日本神経精神薬理学会, JSNP Excellent Presentation Award for AsCNP,The ubiquitination of serotonin transporter in lymphoblasts derived from fluvoxamine-resistant depression patients
Indoleamine 2,3-dioxygenase 2 (IDO2) is an enzyme of the tryptophan-kynurenine pathway that is constitutively expressed in the brain. To provide insight into the physiological role of IDO2 in the brain, behavioral and neurochemical analyses in IDO...
Chronic orofacial pain (COP) is relieved by duloxetine (DLX) and frequently causes depressive symptoms. The aim of this study was to confirm effects of DLX on pain and depressive symptoms, and to associate with their effectiveness in pl...
British journal of pharmacology 180(18) 2393-2411 2023年4月
BACKGROUND AND PURPOSE: High salt (HS) intake has been associated with hypertension and cognitive impairment. It is well-known that angiotensin II (Ang II)-AT1 and prostaglandin E2 (PGE2)-EP1 systems are involved in hypertension and neurotoxicity....
Introduction: Burning mouth syndrome and atypical odontalgia (BMS/AO) are chronic orofacial pain conditions in the absence of any identifiable odontogenic pathology. The pain is treatment-resistant and frequently causes depressive symptoms....
Exposure to psychosocial stress (e.g., bullying) in juveniles is a risk factor of stress-related psychiatric disorders later in life. The exposure to stress activates microglia, which plays an important role in brain immunity, and induces neuroinf...
Maternal use of valproic acid (VPA) during pregnancy is associated with an increased risk of autism spectrum disorder (ASD) in the offspring. In the pathophysiological hypothesis of ASD, excitation/inhibition (E/I) imbalance is attracted. Dysfunct...