Tetsuya Takano Mengya Wu Shinichi Nakamuta Honda Naoki Naruki Ishizawa Takashi Namba Takashi Watanabe Chundi Xu Tomonari Hamaguchi Yoshimitsu Yura Mutsuki Amano Klaus M. Hahn Kozo Kaibuchi
NATURE COMMUNICATIONS 8(1) 33 2017年6月 [査読有り]
A long-standing question in neurodevelopment is how neurons develop a single axon and multiple dendrites from common immature neurites. Long-range inhibitory signaling from the growing axon is hypothesized to prevent outgrowth of other immature ne...
An improved unroofing method consisting of tearing off the cell membrane using an adhesive electron microscopy (EM) grid instead of vitreous ice sectioning (cryo-sectioning) has enabled us to panoramically view the membrane cytoskeleton in its nat...
Arginine vasopressin (AVP) is secreted via exocytosis; however, the precise molecular mechanism underlying the exocytosis of AVP remains to be elucidated. To better understand the mechanisms of AVP secretion, in our study we have identified protei...
Kenji Matsuzawa Hiroki Akita Takashi Watanabe Mai Kakeno Toshinori Matsui Shujie Wang Kozo Kaibuchi
MOLECULAR BIOLOGY OF THE CELL 27(9) 1511-1523 2016年5月 [査読有り]
Tiam1 is one of the most extensively analyzed activators of the small GTPase Rac. However, fundamental aspects of its regulation are poorly understood. Here we demonstrate that Tiam1 is functionally suppressed by internal interactions and that the...
JOURNAL OF NEUROSCIENCE 35(43) 14517-14532 2015年10月 [査読有り]
How extracellular cues direct axon-dendrite polarization in mouse developing neurons is not fully understood. Here, we report that the radial glial cell (RGC)-cortical neuron interaction directs axon formation at the opposite side of the neuron fr...
お知らせ・マニュアル
医学部