研究者氏名	西辻裕紀
	ニシツジヒロノリ
通称等の別名	藤田医科大学
URL
所属	藤田医科大学
部署	ウイルス学
職名	准教授
科研費研究者番号	20573661
J-Global ID	201801009029607414

研究分野

ライフサイエンス / ウイルス学 /

論文

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Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins.

Kei Miyakawa Mayuko Nishi Michinaga Ogawa Satoko Matsunaga Masaya Sugiyama Hironori Nishitsuji Hirokazu Kimura Makoto Ohnishi Koichi Watashi Kunitada Shimotohno Takaji Wakita Akihide Ryo

Nature communications 13(1) 531-531 2022年1月

Autophagy has been linked to a wide range of functions, including a degradative process that defends host cells against pathogens. Although the involvement of autophagy in HBV infection has become apparent, it remains unknown whether selective aut...

Establishment of a monoclonal antibody against human NTCP that blocks HBV infection.

Toshitada Takemori Akiko Sugimoto-Ishige Hironori Nishitsuji Yushi Futamura Michishige Harada Tomomi Kimura-Someya Takehisa Matsumoto Teruki Honma Miho Tanaka Masami Yaguchi Kyoichi Isono Haruhiko Koseki Hiroyuki Osada Daiki Miki Takashi Saito Takashi Tanaka Takehiro Fukami Toshio Goto Mikako Shirouzu Kunitada Shimotohno Kazuaki Chayama

Journal of virology JVI0168621 2022年1月

Hepatitis B virus (HBV) infects 240 million people worldwide. Current therapy profoundly suppresses HBV replication but requires long-term maintenance therapy. Therefore there is still a medical need for an efficient HBV cure. HBV enters host cell...

Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure.

Takashi Honda Norie Yamada Asako Murayama Masaaki Shiina Hussein Hassan Aly Asuka Kato Takanori Ito Yoji Ishizu Teiji Kuzuya Masatoshi Ishigami Yoshiki Murakami Tomohisa Tanaka Kohji Moriishi Hironori Nishitsuji Kunitada Shimotohno Tetsuya Ishikawa Mitsuhiro Fujishiro Masamichi Muramatsu Takaji Wakita Takanobu Kato

Cellular and molecular gastroenterology and hepatology 12(5) 1583-1598 2021年8月

BACKGROUND & AIMS: To provide an adequate treatment strategy for chronic hepatitis B, it is essential to know which patients are expected to have a good prognosis and which patients do not require therapeutic intervention. Previously, we identifie...

N-Terminal PreS1 Sequence Regulates Efficient Infection of Cell-Culture-Generated Hepatitis B Virus.

Asako Murayama Norie Yamada Yoshiki Osaki Masaaki Shiina Hussein Hassan Aly Masashi Iwamoto Senko Tsukuda Koichi Watashi Mami Matsuda Ryosuke Suzuki Tomohisa Tanaka Kohji Moriishi Tetsuro Suzuki Hironori Nishitsuji Masaya Sugiyama Masashi Mizokami Kunitada Shimotohno Takaji Wakita Masamichi Muramatsu T Jake Liang Takanobu Kato

Hepatology (Baltimore, Md.) 73(2) 520-532 2021年2月

BACKGROUND AND AIMS: An efficient cell-culture system for hepatitis B virus (HBV) is indispensable for research on viral characteristics and antiviral reagents. Currently, for the HBV infection assay in cell culture, viruses derived from HBV genom...

Identification of Two Critical Neutralizing Epitopes in the Receptor Binding Domain of Hepatitis B Virus preS1.

Keigo Yato Taishi Onodera Mami Matsuda Saya Moriyama Akira Fujimoto Koichi Watashi Hideki Aizaki Tomohisa Tanaka Kohji Moriishi Hironori Nishitsuji Kunitada Shimotohno Koji Tamura Yoshimasa Takahashi Takaji Wakita Masamichi Muramatsu Takanobu Kato Ryosuke Suzuki

Journal of virology 2020年12月

Hepatitis B virus (HBV) infection is a major public health problem. Human hepatocytes are infected with HBV via binding between the preS1 region in the large envelope protein of HBV and sodium taurocholate cotransporting polypeptide. Although seve...