Ribosomal RNA (rRNA), the most abundant non-coding RNA species, is a major component of the ribosome. Impaired ribosome biogenesis causes the dysfunction of protein synthesis and diseases called "ribosomopathies," including genetic disorders with ...
The PET and LIM domain-containing protein, Prickle, plays a key role in planar cell polarity (PCP) in Drosophila. It has been reported that mutations in the PRICKLE2 gene, which encodes one of the human orthologues of Prickle, are associated with ...
Tadahiro Nagaoka   Masashi Kishi   
NEUROSCIENCE LETTERS 612 251-255 2016年1月 [査読有り]
The excitatory postsynaptic region of the vertebrate hippocampus is usually compartmentalized into the postsynaptic density (PSD) and N-cadherin-rich domain, which is important for synaptic adhesion. However, the molecular mechanisms underlying th...
Tadahiro Nagaoka   Katsuhiko Tabuchi   Masashi Kishi   
SCIENTIFIC REPORTS 5 12916 2015年8月 [査読有り]
Postsynaptic density-95/Discs large/Zonula occludens-1 (PDZ) domain-mediated protein interactions play pivotal roles in various molecular biological events, including protein localisation, assembly, and signal transduction. Although the vertebrate...
Nadia P. Castro   Natalie D. Fedorova-Abrams   Anand S. Merchant   Maria Cristina Rangel   Tadahiro Nagaoka   Hideaki Karasawa   Malgorzata Klauzinska   Stephen M. Hewitt   Kajal Biswas   Shyam K. Sharan   David S. Salomon   
ONCOTARGET 6(14) 11910-11929 2015年5月 [査読有り]
Triple-negative breast cancer (TNBC) presents the poorest prognosis among the breast cancer subtypes and no current standard therapy. Here, we performed an in-depth molecular analysis of a mouse model that establishes spontaneous lung metastasis f...