研究者氏名	浅井直也
	アサイナオヤ
所属	藤田医科大学
部署	医学部病理学講座
職名	教授
学位	博士（医学）(名古屋大学)
J-Global ID	200901070978348285

研究キーワード

遺伝子改変マウスの作製と解析

研究分野

ライフサイエンス / 実験病理学 /

経歴

2019年4月

現在

藤田医科大学医学部病理学講座教授

2009年4月

2019年3月

名古屋大学大学院医学系研究科附属神経疾患・腫瘍分子医学研究センター先端応用医学部門准教授

論文

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脂肪細胞からのアディプシン依存性HGF分泌は乳がんのがん幹細胞性を促進する

水野真広ベフヌーシュ・ハレディアン前田真男田草川栞里矢野愛佳浅井直也下野洋平

日本癌学会総会記事 80回 [P13-6] 2021年9月

脂肪細胞はMCP1を介して卵巣がんのがん幹細胞性を促進する

矢野愛佳前田真男西尾永司田草川栞里林孝典鈴木元浅井直也藤井多久磨佐谷秀行下野洋平

日本癌学会総会記事 80回 [P14-3] 2021年9月

脂肪細胞はDPP4を分泌して卵巣がんのがん幹細胞性を促進する

田草川栞里前田真男矢野愛佳西尾永司林孝典岡田誠治鈴木元浅井直也藤井多久磨佐谷秀行下野洋平

日本癌学会総会記事 80回 [P14-4] 2021年9月

Adipsin-Dependent Secretion of Hepatocyte Growth Factor Regulates the Adipocyte-Cancer Stem Cell Interaction.

Masahiro Mizuno Behnoush Khaledian Masao Maeda Takanori Hayashi Seiya Mizuno Eiji Munetsuna Takashi Watanabe Seishi Kono Seiji Okada Motoshi Suzuki Shintaro Takao Hironobu Minami Naoya Asai Fumihiro Sugiyama Satoru Takahashi Yohei Shimono

Cancers 13(16) 2021年8月

Adipose tissue is a component of the tumor microenvironment and is involved in tumor progression. We have previously shown that adipokine adipsin (CFD) functions as an enhancer of tumor proliferation and cancer stem cell (CSC) properties in breast...

Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity.

Akitoshi Hara Katsuhiro Kato Toshikazu Ishihara Hiroki Kobayashi Naoya Asai Shinji Mii Yukihiro Shiraki Yuki Miyai Ryota Ando Yasuyuki Mizutani Tadashi Iida Mikito Takefuji Toyoaki Murohara Masahide Takahashi Atsushi Enomoto

Genes to cells : devoted to molecular & cellular mechanisms 26(7) 495-512 2021年7月

Mesenchymal stem cells (MSCs) are the likely precursors of multiple lines of mesenchymal cells. The existence of bona fide MSCs with self-renewal capacity and differentiation potential into all mesenchymal lineages, however, has been unclear becau...

MISC

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Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note.

Kaori Ushida Naoya Asai Kozo Uchiyama Atsushi Enomoto Masahide Takahashi

Pathology international 68(4) 241-245 2018年4月 [査読有り]

Embedding of tissue samples that maintains a desired orientation is critical for preparing sections suitable for diagnosis and study objectives. Methods to prepare tissue sections include: (i) paraffin embedding or snap-freezing followed by microt...

The role of CD109 in PDGFB-induced glioma mouse model for sensitivity to Temozolomide

Shiraki Yukihiro Mii Shinji Asai Naoya Enomoto Atsushi Momota Hiroyuki Natsume Atsushi Wakabayashi Toshihiko Takahashi Masahide

CANCER SCIENCE 109 1130-1130-1130 2018年1月

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma.

Yukihiro Shiraki Shinji Mii Atsushi Enomoto Hiroyuki Momota Yi-Peng Han Takuya Kato Kaori Ushida Akira Kato Naoya Asai Yoshiki Murakumo Kosuke Aoki Hiromichi Suzuki Fumiharu Ohka Toshihiko Wakabayashi Tomoki Todo Seishi Ogawa Atsushi Natsume Masahide Takahashi

The Journal of pathology 243(4) 468-480 2017年12月 [査読有り]

In the progression of glioma, tumour cells often exploit the perivascular microenvironment to promote their survival and resistance to conventional therapies. Some of these cells are considered to be brain tumour stem cells (BTSCs); however, the m...

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus.

Maki Takagishi Masato Sawada Shinya Ohata Naoya Asai Atsushi Enomoto Kunihiko Takahashi Liang Weng Kaori Ushida Hosne Ara Shigeyuki Matsui Kozo Kaibuchi Kazunobu Sawamoto Masahide Takahashi

Cell reports 20(4) 960-972 2017年7月 [査読有り]

Motile cilia in ependymal cells, which line the cerebral ventricles, exhibit a coordinated beating motion that drives directional cerebrospinal fluid (CSF) flow and guides neuroblast migration. At the apical cortex of these multi-ciliated cells, a...

Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut.

Daisuke Kuga Kaori Ushida Shinji Mii Atsushi Enomoto Naoya Asai Masato Nagino Masahide Takahashi Masato Asai

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 65(6) 347-366 2017年6月 [査読有り]

Tuft cells (TCs) are minor components of gastrointestinal epithelia, characterized by apical tufts and spool-shaped somas. The lack of reliable TC-markers has hindered the elucidation of its role. We developed site-specific and phosphorylation-sta...