Hideo Hagihara Hirotaka Shoji Mahomi Kuroiwa Isabella A Graef Gerald R Crabtree Akinori Nishi Tsuyoshi Miyakawa
Molecular brain 15(1) 94-94 2022年11月 [査読有り]
Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intellectual disability, autism spectrum di...
AIM: Capric acid (also known as decanoic acid or C10) is one of the fatty acids in the medium-chain triglycerides (MCTs) commonly found in dietary fats. Although dietary treatment with MCTs is recently of great interest for the potential therapeut...
Lactate has diverse roles in the brain at the molecular and behavioral levels under physiological and pathophysiological conditions. This study investigates whether lysine lactylation (Kla), a lactate-derived post-translational modification in mac...
Kazuo Nakajima Mizuho Ishiwata Adam Z Weitemier Hirotaka Shoji Hiromu Monai Hiroyuki Miyamoto Kazuhiro Yamakawa Tsuyoshi Miyakawa Thomas J McHugh Tadafumi Kato
Human molecular genetics 30(18) 1762-1772 2021年6月 [査読有り]
A report of a family of Darier's disease with mood disorders drew attention when the causative gene was identified as ATP2A2 (or SERCA2), which encodes a Ca2+ pump on the ER membrane and is important for intracellular Ca2+ signaling. Recently, it ...
Maturation and integration of neurons and grial cells in the hippocampus is considered to be essential for regulating endocrine, affective, and congnitive functions, and the disruption of such process may cause mental illness. Previously, we have ...
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