Takayuki Kannon Satoshi Murashige Tomoki Nishioka Mutsuki Amano Yasuhiro Funahashi Daisuke Tsuboi Yukie Yamahashi Taku Nagai Kozo Kaibuchi Junichiro Yoshimoto

Frontiers in Molecular Neuroscience 17 2024年4月

Protein phosphorylation, a key regulator of cellular processes, plays a central role in brain function and is implicated in neurological disorders. Information on protein phosphorylation is expected to be a clue for understanding various neuropsyc...

Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling

Daisuke Tsuboi Taku Nagai Junichiro Yoshimoto Kozo Kaibuchi

Frontiers in Molecular Neuroscience 17 2024年3月

The unraveling of the regulatory mechanisms that govern neuronal excitability is a major challenge for neuroscientists worldwide. Neurotransmitters play a critical role in maintaining the balance between excitatory and inhibitory activity in the b...

Neuroproteomic mapping of kinases and their substrates downstream of acetylcholine: finding and implications.

Yukie Yamahashi Daisuke Tsuboi Yasuhiro Funahashi Kozo Kaibuchi

Expert review of proteomics 2023年10月

INTRODUCTION: Since the emergence of the cholinergic hypothesis of Alzheimer's disease (AD), acetylcholine has been viewed as a mediator of learning and memory. Donepezil improves AD-associated learning deficits and memory loss by recovering brain...

Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance.

Xinjian Zhang Daisuke Tsuboi Yasuhiro Funahashi Yukie Yamahashi Kozo Kaibuchi Taku Nagai

International journal of molecular sciences 23(19) 2022年10月

Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the ventral tegmental area to the nucleus accumbens (NAc). Protein phosphorylatio...

Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior.

Daisuke Tsuboi Takeshi Otsuka Takushi Shimomura Md Omar Faruk Yukie Yamahashi Mutsuki Amano Yasuhiro Funahashi Keisuke Kuroda Tomoki Nishioka Kenta Kobayashi Hiromi Sano Taku Nagai Kiyofumi Yamada Anastasios V Tzingounis Atsushi Nambu Yoshihiro Kubo Yasuo Kawaguchi Kozo Kaibuchi

Cell reports 40(10) 111309-111309 2022年9月

Dysfunctional dopamine signaling is implicated in various neuropsychological disorders. Previously, we reported that dopamine increases D1 receptor (D1R)-expressing medium spiny neuron (MSN) excitability and firing rates in the nucleus accumbens (...

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Mechanism of dopamine signaling for membrane excitability

D. Tsuboi T. Shimomura T. Nakano T. Nagai M. Amano J. Yoshimoto Y. Kubo K. Kaibuchi

JOURNAL OF NEUROCHEMISTRY 142 135-135 2017年8月

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.

Taku Nagai Shinichi Nakamuta Keisuke Kuroda Sakura Nakauchi Tomoki Nishioka Tetsuya Takano Xinjian Zhang Daisuke Tsuboi Yasuhiro Funahashi Takashi Nakano Junichiro Yoshimoto Kenta Kobayashi Motokazu Uchigashima Masahiko Watanabe Masami Miura Akinori Nishi Kazuto Kobayashi Kiyofumi Yamada Mutsuki Amano Kozo Kaibuchi

Neuron 89(3) 550-65 2016年2月 [査読有り]

Dopamine (DA) type 1 receptor (D1R) signaling in the striatum presumably regulates neuronal excitability and reward-related behaviors through PKA. However, whether and how D1Rs and PKA regulate neuronal excitability and behavior remain largely unk...

注目の遺伝子(第31回)統合失調症発症脆弱性分子DISC1の研究から明らかになった課題と新機能

坪井大輔森大輔黒田啓介

分子精神医学 15(4) 301-303 2015年10月

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

Daisuke Ibi Taku Nagai Akira Nakajima Hiroyuki Mizoguchi Takahiro Kawase Daisuke Tsuboi Shin-Ichi Kano Yoshiaki Sato Masahiro Hayakawa Ulrike C. Lange David J. Adams M. Azim Surani Takaya Satoh Akira Sawa Kozo Kaibuchi Toshitaka Nabeshima Kiyofumi Yamada

GLIA 61(5) 679-693 2013年5月

Interferon-induced transmembrane protein 3 (IFITM3) plays a crucial role in the antiviral responses of Type I interferons (IFNs). The role of IFITM3 in the central nervous system (CNS) is, however, largely unknown, despite the fact that its expres...

精神疾患を分子生物学で考えてみる : 統合失調症発症脆弱性因子DISC1をモデルとして

貝淵弘三坪井大輔

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 30(3) 149-152 2010年6月