BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 383(4) 480-484 2009年6月 [査読有り]
We reported comprehensive screening for antigens (Ags) overexpressed on various carcinomas via isolation of human monoclonal antibodies (mAbs) that may be therapeutic in a previous paper (Proc. Natl. Acad. Sci. USA 105, 7287-7292, 2008). Twenty-on...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 378(4) 832-835 2009年1月 [査読有り]
We developed a method termed ICOS (isolation of antigen-antibody complexes through organic solvent) for comprehensive isolation of monoclonal antibodies (mAbs) bound to molecules on the cell surface. By mixing a large number of phage particles of ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105(20) 7287-7292 2008年5月 [査読有り]
Although several murine mAbs that have been humanized became useful therapeutic agents against a few malignancies, therapeutic Abs are not yet available for the majority of the human cancers because of our lack of knowledge of which antigens (Ags)...
M Kakita T Takahashi T Komiya Y Iba T Tsuji Y Kurosawa M Takahashi
INFECTION AND IMMUNITY 74(6) 3682-3683 2006年6月 [査読有り]
We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (K-d) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used a...
K Higo-Moriguchi Y Akahori Y Iba Y Kurosawa K Taniguchi
JOURNAL OF VIROLOGY 78(7) 3325-3332 2004年4月 [査読有り]
A human antibody library constructed by utilizing a phage display system was used for the isolation of human antibodies with neutralizing activity specific for human rotavirus. In the library, the Fab form of an antibody fused to truncated cp3 is ...
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