Biochemical and biophysical research communications 536 73-79 2021年1月 [査読有り]
Cerebrospinal fluid (CSF) contains glycosphingolipids, including lactosylceramide (LacCer, Galβ(1,4)Glcβ-ceramide). LacCer and its structural isomer, galabiosylceramide (Gb2, Galα(1,4)Galβ-ceramide), are classified as ceramide dihexosides (CDH). G...
Hirohisa Watanabe Epifanio Bagarinao Satoshi Maesawa Kazuhiro Hara Kazuya Kawabata Aya Ogura Reiko Ohdake Sayuri Shima Yasuaki Mizutani Akihiro Ueda Mizuki Ito Masahisa Katsuno Gen Sobue
Frontiers in aging neuroscience 13 747359-747359 2021年 [査読有り]
To understand the mechanisms underlying preserved and impaired cognitive function in healthy aging and dementia, respectively, the spatial relationships of brain networks and mechanisms of their resilience should be understood. The hub regions of ...
Journal of Parkinson's disease 11(1) 221-232 2021年 [査読有り]
BACKGROUND: As mutations in glucocerebrosidase 1 (GBA1) are a major risk factor for Parkinson's disease (PD), decreased GBA1 activity might play an important role in the pathogenesis of the disease. However, there are currently no reports on gluco...
Yutaka Oji Taku Hatano Shin-Ichi Ueno Manabu Funayama Kei-Ichi Ishikawa Ayami Okuzumi Sachiko Noda Shigeto Sato Wataru Satake Tatsushi Toda Yuanzhe Li Tomoko Hino-Takai Soichiro Kakuta Taiji Tsunemi Hiroyo Yoshino Kenya Nishioka Tatsuya Hattori Yasuaki Mizutani Tatsuro Mutoh Fusako Yokochi Yuta Ichinose Kishin Koh Kazumasa Shindo Yoshihisa Takiyama Tsuyoshi Hamaguchi Masahito Yamada Matthew J Farrer Yasuo Uchiyama Wado Akamatsu Yih-Ru Wu Junko Matsuda Nobutaka Hattori
Brain : a journal of neurology 143(4) 1190-1205 2020年4月 [査読有り]
Recently, the genetic variability in lysosomal storage disorders has been implicated in the pathogenesis of Parkinson's disease. Here, we found that variants in prosaposin (PSAP), a rare causative gene of various types of lysosomal storage disorde...
2021 International Conference of Korean Movement Disorders Society, Best Oral Presentation Award,CSF Lipidomic Alterations Reflects Cognitive Decline and Neuronal Damage in Parkinson’s DiseaseYasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Hirohisa Watanabe
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