研究者氏名	黒澤仁
	クロサワジン
URL	http://kaken.nii.ac.jp/d/r/10410739.ja.html
所属	藤田医科大学
部署	その他部局等
職名
学位	理学博士(名古屋大学)
J-Global ID	201401018482788607

研究キーワード

腫瘍学 ,抗体

研究分野

ライフサイエンス / 腫瘍診断、治療学 /

論文

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Beneficial effects of 1,3-1,6 β-glucans produced by Aureobasidium pullulans on non-esterified fatty acid levels in diabetic KKAy mice and their potential implications in metabolic dysregulation.

Nobunao Ikewaki Yasunori Ikeue Mitsuru Nagataki Gene Kurosawa Vidyasagar Devaprasad Dedeepiya Mathaiyan Rajmohan Suryaprakash Vaddi Rajappa Senthilkumar Senthilkumar Preethy Samuel J K Abraham

Journal of diabetes and metabolic disorders 22(1) 487-494 2023年6月 [査読有り]

OBJECTIVES: In this study, we used an obese and diabetic mouse model to compare two strains of Aureobasidium pullulans (AFO-202 and N-163) produced beta-glucans (β-glucans), which alleviate lipotoxicity. METHODS: Four groups of KK-Ay mice were use...

Antibody dependent disease enhancement (ADE) after COVID-19 vaccination and beta glucans as a safer strategy in management.

Nobunao Ikewaki Gene Kurosawa Gary A Levy Senthilkumar Preethy Samuel J K Abraham

Vaccine 2023年3月 [査読有り]

A potential risk associated with vaccines for COVID-19 is antibody-dependent disease enhancement (ADE) in which vaccine induced antibody mediated immune responses may lead to enhanced SARS CoV- 2 acquisition or increased disease severity. Though A...

A Novel High-Throughput Screening Method for a Human Multicentric Osteosarcoma-Specific Antibody and Biomarker Using a Phage Display-Derived Monoclonal Antibody.

Takuma Hayashi Naoki Yamamoto Gene Kurosawa Kaori Tajima Mariko Kondo Noriko Hiramatsu Yu Kato Miho Tanaka Hisateru Yamaguchi Yoshikazu Kurosawa Harumoto Yamada Nobuyuki Fujita

Cancers 14(23) 2022年11月 [査読有り]

Osteosarcoma is a malignant tumor that produces neoplastic bone or osteoid osteoma. In human multicentric osteosarcoma (HMOS), a unique variant of human osteosarcoma (HOS), multiple bone lesions occur simultaneously or asynchronously before lung m...

Improvement of sleep and melatonin in children with autism spectrum disorder after β-1,3/1,6-glucan consumption: An open-label prospective pilot clinical study.

Kadalraja Raghavan Vidyasagar Devaprasad Dedeepiya Ramesh Shankar Kandaswamy Mangaleswaran Balamurugan Nobunao Ikewaki Tohru Sonoda Gene Kurosawa Masaru Iwasaki Senthilkumar Preethy Samuel Jk Abraham

Brain and behavior 12(9) e2750 2022年9月 [査読有り]

INTRODUCTION: Poor sleep quality is a major problem in patients with autism spectrum disorder (ASD), and is attributed to low melatonin levels. Melatonin supplementation is recommended; however, its effectiveness varies. β-Glucans have previously ...

Controlled modulation of all the arms of the immunity including innate immunity by biological response modifier glucans, a simple yet potential nutritional supplement strategy to fight COVID-19.

Nobunao Ikewaki Gene Kurosawa Tomohiko Kisaka Samuel J K Abraham

Journal of food biochemistry 46(7) e14156 2022年7月 [査読有り]

Immune modulation, being one of the potential strategies to combat COVID-19 infection, emphasis has been laid on enhancing the innate immune response in a balanced manner. Beta (β)-glucans have been suggested as nonspecific immunostimulatory adjuv...