Sumitomo-Kondo M   Ukai Y   Iba Y   Ohshima N   Miura K   Takasaki A   Kurosawa Y   Kurosawa G   
Biochemical and biophysical research communications 503(2) 1141-1147 2018年7月 [査読有り]
MICROBIOLOGY AND IMMUNOLOGY 59(2) 71-81 2015年2月 [査読有り]
Shiga toxin 2 (Stx2)-specific mAb-producing hybridoma clones were generated from mice. Because mice tend to produce small amounts of B subunit (Stx2B)-specific antibodies at the polyclonal antibody level after immunization via the parenteral route...
JOURNAL OF VIROLOGY 88(13) 7130-7144 2014年7月 [査読有り]
Neutralizing antibodies that target the hemagglutinin of influenza virus either inhibit binding of hemagglutinin to cellular receptors or prevent the low-pH-induced conformational change in hemagglutinin required for membrane fusion. In general, t...
Peter S. Lee   Nobuko Ohshima   Robyn L. Stanfield   Wenli Yu   Yoshitaka Iba   Yoshinobu Okuno   Yoshikazu Kurosawa   Ian A. Wilson   
NATURE COMMUNICATIONS 5 3614 2014年4月 [査読有り]
Influenza viruses present a significant health challenge each year, as in the H3N2 epidemic of 2012-2013. Here we describe an antibody, F045-092, that possesses broadly neutralizing activity against the entire H3 subtype and accommodates the natur...
Many people have a history of catching the flu several times during childhood but no additional flu in adulthood, even without vaccination. We analyzed the total repertoire of antibodies (Abs) against influenza A group 1 viruses induced in such a ...