Chizuru Akatsu Amin Alborzian Deh Sheikh Naoko Matsubara Hiromu Takematsu Astrid Schweizer Hajjaj H M Abdu-Allah Thomas F Tedder Lars Nitschke Hideharu Ishida Takeshi Tsubata
Science signaling 15(723) eabf9570 2022年3月
The protein tyrosine phosphatase CD45 plays a crucial role in B cell antigen receptor (BCR) signaling by activating Src family kinases. Cd45-/- mice show altered B cell development and a phenotype likely due to reduced steady-state signaling; howe...
Amin Alborzian Deh Sheikh Chizuru Akatsu Hajjaj H. M. Abdu-Allah Yuki Suganuma Akihiro Imamura Hiromune Ando Hiromu Takematsu Hideharu Ishida Takeshi Tsubata
The Journal of Immunology 206(11) 2544-2551 2021年6月 [査読有り]
CD22 is an inhibitory B cell coreceptor that regulates B cell development and activation by downregulating BCR signaling through activation of SH2-containing protein tyrosine phosphatase-1 (SHP-1). CD22 recognizes a2,6 sialic acid as a specific li...
Hiroki Doi Taei Matsui Johannes M Dijkstra Atsushi Ogasawara Yuki Higashimoto Seiji Imamura Tamae Ohye Hiromu Takematsu Itsuro Katsuda Hidehiko Akiyama
F1000Research 10 542-542 2021年
Background: Andrographolide (Andro) is a diterpenoid component of the plant Andrographis paniculata that is known for its anti-tumor activity against a variety of cancer cells. Methods: We studied the effects of Andro on the viability of the hum...
Alborzian Deh Sheikh A Gomaa S Li X Routledge M Saigoh K Numoto N Angata T Hitomi Y Takematsu H Tsuiji M Ito N Kusunoki S Tsubata T
J Autoimmun 116 102571-102571 2021年1月 [査読有り]
Guillain-Barré syndrome (GBS), including its variant Miller Fisher syndrome (MFS), is an acute peripheral neuropathy that involves autoimmune mechanisms leading to the production of autoantibodies to gangliosides; sialic acid-containing glycosphin...
Morise J Yamamoto S Midorikawa R Takamiya K Nonaka M Takematsu H Oka S
Int J Mol Sci. 21(14) 5101 2020年7月 [査読有り]
The AMPA-type glutamate receptor (AMPAR) is a homotetrameric or heterotetrameric ion channel composed of various combinations of four subunits (GluA1-4), and its abundance in the synapse determines the strength of synaptic activity. The formation ...
Cindy M. Spruit Nikoloz Nemanichvili Masatoshi Okamatsu Hiromu Takematsu Geert-Jan Boons Robert P. de Vries
Viruses 13(5) 815-815 2021年5月 [査読有り]
The first step in influenza virus infection is the binding of hemagglutinin to sialic acid-containing glycans present on the cell surface. Over 50 different sialic acid modifications are known, of which N-acetylneuraminic acid (Neu5Ac) and N-glyco...
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