Akira Nakashima   Syuhei Ohnuma   Yu Kodani   Yoko S. Kaneko   Hiroshi Nagasaki   Toshiharu Nagatsu   Akira Ota   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 472(4) 598-602 2016年4月 [査読有り]
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. However, the intracellular stability determined by the degradation...
Interdisciplinary Information Sciences 21(3) 261-266 2015年9月
Recently, various hypothalamic neurons have been successfully engineered from pluripotent stem cells, including mouse and human embryonic stem cells. Because pluripotent cells need to undergo stepwise changes during organogenesis, developmental an...
Arginine-vasopressin (AVP) neurons exist in the hypothalamus, a major region of the diencephalon, and play an essential role in water balance. Here, we established the differentiation method for AVP-secreting neurons from human embryonic stem cell...