Mari Nakamura Seiji Shiozawa Daisuke Tsuboi Mutsuki Amano Hirotaka Watanabe Sumihiro Maeda Taeko Kimura Sho Yoshimatsu Fumihiko Kisa Celeste M Karch Tomohiro Miyasaka Akihiko Takashima Naruhiko Sahara Shin-Ichi Hisanaga Takeshi Ikeuchi Kozo Kaibuchi Hideyuki Okano

Stem cell reports 13(4) 684-699 2019年10月 [査読有り]

Mutations in the microtubule-associated protein tau (MAPT) gene are known to cause familial frontotemporal dementia (FTD). The R406W tau mutation is a unique missense mutation whose patients have been reported to exhibit Alzheimer's disease (AD)-l...

Comprehensive analysis of kinase-oriented phospho-signalling pathways.

Mutsuki Amano Tomoki Nishioka Daisuke Tsuboi Keisuke Kuroda Yasuhiro Funahashi Yukie Yamahashi Kozo Kaibuchi

Journal of biochemistry 165(4) 301-307 2019年4月 [査読有り]

Accumulating information on eukaryotic protein phosphorylation implies a large and complicated phospho-signalling network in various cellular processes. Although a large number of protein phosphorylation sites have been detected, their physiologic...

In Vivo Identification of Protein Kinase Substrates by Kinase-Oriented Substrate Screening (KIOSS).

Tomoki Nishioka Mutsuki Amano Yasuhiro Funahashi Daisuke Tsuboi Yukie Yamahashi Kozo Kaibuchi

Current protocols in chemical biology 11(1) e60 2019年3月 [査読有り]

Protein phosphorylation plays a critical role in the regulation of cellular function. Information on protein phosphorylation and the responsible kinases is important for understanding intracellular signaling. A method for in vivo screening of kina...

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo

Taku Nagai Shinichi Nakamuta Keisuke Kuroda Sakura Nakauchi Tomoki Nishioka Tetsuya Takano Xinjian Zhang Daisuke Tsuboi Yasuhiro Funahashi Takashi Nakano Junichiro Yoshimoto Kenta Kobayashi Motokazu Uchigashima Masahiko Watanabe Masami Miura Akinori Nishi Kazuto Kobayashi Kiyofumi Yamada Mutsuki Amano Kozo Kaibuchi

NEURON 89(3) 550-565 2016年2月 [査読有り]

Dopamine (DA) type 1 receptor (D1R) signaling in the striatum presumably regulates neuronal excitability and reward-related behaviors through PKA. However, whether and how D1Rs and PKA regulate neuronal excitability and behavior remain largely unk...

Single-Cell Memory Regulates a Neural Circuit for Sensory Behavior

Kyogo Kobayashi Shunji Nakano Mutsuki Amano Daisuke Tsuboi Tomoki Nishioka Shingo Ikeda Genta Yokoyama Kozo Kaibuchi Ikue Mori

CELL REPORTS 14(1) 11-21 2016年1月 [査読有り]

Unveiling the molecular and cellular mechanisms underlying memory has been a challenge for the past few decades. Although synaptic plasticity is proven to be essential for memory formation, the significance of "single-cell memory'' still remains e...

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Mechanism of dopamine signaling for membrane excitability

D. Tsuboi T. Shimomura T. Nakano T. Nagai M. Amano J. Yoshimoto Y. Kubo K. Kaibuchi

JOURNAL OF NEUROCHEMISTRY 142 135-135 2017年8月

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.

Neuron 89(3) 550-65 2016年2月 [査読有り]

注目の遺伝子(第31回)統合失調症発症脆弱性分子DISC1の研究から明らかになった課題と新機能

坪井大輔森大輔黒田啓介

分子精神医学 15(4) 301-303 2015年10月

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

Daisuke Ibi Taku Nagai Akira Nakajima Hiroyuki Mizoguchi Takahiro Kawase Daisuke Tsuboi Shin-Ichi Kano Yoshiaki Sato Masahiro Hayakawa Ulrike C. Lange David J. Adams M. Azim Surani Takaya Satoh Akira Sawa Kozo Kaibuchi Toshitaka Nabeshima Kiyofumi Yamada

GLIA 61(5) 679-693 2013年5月

Interferon-induced transmembrane protein 3 (IFITM3) plays a crucial role in the antiviral responses of Type I interferons (IFNs). The role of IFITM3 in the central nervous system (CNS) is, however, largely unknown, despite the fact that its expres...

精神疾患を分子生物学で考えてみる : 統合失調症発症脆弱性因子DISC1をモデルとして

貝淵弘三坪井大輔

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 30(3) 149-152 2010年6月