Rei Yoshimoto Yuta Nakayama Ikuko Nomura Ikuko Yamamoto Yumeka Nakagawa Shigeyuki Tanaka Misuzu Kurihara Yu Suzuki Takehiko Kobayashi Hiroko Kozuka-Hata Masaaki Oyama Mari Mito Shintaro Iwasaki Tomohiro Yamazaki Tetsuro Hirose Kimi Araki Shinichi Nakagawa
Molecular Cell 2023年12月 [査読有り]
4.5SH RNA is a highly abundant, small rodent-specific noncoding RNA that localizes to nuclear speckles enriched in pre-mRNA-splicing regulators. To investigate the physiological functions of 4.5SH RNA, we have created mutant mice that lack the exp...
Kazuhiro Fukumura Luca Sperotto Stefanie Seuß Hyun-Seo Kang Rei Yoshimoto Michael Sattler Akila Mayeda
Cell reports 113534-113534 2023年12月 [査読有り]
Human pre-mRNA splicing requires the removal of introns with highly variable lengths, from tens to over a million nucleotides. Therefore, mechanisms of intron recognition and splicing are likely not universal. Recently, we reported that splicing i...
Histidine (His) residues are methylated in various proteins, but their roles and regulation mechanisms remain unknown. Here, we show that carnosine N-methyltransferase 1 (CARNMT1), a known His methyltransferase of dipeptide carnosine (βAla-His), i...
Short Interspersed Elements (SINEs) comprise a significant portion of the genomes of higher eukaryotes, including humans and mice. This review focuses on SINE-derived noncoding RNAs (ncRNAs), particularly BC1, BC200, and 4.5SH RNA, which are expre...
Rei Yoshimoto Fumiko Ishida Miyuki Yamaguchi Shigeyuki Tanaka
Frontiers in Fungal Biology 3 2022年8月 [査読有り]
The biogenesis of small non-coding RNAs is a molecular event that contributes to cellular functions. The basidiomycete fungus Ustilago maydis is a biotrophic pathogen parasitizing maize. A hallmark of its genome structure is an absence of RNAi mac...
A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.
Specialized enzymes add methyl groups to the nitrogens of the amino acid histidine, altering the chemical properties of its imidazole ring and, in turn, the function of the modified (poly)peptide. In this issue of Genes & Development, Shimazu and ...
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