To suppress virus multiplication, infected macrophages produce NO. However, it remains unclear how infecting viruses then overcome NO challenge. In the present study, we report the effects of accessory protein C from Sendai virus (SeV), a prototyp...
The effect of TGF-β1 on CpG DNA-induced type I IFN production was examined by reconstituting a series of signaling molecules in TLR 3 signaling. TGF-β1 inhibited CpG DNA-induced IFN-α4 productivity in HeLa cells. Transfection of IFN regulatory fac...
Here we report that LPS induces osteoclast (OC) formation in murine RAW 264.7 macrophage cells in RPMI-1640 medium but not in α-minimum essential medium (α-MEM) as the original culture medium. LPS-induced OC formation in both media was examined to...
Naoki Koide Erdenezaya Odkhuu Yoshikazu Naiki Bilegtsaikhan Tsolmongyn Kiyoaki Ito Takayuki Komatsu Tomoaki Yoshida Takashi Yokochi
Innate immunity 20(8) 816-25 2014年11月 [査読有り]
The effect of LPS on the production of vascular endothelial growth factor (VEGF) was examined using RAW 264.7 macrophage cells. LPS induced VEGF production in RAW 264.7 cells and mouse peritoneal cells. LPS induced VEGF production via the expressi...
International immunopharmacology 20(1) 181-7 2014年5月 [査読有り]
The inhibitory effect of valproic acid (VPA) on lipopolysaccharide (LPS)-induced inflammatory response was studied by using mouse RAW 264.7 macrophage-like cells. VPA pretreatment attenuated LPS-induced phosphorylation of phosphatidylinositol 3-ki...
Abu Shadat M. Noman Naoki Koide Imtiaz I. E. Khuda Jargalsaikhan Dagvadorj Gantsetseg Tumutkhuu Yoshikazu Naiki Takayuki Komatsu Tomoaki Yoshida Takashi Yokochi
Isamu Mori Fumi Goshima Daisuke Watanabe Hiroyasu Ito Naoki Koide Tomoaki Yoshida Beixing Liu Yoshinobu Kimura Takashi Yokochi Yukihiro Nishiyama
MICROBES AND INFECTION 8(7) 1806-1812 2006年6月
A role for the US3 protein kinase of herpes simplex virus (HSV) in regulating virus-induced neuronal apoptosis was investigated in an experimental mouse system, in which wild-type HSV invades the central nervous system (CNS) via the olfactory and ...
T Yoshida M Fukada N Koide H Ikeda T Sugiyama Y Kato N Ishikawa T Yokochi
JOURNAL OF INFECTIOUS DISEASES 180(6) 2048-2052 1999年12月
Various endothelial cells, with the exception of these from human microvasculatures, have been known to resist Shiga toxins (Stxs) in vitro. However, freshly prepared primary cultures of human endothelial cells from the umbilical vein and artery a...
An experimental model for autoimmune enterocolitis was produced in mice by repeated immunization of homologous colon extract together with Klebsiella O3 lipopolysaccharide (KO3 LPS) as an immunological adjuvant. Histological changes in the ...
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