Tetrahydrobiopterin (BH4) is essential for the biosynthesis of dopamine, noradrenaline, and serotonin, which serve as cofactors for tyrosine hydroxylase (TH) and tryptophan hydroxylase. GTP cyclohydrolase (GCH) is the first and rate-limiting enzym...
Akira Ota Akira Nakashima Yoko S. Kaneko Keiji Mori Hiroshi Nagasaki Takeshi Takayanagi Mitsuyasu Itoh Kazunao Kondo Toshiharu Nagatsu Miyuki Ota
JOURNAL OF NEURAL TRANSMISSION 119(11) 1327-1342 2012年11月
Aripiprazole is the only atypical antipsychotic drug known to cause the phosphorylation of AMP-activated protein kinase (AMPK) in PC12 cells. However, the molecular mechanisms underlying this phosphorylation in aripiprazole-treated PC12 cells have...
JOURNAL OF BIOLOGICAL CHEMISTRY 286(2) 1445-1452 2011年1月
Postnatal development of dopaminergic system is closely related to the development of psychomotor function. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of dopamine and requires tetrahydrobiopterin (BH4) as a cofactor....
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18(4) 312-317 2011年
Aims: Cilostazol, a type. phosphodiesterase inhibitor, is utilized for the treatment of intermittent claudication and is considered to have the beneficial effects against the atherogenic process. In the present study, we examined the effects of ci...
JOURNAL OF PHARMACOLOGICAL SCIENCES 114(1) 17-24 2010年9月
5R-L-Erythro-5,6,7,8-tetrahydrobiopterin (BH(4)) is an essential cofactor for tyrosine hydroxylase (TH). Recently, a type of dopa-responsive dystonia (DRD) (DYT5, Segawa's disease) was revealed to be caused by dominant mutations of the gene e...
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