研究者氏名	西辻裕紀
	ニシツジヒロノリ
通称等の別名	藤田医科大学
URL
所属	藤田医科大学
部署	ウイルス学
職名	准教授
科研費研究者番号	20573661
J-Global ID	201801009029607414

研究分野

ライフサイエンス / ウイルス学 /

論文

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Pegylated interferon therapy-related microRNA-6126 downregulates sodium taurocholate cotransporting polypeptide expression in hepatocytes.

Koji Fujita Hironori Nishitsuji Hisakazu Iwama Tomoko Tadokoro Asahiro Morishita Shima Mimura Masafumi Ono Takashi Himoto Kunitada Shimotohno Tsutomu Masaki

Gene 853 147068-147068 2023年2月

Hepatitis B virus (HBV) infection is one of the most serious global health problems. Our previous data using an in vitro assay revealed that miR-6126 suppressed the extracellular HBs antigen level, suggesting that miR-6126 had potential to suppres...

N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx.

Takayuki Murata Satoko Iwahori Yusuke Okuno Hironori Nishitsuji Yusuke Yanagi Koichi Watashi Takaji Wakita Hiroshi Kimura Kunitada Shimotohno

International journal of molecular sciences 24(3) 2023年1月

N6-methyladenosine (m6A) is a post-transcriptional modification of RNA involved in transcript transport, degradation, translation, and splicing. We found that HBV RNA is modified by m6A predominantly in the coding region of HBx. The mutagenesis of...

Identification of neutralizing epitopes in the preS2 domain of the hepatitis B virus.

Keigo Yato Mami Matsuda Kento Fukano Tomohisa Tanaka Kohji Moriishi Hironori Nishitsuji Kunitada Shimotohno Koji Tamura Takaji Wakita Masamichi Muramatsu Takanobu Kato Ryosuke Suzuki

Virus research 323 199014-199014 2023年1月

Hepatitis B virus (HBV) infection is a major public health problem. The sodium taurocholate cotransporting polypeptide (NTCP) has been identified as an essential HBV receptor. Human hepatocytes are infected with HBV via binding between the preS1 r...

Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

Ayaka Washizaki Asako Murayama Megumi Murata Tomoko Kiyohara Keigo Yato Norie Yamada Hussein Hassan Aly Tomohisa Tanaka Kohji Moriishi Hironori Nishitsuji Kunitada Shimotohno Yasumasa Goh Ken J. Ishii Hiroshi Yotsuyanagi Masamichi Muramatsu Koji Ishii Yoshimasa Takahashi Ryosuke Suzuki Hirofumi Akari Takanobu Kato

Nature Communications 13(1) 2022年9月

Abstract

Although the current hepatitis B (HB) vaccine comprising small-HBs antigen (Ag) is potent and safe, attenuated prophylaxis against hepatitis B virus (HBV) with vaccine-escape mutations (VEMs) has been reported. We investigate an HB vacci...

Ubiquitination of SARS-CoV-2 NSP6 and ORF7a Facilitates NF-κB Activation.

Hironori Nishitsuji Satoko Iwahori Mariko Ohmori Kunitada Shimotohno Takayuki Murata

mBio e0097122 2022年7月

Patients with severe coronavirus disease 2019 tend to have high levels of proinflammatory cytokines, which eventually lead to cytokine storm and the development of acute respiratory distress syndrome. However, the detailed molecular mechanisms of ...