Hyunjeong Yang   Hiroshi Takagi   Yoshiyuki Konishi   Hiroshi Ageta   Koji Ikegami   Ikuko Yao   Showbu Sato   Ken Hatanaka   Kaoru Inokuchi   Dae-Hyun Seog   Mitsutoshi Setou   
PLOS ONE 3(7) e2809 2008年7月 [査読有り]
Some ubiquitin-like (UBL) domain-containing proteins are known to play roles in receptor trafficking. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) undergo constitutive cycling between the intracellular compartment a...
Activin, a member of the transforming growth factor-beta superfamily, is an endocrine hormone that regulates differentiation and proliferation of a wide variety of cells. In the brain, activin protects neurons from ischemic damage. In this study, ...
JOURNAL OF CELL SCIENCE 120(21) 3830-3837 2007年11月 [査読有り]
Long-lasting modifications in synaptic transmission depend on de novo gene expression in neurons. The expression of activin, a member of the transforming growth factor beta (TGF-beta) superfamily, is upregulated during hippocampal long-term potent...
Little is known about how synaptic activity is modulated in the central nervous system. We have identified SCRAPPER, a synapse-localized E3 ubiquitin ligase, which regulates neural transmission. SCRAPPER directly binds and ubiquitinates RIM1, a mo...