Calcitonin receptor (Calcr) is expressed in adult muscle stem cells (muscle satellite cells [MuSCs]). To elucidate the role of Calcr, we conditionally depleted Calcr from adult MuSCs and found that impaired regeneration after muscle injury correla...
When skeletal muscle fibers are injured, they regenerate and grow until their sizes are adjusted to surrounding muscle fibers and other relevant organs. In this study, we examined whether Mest, one of paternally expressed imprinted genes that regu...
Daigo Nishimura   Hiroshi Sakai   Takahiko Sato   Fuminori Sato   Satoshi Nishimura   Noriko Toyama-Sorimachi   Joerg W. Bartsch   Atsuko Sehara-Fujisawa   
MECHANISMS OF DEVELOPMENT 135 58-67 2015年2月 [査読有り]
Skeletal muscle regeneration requires processes different from developmental myogenesis. One important difference is a requirement of inflammatory reactions prior to regenerative myogenesis, by which injured muscle fibers must be eliminated to mak...
Neural crest cells (NCCs) are an embryonic migratory cell population with the ability to differentiate into a wide variety of cell types that contribute to the craniofacial skeleton, cornea, peripheral nervous system, and skin pigmentation. This a...
Takahiko Sato   Takuya Yamamoto   Atsuko Sehara-Fujisawa   
NATURE COMMUNICATIONS 5 4597 2014年8月 [査読有り]
Skeletal muscle stem cells (MuSCs), the major source for skeletal muscle regeneration in vertebrates, are in a state of cell cycle arrest in adult skeletal muscles. Prior evidence suggests that embryonic muscle progenitors proliferate and differen...