研究者氏名	浅井直也
	アサイナオヤ
所属	藤田医科大学
部署	医学部病理学講座
職名	教授
学位	博士（医学）(名古屋大学)
J-Global ID	200901070978348285

研究キーワード

遺伝子改変マウスの作製と解析

研究分野

ライフサイエンス / 実験病理学 /

経歴

2019年4月

現在

藤田医科大学医学部病理学講座教授

2009年4月

2019年3月

名古屋大学大学院医学系研究科附属神経疾患・腫瘍分子医学研究センター先端応用医学部門准教授

論文

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Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.

Ryota Ando Yukihiro Shiraki Yuki Miyai Hiroki Shimizu Kazuhiro Furuhashi Shun Minatoguchi Katsuhiro Kato Akira Kato Tadashi Iida Yasuyuki Mizutani Kisuke Ito Naoya Asai Shinji Mii Nobutoshi Esaki Masahide Takahashi Atsushi Enomoto

The Journal of pathology 2023年10月

Pancreatic stellate cells (PSCs) are stromal cells in the pancreas that play an important role in pancreatic pathology. In chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), PSCs are known to get activated to form myofibroblast...

脂肪細胞分泌因子アディプシンの喪失による乳がんの浸潤・転移の抑制(Lack of adipokine adipsin suppresses breast cancer invasion and metastasis)

林孝典吉田淳平宗綱栄二 Behnoush Khaledian 前田真男水野真広牛田かおり河田健司浅井直也下野洋平

日本癌学会総会記事 82回 978-978 2023年9月

アディプシン依存的な脂肪細胞分化は脂肪細胞と乳がん幹細胞の相互作用を増進する(Adipsin-dependent adipocyte differentiation promotes the adipocyte-breast cancer stem cell interactions)

Khaledian Behnoush 吉田淳平林孝典水野真広牛田かおり前田真男宗綱栄二河田健司浅井直也下野洋平 Shimono Yohei

日本癌学会総会記事 82回 1349-1349 2023年9月

Effect of eribulin on epithelial-mesenchymal transition plasticity in metastatic breast cancer: An exploratory, prospective study.

Takanori Hayashi Naomi Kobayashi Kaori Ushida Naoya Asai Shogo Nakano Kimihito Fujii Takahito Ando Toshiaki Utsumi

Genes to cells : devoted to molecular & cellular mechanisms 2023年2月 [査読有り]

Epithelial-mesenchymal transition (EMT) plays a pivotal role in cancer metastasis and treatment resistance, which worsens prognosis. In phase III trials, eribulin improved overall survival in metastatic breast cancer (MBC) patients. In preclinical...

A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts

Shun Minatoguchi Shoji Saito Kazuhiro Furuhashi Yuriko Sawa Masaki Okazaki Yuko Shimamura Ahmad Baseer Kaihan Yusaku Hashimoto Yoshinari Yasuda Akitoshi Hara Yasuyuki Mizutani Ryota Ando Noritoshi Kato Takuji Ishimoto Naotake Tsuboi Nobutoshi Esaki Makoto Matsuyama Yukihiro Shiraki Hiroki Kobayashi Naoya Asai Atsushi Enomoto Shoichi Maruyama

Scientific Reports 12(1) 2022年12月

Abstract

Perivascular mesenchymal cells (PMCs), which include pericytes, give rise to myofibroblasts that contribute to chronic kidney disease progression. Several PMC markers have been identified; however, PMC heterogeneity and functions are not...

MISC

<123 4 5 >

Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells.

Yi-Peng Han Atsushi Enomoto Yukihiro Shiraki Shen-Qi Wang Xiaoze Wang Shinya Toyokuni Naoya Asai Kaori Ushida Hosne Ara Fumiharu Ohka Toshihiko Wakabayashi Jie Ma Atsushi Natsume Masahide Takahashi

Neuro-oncology 19(5) 636-647 2017年5月 [査読有り]

Background: The significance of mammalian target of rapamycin complex 1 (mTORC1) activity in the maintenance of cancer stem cells (CSCs) remains controversial. Previous findings showed that mTORC1 activation depleted the population of leukemia ste...

Topics from special edition 脂肪組織の凍結標本作製 : 乳癌迅速病理診断への応用を目指して

牛田かおり浅井直也髙橋雅英

細胞 48(7) 343-346 2016年7月

CCDC88A mutations cause PEHO-like syndrome in humans and mouse.

Michael S Nahorski Masato Asai Emma Wakeling Alasdair Parker Naoya Asai Natalie Canham Susan E Holder Ya-Chun Chen Joshua Dyer Angela F Brady Masahide Takahashi C Geoffrey Woods

Brain : a journal of neurology 139(Pt 4) 1036-44 2016年4月 [査読有り]

Progressive encephalopathy with oedema, hypsarrhythmia and optic atrophy (PEHO) syndrome is a rare Mendelian phenotype comprising severe retardation, early onset epileptic seizures, optic nerve/cerebellar atrophy, pedal oedema, and early death. At...

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells.

Keiko Maeda Atsushi Enomoto Akitoshi Hara Naoya Asai Takeshi Kobayashi Asuka Horinouchi Shoichi Maruyama Yuichi Ishikawa Takahiro Nishiyama Hitoshi Kiyoi Takuya Kato Kenju Ando Liang Weng Shinji Mii Masato Asai Yasuyuki Mizutani Osamu Watanabe Yoshiki Hirooka Hidemi Goto Masahide Takahashi

Scientific reports 6 22288-22288 2016年2月 [査読有り]

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) in culture are derived from BM stromal cells or skeletal stem cells. Whereas MSCs have been exploited in clinical medicine, the identification of MSC-specific markers has been limited. Here, ...

Meflin is a specific marker for mesenchymal stem cells (MSCs) whose expression is regulated by substrate stiffness.

A. Enomoto N. Asai T. Kobayashi N. Nakamura M. Takahashi

MOLECULAR BIOLOGY OF THE CELL 27 2016年