International journal of molecular sciences 24(6) 2023年3月 [査読有り]
Intense itching significantly reduces the quality of life, and atopic dermatitis is associated with psychiatric conditions, such as anxiety and depression. Psoriasis, another inflammatory skin disease, is often complicated by psychiatric symptoms,...
Although dyslipidemia in the brain has been implicated in neurodegenerative disorders, the molecular mechanisms underlying its pathogenesis have been largely unclear. PDZD8 is a lipid transfer protein and mice deficient in PDZD8 (PDZD8-KO mice) ma...
Hideo Hagihara   Hirotaka Shoji   Mahomi Kuroiwa   Isabella A Graef   Gerald R Crabtree   Akinori Nishi   Tsuyoshi Miyakawa   
Molecular brain 15(1) 94-94 2022年11月 [査読有り]
Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intellectual disability, autism spectrum di...
昌子浩孝   萩原英雄   高雄啓三   Noah M. WALTON   松本光之   宮川 剛   
基礎心理学研究 32(1) 101-119 2013年9月
Maturation and integration of neurons and grial cells in the hippocampus is considered to be essential for regulating endocrine, affective, and congnitive functions, and the disruption of such process may cause mental illness. Previously, we have ...