Chromogranin A (CgA), a member of the granin family serves several important cell biological roles in (neuro) endocrine cells which are summarized in this review. CgA is a "prohormone" that is synthesized at the rough endoplasmic reticulum and tra...
JOURNAL OF NEUROSCIENCE RESEARCH 88(1) 64-72 2010年1月 [査読有り]
Carboxypeptidase E (CPE) is involved in maturation of neuropeptides and sorting of brain-derived neurotrophic factor (BDNF) to the regulated pathway for activity-dependent secretion from CNS neurons. CPE knockout (CPE-KO) mice have many neurologic...
JOURNAL OF MOLECULAR NEUROSCIENCE 39(1-2) 1-8 2009年9月 [査読有り]
This review outlines the neuroprotective activities and structural specificities of two distinct proteins, activity-dependent neuroprotective protein, a protein assigned transcription factor/chromatin remodeling activity, and carboxypeptidase E, a...
Joshua J. Park   Hisatsugu Koshimizu   Y. Peng Loh   
JOURNAL OF MOLECULAR NEUROSCIENCE 37(2) 151-159 2009年2月 [査読有り]
Biogenesis and post-Golgi transport of peptidergic secretory granules to the release site are crucial for secretion of neuropeptides from neuroendocrine cells. Recent studies have uncovered multilevel molecular mechanisms for the regulation of sec...
Background: Proneurotrophins and mature neurotrophins elicit opposite effects via the p75 neurotrophin receptor (p75(NTR)) and Trk tyrosine kinase receptors, respectively; however the molecular roles of proneurotrophins in the CNS are not fully un...
① CRH結合蛋白質の可視化(CRH-BP-pHluorin による生細胞中での輸送・放出過程の可視化。昭和大学、香川大学、横浜薬科大との共同研究。詳細はAdachi et al., J. Neurochem. 2018)
*本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター(fuji-san@fujita-hu.ac.jp)まで