Although it has been suggested that the combination of exercise and bryostatin-1 administration may induce greater functional recovery than exercise alone, the detailed molecular mechanisms are not well known. Here, we examined the relationship be...
Daisuke Mori Hidekazu Miyake Kenmei Mizutani Kan Shimpo Shigeru Sonoda Toshiharu Yamamoto Shuu Fujiwara Kin-ya Kubo
ARCHIVES OF ORAL BIOLOGY 65 95-101 2016年5月 [査読有り]
Background and objective: Malocclusion induced by raising the bite causes chronic stress. Chronic stress leads to increased plasma corticosterone levels and impaired hippocampal function due to impaired neurogenesis or increased apoptosis in the h...
Hiroko Kondo Minori Kurahashi Daisuke Mori Mitsuo Iinuma Yasuo Tamura Kenmei Mizutani Kan Shimpo Shigeru Sonoda Kagaku Azuma Kin-ya Kubo
ARCHIVES OF ORAL BIOLOGY 61 1-7 2016年1月 [査読有り]
Background and objective: Teeth are crucial, not only for mastication, but for overall nutrition and general health, including cognitive function. Aged mice with chronic stress due to tooth loss exhibit impaired hippocampus-dependent learning and ...
Kenmei Mizutani Shigeru Sonoda Hideaki Wakita Kan Shimpo
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION 94(3) 239-243 2015年3月 [査読有り]
Recently, it has become widely known that neuronal reorganization in the perilesional cortex contributes to some improvement of hemiparesis after stroke. Here, the authors examined in vivo the effects of administration of bryostatin-1, an activato...
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 23(6) 1703-1708 2014年7月 [査読有り]
Predicting recovery from hemiparesis after stroke is important for rehabilitation. A few recent studies reported that the levels of some growth factors shortly after stroke were positively correlated with the clinical outcomes during the chronic p...
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