Cytogenetic and genome research 146(4) 279-84 2015年 [査読有り]
DEK-NUP214 gene fusion in acute myeloid leukemia (AML) is associated with poor prognosis. It is most often a sole translocation and more rarely observed as complex chromosomal forms. We describe an AML case with complex karyotype abnormalities inv...
Mohammad Alinoor Rahman   Akio Masuda   Kenji Ohe   Mikako Ito   David O Hutchinson   Akila Mayeda   Andrew G Engel   Kinji Ohno   
Scientific reports 3 2931-2931 2013年10月 [査読有り]
CHRNA1 gene, encoding the muscle nicotinic acetylcholine receptor alpha subunit, harbors an inframe exon P3A. Inclusion of exon P3A disables assembly of the acetylcholine receptor subunits. A single nucleotide mutation in exon P3A identified in co...
The mechanisms by which huge human introns are spliced out precisely are poorly understood. We analyzed large intron 7 (110199 nucleotides) generated from the human dystrophin (DMD) pre-mRNA by RT-PCR. We identified branching between the authentic...
Nucleic acids research 40(16) 7896-906 2012年9月 [査読有り]
Transcripts of the human tumor susceptibility gene 101 (TSG101) are aberrantly spliced in many cancers. A major aberrant splicing event on the TSG101 pre-mRNA involves joining of distant alternative 5' and 3' splice sites within exon 2 and exon 9,...
Biochemical and biophysical research communications 423(2) 289-94 2012年6月 [査読有り]
It is unknown how very short introns (<65 nt; termed 'ultra-short' introns) could be spliced in a massive spliceosome (>2.7 MDa) without steric hindrance. By screening an annotated human transcriptome database (H-InvDB), we identified three model ...
① がん由来細胞を用いた、mRNA再スプライシングを含む異常スプライシングの分子機構の解析、
② ヒトの新規スプライシング因子として再発見されたSPF45の、抗がん多剤耐性への関与機構の解析、
*本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進セン
ター(fuji-san@fujita-hu.ac.jp)まで