Naoki Yahata Yuji Matsumoto Minoru Omi Naoki Yamamoto Ryuji Hata
SCIENTIFIC REPORTS 7(1) 15557 2017年11月 [査読有り]
Induced pluripotent stem cells (iPSCs) are suitable for studying mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations. Here, we generated iPSCs from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke...
JOURNAL OF ALZHEIMERS DISEASE 51(4) 997-1002 2016年 [査読有り]
As a proof of concept that removal of blood amyloid-beta (A beta) can reduce A beta deposition in the brains of patients with Alzheimer's disease, cortices of patients who had undergone hemodialysis (HD), which removes A beta from the blood, were ...
Masahiro Sakanaka Pengxiang Zhu Bo Zhang Tong-Chun Wen Fang Cao Yong-Jie Ma Keiichi Samukawa Noriaki Mitsuda Junya Tanaka Makoto Kuramoto Hidemitsu Uno Ryuji Hatai
JOURNAL OF NEUROTRAUMA 24(6) 1037-1054 2007年6月 [査読有り]
Red ginseng root (Panax Ginseng CA Meyer) has been used clinically by many Asian people for thousands of years without any detrimental effects. One of the major components of Red ginseng root is ginsenoside Rb-1 (gRb1). Previously, we showed that ...
The effects of transient cochlear ischemia on spiral ganglion cells (SGCs) were studied in Mongolian gerbils. Ischemic insult was induced by occluding the bilateral vertebral arteries of gerbils for 15 min. Seven days after ischemia, the percentag...
Fang Cao Ryuji Hata Pengxiang Zhu Koh-ichi Nakashiro Masahiro Sakanaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394(3) 843-847 2010年4月 [査読有り]
Although signal transducer and activator of transcription 3 (Stat3) plays crucial roles in the determination of neural stem cell (NSC) fate, Stat3 has multiple roles in NSC function Moreover, Stat3 plays important roles in neuronal survival and tu...
Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single isc...
Fang Cao Ryuji Hata Pengxiang Zhu Michinobu Niinobe Masahiro Sakanaka
BRAIN RESEARCH 1272 52-61 2009年5月 [査読有り]
Syntaxin1 and synaptotagmin are located in the pre-synaptic terminals and play central roles in Ca(2+)-triggered neurotransmitter release. Because excessive synaptic transmission has been implicated in neuronal cell death after ischemia, we invest...
Pengxiang Zhu Ryuji Hata Fang Cao Feng Gu Yasushi Hanakawa Koji Hashimoto Masahiro Sakanaka
FASEB JOURNAL 22(11) 3866-3877 2008年11月 [査読有り]
The differentiation and proliferation of neural stem cells (NSCs) are regulated by a combination of their intrinsic properties (e.g., transcription factors, epigenetic factors, and microRNA regulation) and cell-extrinsic properties from the microe...
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