研究者氏名	小谷侑
	コダニユウ
URL
所属	藤田医科大学
部署	医学部医学科生理学I
職名	講師
学位	博士（学術）(広島大学)
J-Global ID	201501006426411851

研究キーワード

幹細胞 ,下垂体 ,視床下部 ,神経内分泌学

研究分野

ライフサイエンス / 神経科学一般 /
ライフサイエンス / 生理学 /

経歴

2020年4月

現在

藤田医科大学医学部生理学I 講師

2018年10月

2020年3月

藤田医科大学医学部生理学I 助教

2012年5月

2018年9月

藤田保健衛生大学医学部生理学I 助教

2012年4月

広島大学大学院総合科学研究科研究員

学歴

2007年4月

2012年3月

広島大学大学院総合科学研究科

受賞

2019年10月

日本神経内分泌学会第19回若手研究奨励賞

論文

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Serotonin 5-HT2B receptor antagonism is fundamental for protecting PC12 cells exposed to hydrogen peroxide

Takayanagi T Kaneko YS Nagasaki H Kodani Y Nakashima A Mori K Suzuki A Itoh M Kondo K Nagatsu T Ota M Ota A

Fujita Medical Journal 1(1) 1-5 2015年 [査読有り]

Objectives: According to our previous work, aripiprazole exerted a protective effect on hydrogen peroxide (H2O2)-treated PC12 cells; haloperidol did not. Because aripiprazole has distinct affinities to a set of neurotransmitter receptor subtypes, ...

Induction of Hypothalamic Neurons from Pluripotent Stem Cells

Nagasaki H Kodani Y Suga H

Interdisciplinary Information Sciences 21(3) 261-266 2015年 [査読有り]

Recently, various hypothalamic neurons have been successfully engineered from pluripotent stem cells, including mouse and human embryonic stem cells. Because pluripotent cells need to undergo stepwise changes during organogenesis, developmental an...

Electrostatic charge at position 552 affects the activation and permeation of FMRFamide-gated Na+ channels

Yu Kodani Yasuo Furukawa

JOURNAL OF PHYSIOLOGICAL SCIENCES 64(2) 141-150 2014年3月 [査読有り]

The FMRFamide-gated Na+ channel (FaNaC) is a unique peptide-gated sodium channel and a member of the epithelial sodium channel/degenerin family. Previous studies have shown that an aspartate residue (Asp(552)) in the second transmembrane domain is...

Aripiprazole increases NADPH level in PC12 cells: the role of NADPH oxidase

Hiroshi Nagasaki Akira Nakashima Yoko S. Kaneko Yu Kodani Takeshi Takayanagi Mitsuyasu Itoh Kazunao Kondo Toshiharu Nagatsu Yoji Hamada Miyuki Ota Akira Ota

JOURNAL OF NEURAL TRANSMISSION 121(1) 91-103 2014年1月 [査読有り]

In aripiprazole-treated PC12 cells, we previously showed that the mitochondrial membrane potential (Delta psi(m)) was rather increased in spite of lowered cytochrome c oxidase activity. To address these inconsistent results, we focused the NADPH g...

Intracellular stability of tyrosine hydroxylase. Phosphorylation and proteasomal digestion of the enzyme.

Akira Nakashima Yoko S. Kaneko Yu Kodani Keiji Mori Hiroshi Nagasaki Toshiharu Nagatsu Akira Ota

Advances in Pharmacology 68 3-11 2013年 [査読有り]

Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is a key protein involved in the pathogenesis of neurodegenerative diseases such as Parkinson's disease. Elucidation of the mechanisms regulating the synthe...