Cellular and molecular life sciences : CMLS 76(24) 4829-4848 2019年12月 [査読有り]
Exosomes, a type of small extracellular vesicles (sEVs), are secreted membrane vesicles that are derived from various cell types, including cancer cells, mesenchymal stem cells, and immune cells via multivesicular bodies (MVBs). These sEVs contain...
Zhuoheng Zhong   Shengzhi Liu   Wei Zhu   Yuting Ou   Hisateru Yamaguchi   Keisuke Hitachi   Kunihiro Tsuchida   Jingkui Tian   Setsuko Komatsu   
Journal of proteome research 18(9) 3328-3341 2019年9月 [査読有り]
Ultraviolet (UV)-B radiation acts as an elicitor to enhance the production of secondary metabolites in medicinal plants. To investigate the mechanisms, which lead to secondary metabolites in Catharanthus roseus under UVB radiation, a phosphoproteo...
Myoparr is a promoter-associated long non-coding RNA (lncRNA) that is expressed from the promoter region of myogenin gene. Myoparr is essential for the proper differentiation of skeletal muscle cells; it accomplishes this by activating the express...
Skeletal muscle is a highly plastic tissue and decreased skeletal muscle mass (muscle atrophy) results in deteriorated motor function and perturbed body homeostasis. Myogenin promoter-associated long non-coding RNA (lncRNA) Myoparr promotes skelet...
① 筋萎縮抑制薬開発。
② 多種類の筋萎縮誘導モデル、新規二分脊椎モデル。
③ ヒト正常筋や動物由来の高品質・高純度の筋幹細胞、筋支持細胞の取得技術
その細胞を用いた薬剤探索(筋の脂肪化抑制、骨化抑制)の応用実績。
④ 乳がん由来細胞を用いた、転移・接着性の分子機構解析(エクソソーム分泌、ホルモン感受性、接着分子制御など)。