The regulatory role of tumour necrosis factor-a (TNF-a) on the expression of suppressor of cytokine signalling 3 (SOCS-3) in response to lipopolysaccharide (LPS) was examined using peritoneal macrophages from TNF-a-deficient mice. The LPS-induced ...
The involvement of retinoblastoma protein-interacting zinc finger 1 (RIZ1), a tumor suppressor, in lipopolysaccharide (LPS)-induced inflammatory responses was investigated by using RAW 264.7 macrophage-like cells. LPS significantly augmented the e...
Gantsetseg Tumurkhuu   Naoki Koide   Jargalsaikhan Dagvadorj   Abu S M Noman   Imtiaz I-E Khuda   Yoshikazu Naiki   Takayuki Komatsu   Tomoaki Yoshida   Takashi Yokochi   
Cellular immunology 261(2) 122-7 2010年 [査読有り]
The effect of a series of toll-like receptor (TLR) ligands on the production of nitric oxide (NO) in mouse B1 cells was examined by using CD5(+) IgM(+) WEHI 231 cells. The stimulation with a series of TLR ligands, which were Pam3Csk4 for TLR1/2, p...
International journal of medical microbiology : IJMM 299(8) 554-62 2009年12月 [査読有り]
The effect of Clostridium perfringens alpha-toxin on production of tumor necrosis factor (TNF)-alpha and nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells was studied. The pretreatment of wild type alpha-toxin, but not the i...
Imtiaz I-E Khuda   Naoki Koide   Abu S M Noman   Jargalsaikhan Dagvadorj   Gantsetseg Tumurkhuu   Yoshikazu Naiki   Takayuki Komatsu   Tomoaki Yoshida   Takashi Yokochi   
Immunology 128(1 Suppl) e700-6 2009年9月 [査読有り]
Astrocyte elevated gene-1 (AEG-1) is induced by human immunodeficiency virus 1 (HIV-1) infection and involved in tumour progression, migration and invasion as a nuclear factor-kappaB (NF-kappaB) -dependent gene. The involvement of AEG-1 on lipopol...
The effect of lipopolysaccharide (LPS) on valproic acid (VPA)-induced cell death was examined by using mouse RAW 264.7 macrophage cells. LPS inhibited the activation of caspase 3 and poly (ADP-ribose) polymerase and prevented VPA-induced apoptosis...
Naoki Koide   Yoshikazu Naiki   Erdenezaya Odkhuu   Bilegtsaikhan Tsolmongyn   Takayuki Komatsu   Kiyoaki Ito   Tomoaki Yoshida   Takashi Yokochi   
Oncology research 21(1) 59-65 2013年 [査読有り]
A toll-like receptor 4 (TLR-4) ligand, lipopolysaccharide (LPS) not only activates expression and secretion of inflammatory cytokines, but it also often shows toxicity in monocytes. Whether an oncogenic protein, β-catenin, is positively involved i...
The LPS-mediated lethality of NC/Nga mice, having fewer NKT cells, was examined by using d-galactosamine (d-GalN)-sensitization. The NC/Nga mice were not killed by a simultaneous administration of d-GalN and LPS whereas all C57BL/6 (B6) control mi...
Thalidomide is known as an anti-angiogenic, anti-tumor, and anti-proliferative agent, widely used in the treatment of some immunological disorders and cancers. The effect of thalidomide on interferon (IFN)-gamma induced nitric oxide (NO) productio...