F Cao R Hata P Zhu YJ Ma J Tanaka Y Hanakawa K Hashimoto M Niinobe K Yoshikawa M Sakanaka
JOURNAL OF NEUROCHEMISTRY 98(2) 459-470 2006年7月 [査読有り]
To investigate the effects of suppressors of cytokine signaling 3 (SOCS3) on neural stem cell fate, stem cells were infected with an adenoviral vector expressing SOCS3. Three days later, western blot analysis and immunocytochemical analysis reveal...
B Zhang R Hata PX Zhu K Sato TC Wen LH Yang H Fujita N Mitsuda J Tanaka K Samukawa N Maeda M Sakanaka
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 26(5) 708-721 2006年5月 [査読有り]
Almost all agents that exhibit neuroprotection when administered into the cerebral ventricles are ineffective or much less effective in rescuing damaged neurons when infused into the blood stream. Search for an intravenously infusible drug with a ...
N Hakuba R Hata Morizane, I G Feng Y Shimizu K Fujita T Yoshida M Sakanaka K Gyo
NEUROREPORT 16(14) 1545-1549 2005年9月 [査読有り]
Neural stem cells are multipotent progenitor cells that show self-renewal activity. In this study, we assessed the use of neural stem cells for ameliorating ischemia-reperfusion injury of the gerbil cochlea. Neural stem cells were injected into on...
F Gu R Hata YJ Ma J Tanaka N Mitsuda Y Kumon Y Hanakawa K Hashimoto K Nakajima M Sakanaka
JOURNAL OF NEUROSCIENCE RESEARCH 81(2) 163-171 2005年7月 [査読有り]
To investigate the effects of signal transducer and activator of transcription 3 (Stat3) on neural stem cell fate, stem cells were inoculated with an adenovirus vector expressing dominant negative form of Stat3 (Stat3F). One day later, a promoter ...
K Taguchi HD Yamagata WT Zhong K Kamino H Akatsu R Hata T Yamamoto K Kosaka M Takeda Kondo, I T Miki
ANNALS OF NEUROLOGY 57(4) 585-588 2005年4月 [査読有り]
Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphi...
Taro Takagi Tadashi Yoshida Masahiro Okada Ryuji Hata Naohito Hato Kiyofumi Gyo Nobuhiro Hakuba
NEUROREPORT 25(11) 807-813 2014年8月 [査読有り]
Bone marrow mononuclear cells (BMMCs) are known to enhance recovery from ischemic insults by secreting angiogenic factors and inducing the expression of angiogenic factors from host tissues. Therefore, the transplantation of BMMCs is considered a ...
Oligomeric forms of amyloid-beta peptide (A beta) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we generated induced pluripotent stem cells (iPSCs) from famil...
Pengxiang Zhu Ryuji Hata Masahito Ogasawara Fang Cao Kenji Kameda Kohei Yamauchi Alfred H. Schinkel Kazutaka Maeyama Masahiro Sakanaka
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 32(10) 1897-1908 2012年10月 [査読有り]
The organic cation transporters OCT1, 2, and 3 (SLC22A1-3) have been implicated in the elimination of biogenic amines such as histamine. Among them, OCT3 was identified as an uptake-2 transporter, responsible for clearance of histamine. Because in...
Naomi Sonobe Ryuji Hata Tomohisa Ishikawa Kantaro Sonobe Teruhisa Matsumoto Yasutaka Toyota Takaaki Mori Ryuji Fukuhara Kenjiro Komori Shu-ichi Ueno Satoshi Tanimukai Manabu Ikeda
INTERNATIONAL PSYCHOGERIATRICS 23(5) 772-779 2011年6月 [査読有り]
Background: Memory impairment has been proposed as the most common early sign of Alzheimer's disease (AD). The aims of this work were to evaluate the risk of progression from mild memory impairment / no dementia (MMI/ND) to clinically diagnos...
Akihiko Taguchi Pengxiang Zhu Fang Cao Akie Kikuchi-Taura Yukiko Kasahara David M. Stern Toshihiro Soma Tomohiro Matsuyama Ryuji Hata
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 31(3) 855-867 2011年3月 [査読有り]
Circulating bone marrow-derived immature cells, including endothelial progenitor cells, have been implicated in homeostasis of the microvasculature. Decreased levels of circulating endothelial progenitor cells, associated with aging and/or cardiov...
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