Hiroki Kimura Daisuke Tsuboi Chenyao Wang Itaru Kushima Takayoshi Koide Masashi Ikeda Yoshimi Iwayama Tomoko Toyota Noriko Yamamoto Shohko Kunimoto Yukako Nakamura Akira Yoshimi Masahiro Banno Jingrui Xing Yuto Takasaki Mami Yoshida Branko Aleksic Yota Uno Takashi Okada Tetsuya Iidaka Toshiya Inada Michio Suzuki Hiroshi Ujike Hiroshi Kunugi Tadafumi Kato Takeo Yoshikawa Nakao Iwata Kozo Kaibuchi Norio Ozaki

Schizophrenia Bulletin 41(3) 744-753 2015年5月

© The Author 2015. Background: Nuclear distribution E homolog 1 (NDE1), located within chromosome 16p13.11, plays an essential role in microtubule organization, mitosis, and neuronal migration and has been suggested by several studies of rare copy...

Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity

Daisuke Tsuboi Keisuke Kuroda Motoki Tanaka Takashi Namba Yukihiko Iizuka Shinichiro Taya Tomoyasu Shinoda Takao Hikita Shinsuke Muraoka Michiro Iizuka Ai Nimura Akira Mizoguchi Nobuyuki Shiina Masahiro Sokabe Hideyuki Okano Katsuhiko Mikoshiba Kozo Kaibuchi

NATURE NEUROSCIENCE 18(5) 698-+ 2015年5月 [査読有り]

Disrupted-in-schizophrenia 1 (DISC1) is a susceptibility gene for major psychiatric disorders, including schizophrenia. DISC1 has been implicated in neurodevelopment in relation to scaffolding signal complexes. Here we used proteomic analysis to s...

プロテオミクスから見た統合失調症の病態生理

坪井大輔天野睦紀西岡朋生貝淵弘三

日本プロテオーム学会大会要旨集 2012 63-63 2012年

Disrupted-In-Schizoprenia-1 regulates transport of neuronal mRNA

Tsuboi D Kuroda K Iizuka Y Okano H Mikoshiba K Kaibuchi K

Society for Neuroscience Abstract Viewer and Itinerary Planner 42 2012年 [査読有り]

MISC

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Mechanism of dopamine signaling for membrane excitability

D. Tsuboi T. Shimomura T. Nakano T. Nagai M. Amano J. Yoshimoto Y. Kubo K. Kaibuchi

JOURNAL OF NEUROCHEMISTRY 142 135-135 2017年8月

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.

Taku Nagai Shinichi Nakamuta Keisuke Kuroda Sakura Nakauchi Tomoki Nishioka Tetsuya Takano Xinjian Zhang Daisuke Tsuboi Yasuhiro Funahashi Takashi Nakano Junichiro Yoshimoto Kenta Kobayashi Motokazu Uchigashima Masahiko Watanabe Masami Miura Akinori Nishi Kazuto Kobayashi Kiyofumi Yamada Mutsuki Amano Kozo Kaibuchi

Neuron 89(3) 550-65 2016年2月 [査読有り]

Dopamine (DA) type 1 receptor (D1R) signaling in the striatum presumably regulates neuronal excitability and reward-related behaviors through PKA. However, whether and how D1Rs and PKA regulate neuronal excitability and behavior remain largely unk...

注目の遺伝子(第31回)統合失調症発症脆弱性分子DISC1の研究から明らかになった課題と新機能

坪井大輔森大輔黒田啓介

分子精神医学 15(4) 301-303 2015年10月

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

Daisuke Ibi Taku Nagai Akira Nakajima Hiroyuki Mizoguchi Takahiro Kawase Daisuke Tsuboi Shin-Ichi Kano Yoshiaki Sato Masahiro Hayakawa Ulrike C. Lange David J. Adams M. Azim Surani Takaya Satoh Akira Sawa Kozo Kaibuchi Toshitaka Nabeshima Kiyofumi Yamada

GLIA 61(5) 679-693 2013年5月

Interferon-induced transmembrane protein 3 (IFITM3) plays a crucial role in the antiviral responses of Type I interferons (IFNs). The role of IFITM3 in the central nervous system (CNS) is, however, largely unknown, despite the fact that its expres...

精神疾患を分子生物学で考えてみる : 統合失調症発症脆弱性因子DISC1をモデルとして

貝淵弘三坪井大輔

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 30(3) 149-152 2010年6月