Alina Iovleva   Christi L McElheny   Erin L Fowler   Eric Cober   Erica S Herc   Cesar A Arias   Carol Hill   Keri Baum   Vance G Fowler Jr   Henry F Chambers   Kerryl E Greenwood-Quaintance   Robin Patel   David van Duin   Robert A Bonomo   Yohei Doi   
Antimicrobial agents and chemotherapy 68(3) e0125823 2024年3月
The activity of a novel β-lactamase inhibitor combination, sulbactam-durlobactam (SUL-DUR), was tested against 87 colistin-resistant and/or cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii clinical isolates collected from U...
With the coronavirus disease 2019 (COVID-19) pandemic, there is growing interest in utilizing adaptive platform clinical trials (APTs), in which multiple drugs are compared with a single common control group, such as a placebo or standard-of-care ...
Anna Clara M Galdino   Mylene Vaillancourt   Diana Celedonio   Kara Huse   Yohei Doi   Janet S Lee   Peter Jorth   
Nature microbiology 9(3) 631-646 2024年3月
The antibiotic cefiderocol hijacks iron transporters to facilitate its uptake and resists β-lactamase degradation. While effective, resistance has been detected clinically with unknown mechanisms. Here, using experimental evolution, we identified ...
Leilei Wang   Xun Zhou   Yanyan Lu   Xuefei Zhang   Jianping Jiang   Zhewei Sun   Mengyun Yin   Yohei Doi   Minggui Wang   Qinglan Guo   Fan Yang   
International journal of antimicrobial agents 107119-107119 2024年2月
OBJECTIVE: Imipenem-relebactam (IMR), a novel β-lactam/β-lactamase inhibitor combination, is recommended for infections caused by difficult-to-treat Pseudomonas aeruginosa. This study aimed to investigate the evolution trajectory of IMR resistance...
Akito Kawai   William C Shropshire   Masahiro Suzuki   Jovan Borjan   Samuel L Aitken   William C Bachman   Christi L McElheny   Micah M Bhatti   Ryan K Shields   Samuel A Shelburne   Yohei Doi   
mBio 15(2) e0287423 2024年2月
β-Lactamases can accumulate stepwise mutations that increase their resistance profiles to the latest β-lactam agents. CMY-185 is a CMY-2-like β-lactamase and was identified in an Escherichia coli clinical strain isolated from a patient who underwe...