Ribosomal RNA (rRNA), the most abundant non-coding RNA species, is a major component of the ribosome. Impaired ribosome biogenesis causes the dysfunction of protein synthesis and diseases called "ribosomopathies," including genetic disorders with ...
Tadahiro Nagaoka Mikio Furuse Toshihisa Ohtsuka Kunihiro Tsuchida Masashi Kishi
Scientific reports 9(1) 2912-2912 2019年2月 [査読有り]
The PET and LIM domain-containing protein, Prickle, plays a key role in planar cell polarity (PCP) in Drosophila. It has been reported that mutations in the PRICKLE2 gene, which encodes one of the human orthologues of Prickle, are associated with ...
The excitatory postsynaptic region of the vertebrate hippocampus is usually compartmentalized into the postsynaptic density (PSD) and N-cadherin-rich domain, which is important for synaptic adhesion. However, the molecular mechanisms underlying th...
Postsynaptic density-95/Discs large/Zonula occludens-1 (PDZ) domain-mediated protein interactions play pivotal roles in various molecular biological events, including protein localisation, assembly, and signal transduction. Although the vertebrate...
Nadia P. Castro Natalie D. Fedorova-Abrams Anand S. Merchant Maria Cristina Rangel Tadahiro Nagaoka Hideaki Karasawa Malgorzata Klauzinska Stephen M. Hewitt Kajal Biswas Shyam K. Sharan David S. Salomon
ONCOTARGET 6(14) 11910-11929 2015年5月 [査読有り]
Triple-negative breast cancer (TNBC) presents the poorest prognosis among the breast cancer subtypes and no current standard therapy. Here, we performed an in-depth molecular analysis of a mouse model that establishes spontaneous lung metastasis f...
お知らせ・マニュアル
研究推進本部