Journal of medicinal food 23(9) 967-977 2020年7月 [査読有り]
Mung bean (Vigna radiata) is an immunomodulatory medicinal plant, which is recognized as a component of a traditional postpartum diet. The liver plays a crucial role in fatty acid synthesis under the control of various hormones that are affected b...
Ghazala Mustafa   Murtaza Hasan   Hisateru Yamaguchi   Keisuke Hitachi   Kunihiro Tsuchida   Setsuko Komatsu   
Journal of proteomics 224 103833-103833 2020年7月 [査読有り]
Nanoparticles (NPs) are synthesized by different methods and response mechanism of plants varied towards NPs based on their origin. To study the effects of bio synthesized (BS) and chemically synthesized (CS) silver NPs on soybean, a gel-free/ lab...
International journal of molecular sciences 21(5) 2020年2月 [査読有り]
Skeletal muscle is a highly plastic organ that is necessary for homeostasis and health of the human body. The size of skeletal muscle changes in response to intrinsic and extrinsic stimuli. Although protein-coding RNAs including myostatin, NF-κβ, ...
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 39(6) 1297-1304 2020年2月 [査読有り]
Heterotopic ossification (HO) is a pathological condition in which ectopic bone forms within soft tissues such as skeletal muscle. Human platelet-derived growth factor receptor α positive (PDGFRα+) cells, which were proved to be the original cells...
Follistatin is well known as an inhibitor of transforming growth factor (TGF)-β superfamily ligands including myostatin and activin A. Myostatin, a negative regulator of muscle growth, is a promising target with which to treat muscle atrophic dise...
① 筋萎縮抑制薬開発。
② 多種類の筋萎縮誘導モデル、新規二分脊椎モデル。
③ ヒト正常筋や動物由来の高品質・高純度の筋幹細胞、筋支持細胞の取得技術
その細胞を用いた薬剤探索(筋の脂肪化抑制、骨化抑制)の応用実績。
④ 乳がん由来細胞を用いた、転移・接着性の分子機構解析(エクソソーム分泌、ホルモン感受性、接着分子制御など)。