研究者氏名	竹内俊幸

URL
所属	藤田医科大学
部署	医学部医学科分子腫瘍学
職名	助教
学位	博士(生命科学)(鳥取大学)
J-Global ID	201801008046891200

研究キーワード

腫瘍 ,転写因子 ,遺伝子発現

研究分野

ライフサイエンス / 分子生物学 /

経歴

2017年10月

現在

藤田医科大学医学部分子腫瘍学助教

2006年3月

2017年9月

株式会社Oncomics 研究部課長

2001年7月

2006年2月

社団法人バイオ産業情報化コンソシーアム特別研究員

2001年4月

2001年6月

鳥取大学医学部研究生

学歴

1998年4月

2001年3月

鳥取大学大学院医学系研究科博士後期課程

1996年4月

1998年3月

鳥取大学大学院医学系研究科博士前期課程

1992年4月

1996年3月

鳥取大学医学部生命科学科

論文

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LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration

Atsuko Niimi Siripan Limsirichaikul Keiko Kano Yasuyoshi Mizutani Toshiyuki Takeuchi Patinya Sawangsri Dat Quoc Tran Yoshiyuki Kawamoto Motoshi Suzuki

Cancers 15(10) 2781-2781 2023年5月 [査読有り]

CERS6 is associated with metastasis and poor prognosis in non-small cell lung cancer (NSCLC) patients through d18:1/C16:0 ceramide (C16 ceramide)-mediated cell migration, though the detailed mechanism has not been elucidated. In the present study,...

Enzyme-labeled Antigen Method: Factors Influencing the Deterioration of Antigen-binding Activity of Specific Antibodies during Formalin Fixation and Paraffin Embedding.

Yasuyoshi Mizutani Kazuya Shiogama Ken-Ichi Inada Toshiyuki Takeuchi Atsuko Niimi Motoshi Suzuki Yutaka Tsutsumi

Acta histochemica et cytochemica 55(5) 129-148 2022年10月 [査読有り]

The enzyme-labeled antigen method is an immunohistochemical technique detecting plasma cells producing specific antibodies in tissue sections. The probe is an antigen labeled with an enzyme or biotin. This immunohistochemical technique is appliabl...

Alanine-Serine-Cysteine Transporter 2 Inhibition Suppresses Prostate Cancer Cell Growth In Vitro.

Masanobu Saruta Kiyoshi Takahara Atsuhiko Yoshizawa Atsuko Niimi Toshiyuki Takeuchi Takuhisa Nukaya Masashi Takenaka Kenji Zennami Manabu Ichino Hitomi Sasaki Mamoru Kusaka Motoshi Suzuki Makoto Sumitomo Ryoichi Shiroki

Journal of clinical medicine 11(18) 2022年9月 [査読有り]

Alanine-serine-cysteine transporter 2 (ASCT2) has been associated with increased levels of metabolism in various malignant tumors. However, its biological significance in the proliferation of prostate cancer (PCa) cells remains under investigation...

Antitumor effect of polyphyllin D on liver metastases of neuroblastoma.

Yasuhiro Kondo Shunsuke Watanabe Atsuki Naoe Toshiyuki Takeuchi Atsuko Niimi Motoshi Suzuki Naoya Asai Seiji Okada Tomonori Tsuchiya Mika Murayama Toshihiro Yasui Mikihiro Inoue Tatsuya Suzuki

Pediatric surgery international 38(8) 1157-1163 2022年8月 [査読有り]

PURPOSE: We previously reported that polyphyllin D, a main component of the traditional Chinese medicinal herb Paris polyphylla, exhibited anticancer effects in vitro against human neuroblastoma cells. The aims of this investigation was to examine...

CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.

Hanxiao Shi Atsuko Niimi Toshiyuki Takeuchi Kazuya Shiogama Yasuyoshi Mizutani Taisuke Kajino Kenichi Inada Tetsunari Hase Takahiro Hatta Hirofumi Shibata Takayuki Fukui Toyofumi Fengshi Chen-Yoshikawa Kazuki Nagano Takashi Murate Yoshiyuki Kawamoto Shuta Tomida Takashi Takahashi Motoshi Suzuki

Cancer science 112(7) 2770-2780 2021年7月 [査読有り]

Ceramide synthase 6 (CERS6) promotes lung cancer metastasis by stimulating cancer cell migration. To examine the underlying mechanisms, we performed luciferase analysis of the CERS6 promoter region and identified the Y-box as a cis-acting element....