Objective The objective of this study was to estimate the humoral immune response evaluated by immunoglobulin G (IgG) against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD-IgG) following the th...
Nanaka Morita   Masato Hoshi   Hiroyuki Tezuka   Tatsuya Ando   Sayaka Yoshida   Fumiaki Sato   Hiroyuki Yokoi   Hiroyasu Ito   Kuniaki Saito   
ImmunoHorizons 7(5) 353-363 2023年5月
Sepsis is a systemic inflammatory disease caused by a bacterial infection that leads to severe mortality, especially in elderly patients, because of an excessive immune response and impaired regulatory functions. Antibiotic treatment is widely acc...
Tatusya Ando   Daisuke Ito   Kazuya Shiogama   Yasuhiro Sakai   Masato Abe   Takayasu Ideta   Ayumu Kanbe   Masahito Shimizu   Hiroyasu Ito   
Biochemical and Biophysical Research Communications 648 44-49 2023年3月 [査読有り]
A previous study revealed that treatment with the anticoagulant heparin attenuated concanavalin A (ConA)-induced liver injury. The administration of spermidine (SPD) increased urokinase-type plasminogen activator (uPA) levels in the serum. uPA is ...
Hiroyasu Ito   Ayumu Kanbe   Akira Hara   Tetsuya Ishikawa   
Virology 531 233-239 2019年5月
A persistent hepatitis B virus (HBV) infection is characterized by a lack of or a weak immune response to HBV. Efficient induction of the HBV-specific immune response leads to the clearance of HBV. Stimulator of interferon (IFN) genes (STING) is a...