BACKGROUND: We aimed to determine the similarities and differences in the roles of genic and regulatory copy number variations (CNVs) in bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD). METHODS: Based on high-resolut...
Journal of psychopharmacology (Oxford, England) 36(9) 2698811221112937-2698811221112937 2022年7月
BACKGROUND: Although clozapine-induced granulocytopenia (CIG) is less severe than clozapine-induced agranulocytosis (CIA), and some patients with CIG may not go on to develop serious complications, clozapine is discontinued in cases of both CIA an...
Rei Aoki Takeo Saito Kohei Ninomiya Ayu Shimasaki Takuma Ashizawa Kenta Ito Masashi Ikeda Nakao Iwata
Psychiatry and clinical neurosciences 76(8) 361-366 2022年5月
AIM: The genetic relationship between schizophrenia (SCZ) and other nonpsychiatric disorders remains largely unknown. We examined the shared genetic components between these disorders based on multipopulation data sets. METHODS: We used two data s...
SETD1A has been identified as a substantial risk gene for schizophrenia. To further investigate the role of SETD1A in the genetic etiology of schizophrenia in the Japanese population, we performed resequencing and association analyses. First, we r...
Kohei Ninomiya Takeo Saito Masashi Ikeda Nakao Iwata François R Girardin
Frontiers in pharmacology 13 1016669-1016669 2022年
The identification of pharmacogenetic factors that increase the susceptibility to clozapine-induced agranulocytosis or granulocytopenia (CIAG) has received increasing interest. The SLCO1B3-SCLO1B7 variant (rs149104283) and single amino acid change...
統合失調症の病態は依然として不明のままであり、現在に至るまでさまざまな切り口から多くの研究がなされてきた。近年、全ゲノム関連研究(genome-wide association study;GWAS)は疾患感受性遺伝子同定に大きく寄与し、病態研究の新たなヒントを与えている。本稿では統合失調症GWASの成果について触れる。(著者抄録)
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